Abstract
Movement disorders are a major cause of disability worldwide and their increasing prevalence predicts a substantial future burden of care. Impactful patient care requires availability of, and accessibility to, effective medications, knowledge, and disease awareness among both medical professionals and patients, driven by skilled personnel to harness and manage resources. The highest burden of movement disorders is in low-to-middle income countries where resources are often limited and infrastructure is insufficient to meet growing demands. This article focuses on the specific challenges faced in the management and delivery of care for movement disorders in Indochina, the mainland region of Southeast Asia comprising the neighboring countries of Cambodia, Laos, Malaysia, Myanmar, Thailand, and Vietnam. The first Indochina Movement Disorders Conference was held in August 2022 in Ho Chi Minh City, Vietnam, to provide a platform to better understand the situation in the region. Future management of movement disorders in Indochina will require progressive adaptation of existing practices to reflect modern approaches to care delivery. Digital technologies offer an opportunity to strengthen these processes and address the challenges identified in the region. Ultimately, a long-term collaborative approach by regional healthcare providers is key.
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References
Aggarwal A, Adukia S, Bhatt M (2021) Video anthology of movement disorders due to infections in south Asia. Mov Disord Clin Pract 8(6):843–858. https://doi.org/10.1002/mdc3.13275
Atlas: Country Resources for Neurological Disorders (2017) World Health Organization, Geneva
Azmin S, Sahathevan R, Suehazlyn Z, Law ZK, Rabani R, Nafisah WY, Tan HJ, Norlinah MI (2013) Post-dengue parkinsonism. BMC Infect Dis 13:179. https://doi.org/10.1186/1471-2334-13-179
Bhidayasiri R, Brenden N, Viwattanakulvanid P, Jitkritsadakul O, Tabucanon R, Jagota P, Hojer H (2014) Identifying gaps in knowledge about Parkinson disease among medical professionals in Thailand. Neurology 82(24):2238–2240. https://doi.org/10.1212/WNL.0000000000000515
Bhidayasiri R, Hattori N, Jeon B, Chen RS, Lee MK, Bajwa JA, Mok VC, Zhang B, Syamsudin T, Tan LC, Jamora RD, Pisarnpong A, Poewe W (2015) Asian perspectives on the recognition and management of levodopa “wearing-off” in Parkinson’s disease. Expert Rev Neurother 15(11):1285–1297. https://doi.org/10.1586/14737175.2015.1088783
Bhidayasiri R, Kaewwilai L, Wannachai N, Brenden N, Truong DD, Devahastin R (2011a) Prevalence and diagnostic challenge of dystonia in Thailand: a service-based study in a tertiary university referral centre. Parkinsonism Relat Disord 17(Suppl 1):S15-19. https://doi.org/10.1016/j.parkreldis.2011.06.014
Bhidayasiri R, Panyakaew P, Trenkwalder C, Jeon B, Hattori N, Jagota P, Wu YR, Moro E, Lim SY, Shang H, Rosales R, Lee JY, Thit WM, Tan EK, Lim TT, Tran NT, Binh NT, Phoumindr A, Boonmongkol T, Phokaewvarangkul O, Thongchuam Y, Vorachit S, Plengsri R, Chokpatcharavate M, Fernandez HH (2020a) Delivering patient-centered care in Parkinson’s disease: challenges and consensus from an international panel. Parkinsonism Relat Disord 72:82–87. https://doi.org/10.1016/j.parkreldis.2020.02.013
Bhidayasiri R, Phokaewvarangkul O, Sakdisornchai K, Boonpang K, Chaudhuri KR, Parsons J, Lolekha P, Chairangsaris P, Srivanitchapoom P, Benedierks S, Panyakaew P, Boonmongkol T, Thongchuam Y, Kantachadvanich N, Phumphid S, Evans AH, Viriyavejakul A, Pisarnpong A, van Laar T, Jagota P (2020b) Establishing apomorphine treatment in Thailand: understanding the challenges and opportunities of Parkinson’s disease management in developing countries. Expert Rev Neurother 20(6):523–537. https://doi.org/10.1080/14737175.2020.1770598
Bhidayasiri R, Virameteekul S, Sukoandari B, Tran TN, Lim TT (2021) Challenges of Parkinson’s disease care in Southeast Asia. In: Riederer P, Laux G (eds) NeuroPsychopharmacotherapy. Springer Nature Switzerland AG, pp 1–21
Bhidayasiri R, Wannachai N, Limpabandhu S, Choeytim S, Suchonwanich Y, Tananyakul S, Tharathep C, Panjapiyakul P, Srismith R, Chimabutra K, Phanthumchinda K, Asawavichienjinda T (2011b) A national registry to determine the distribution and prevalence of Parkinson’s disease in Thailand: implications of urbanization and pesticides as risk factors for Parkinson’s disease. Neuroepidemiology 37(3–4):222–230. https://doi.org/10.1159/000334440
Bongioanni P, Del Carratore R, Corbianco S, Diana A, Cavallini G, Masciandaro SM, Dini M, Buizza R (2021) Climate change and neurodegenerative diseases. Environ Res 201:111511. https://doi.org/10.1016/j.envres.2021.111511
Bongioanni P, Del Carratore R, Dolciotti C, Diana A, Buizza R (2022) Effects of global warming on patients with dementia, motor neuron or Parkinson’s Diseases: a comparison among cortical and subcortical disorders. Int J Environ Res Public Health. https://doi.org/10.3390/ijerph192013429
Collaborators GN (2019) Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 18(5):459–480. https://doi.org/10.1016/S1474-4422(18)30499-X
Collaborators GND (2017) Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurol 16(11):877–897. https://doi.org/10.1016/S1474-4422(17)30299-5
Collaborators GPsD (2018) Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 17(11):939–953. https://doi.org/10.1016/S1474-4422(18)30295-3
Comella C, Bhatia K (2015) An international survey of patients with cervical dystonia. J Neurol 262(4):837–848. https://doi.org/10.1007/s00415-014-7586-2
Daher M (2015) Patient rights. In: Encyclopedia of global bioethics. Springer Science+Business Media, Dordrecht
Division UNDoEaSAP (2019) World population prospects 2019
Dorsey ER, Constantinescu R, Thompson JP, Biglan KM, Holloway RG, Kieburtz K, Marshall FJ, Ravina BM, Schifitto G, Siderowf A, Tanner CM (2007) Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology 68(5):384–386. https://doi.org/10.1212/01.wnl.0000247740.47667.03
Dotchin CL, Msuya O, Walker RW (2007) The challenge of Parkinson’s disease management in Africa. Age Ageing 36(2):122–127. https://doi.org/10.1093/ageing/afl172
Fereshtehnejad SM, Rodriguez-Violante M, Ponce-Rivera MS, Martinez-Ramirez D, Ramirez-Zamora A (2022) COVID-19 and integrated multidisciplinary care model in Parkinson’s disease: literature review & future perspectives. Behav Sci (basel). https://doi.org/10.3390/bs12110447
Gunnarsson LG, Bodin L (2019) Occupational exposures and neurodegenerative diseases—a systematic literature review and meta-analyses. Int J Environ Res Public Health. https://doi.org/10.3390/ijerph16030337
Ha ULN, Tran TN, Le M, Dang THT, Vu NA, Truong D (2019) Validating the vietnamese version of wearing—Off 19 questionnaire for patients with Parkinson’s disease. Clin Park Relat Disord 1:37–40. https://doi.org/10.1016/j.prdoa.2019.07.007
Hopkins HK, Traverse EM, Barr KL (2022) Viral Parkinsonism: an underdiagnosed neurological complication of Dengue virus infection. PLoS Negl Trop Dis 16(2):e0010118. https://doi.org/10.1371/journal.pntd.0010118
Jitkritsadakul O, Boonrod N, Bhidayasiri R (2017) Knowledge, attitudes and perceptions of Parkinson’s disease: a cross-sectional survey of Asian patients. J Neurol Sci 374:69–74. https://doi.org/10.1016/j.jns.2016.12.063
Kumar A (2002) Movement disorders in the tropics. Parkinsonism Relat Disord 9(2):69–75. https://doi.org/10.1016/s1353-8020(02)00055-x
Lim SY, Tan AH, Ahmad-Annuar A, Klein C, Tan LCS, Rosales RL, Bhidayasiri R, Wu YR, Shang HF, Evans AH, Pal PK, Hattori N, Tan CT, Jeon B, Tan EK, Lang AE (2019) Parkinson’s disease in the Western Pacific Region. Lancet Neurol 18(9):865–879. https://doi.org/10.1016/S1474-4422(19)30195-4
Lolekha P, Phanthumchinda K, Bhidayasiri R (2010) Prevalence and risk factors of Parkinson’s disease in retired Thai traditional boxers. Mov Disord 25(12):1895–1901. https://doi.org/10.1002/mds.23210
Ma CL, Su L, Xie JJ, Long JX, Wu P, Gu L (2014) The prevalence and incidence of Parkinson’s disease in China: a systematic review and meta-analysis. J Neural Transm (vienna) 121(2):123–134. https://doi.org/10.1007/s00702-013-1092-z
Mitchell M, Kan L (2019) Digital technology and the future of health systems. Health Syst Reform 5(2):113–120. https://doi.org/10.1080/23288604.2019.1583040
Monje MHG, Dominguez S, Vera-Olmos J, Antonini A, Mestre TA, Malpica N, Sanchez-Ferro A (2021) Remote evaluation of Parkinson’s Disease using a conventional webcam and artificial intelligence. Front Neurol 12:742654. https://doi.org/10.3389/fneur.2021.742654
Muangpaisan W, Hori H, Brayne C (2009) Systematic review of the prevalence and incidence of Parkinson’s disease in Asia. J Epidemiol 19(6):281–293. https://doi.org/10.2188/jea.je20081034
Phokaewvarangkul O, Vorachit S, Phoumindr A, Keosodsay S, Postuma RB, Meissner WG, Bhidayasiri R (2020) Addressing knowledge gaps in Parkinson’s disease: a report on the Movement Disorder Society’s Centre-to-Centre initiative to improve Parkinson’s disease services in Lao People’s Democratic Republic. BMC Med Educ 20(1):239. https://doi.org/10.1186/s12909-020-02161-x
Pringsheim T, Jette N, Frolkis A, Steeves TD (2014) The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov Disord 29(13):1583–1590. https://doi.org/10.1002/mds.25945
Rossi A, Berger K, Chen H, Leslie D, Mailman RB, Huang X (2018) Projection of the prevalence of Parkinson’s disease in the coming decades: revisited. Mov Disord 33(1):156–159. https://doi.org/10.1002/mds.27063
Saitoh Y, Mizusawa H (2022) Current evidence for the association between air pollution and Parkinson’s disease. Ann Indian Acad Neurol 25(Suppl 1):S41–S46. https://doi.org/10.4103/aian.aian_62_22
Sakamoto R, Tanimoto T, Takahashi K, Hamaki T, Kusumi E, Crump A (2019) Flourishing Japanese encephalitis, associated with global warming and urbanisation in Asia, demands widespread integrated vaccination programmes. Ann Glob Health. https://doi.org/10.5334/aogh.2580
Santiago JA, Bottero V, Potashkin JA (2017) Biological and clinical implications of comorbidities in Parkinson’s disease. Front Aging Neurosci 9:394. https://doi.org/10.3389/fnagi.2017.00394
Schiess N, Cataldi R, Okun MS, Fothergill-Misbah N, Dorsey ER, Bloem BR, Barretto M, Bhidayasiri R, Brown R, Chishimba L, Chowdhary N, Coslov M, Cubo E, Di Rocco A, Dolhun R, Dowrick C, Fung VSC, Gershanik OS, Gifford L, Gordon J, Khalil H, Kuhn AA, Lew S, Lim SY, Marano MM, Micallef J, Mokaya J, Moukheiber E, Nwabuobi L, Okubadejo N, Pal PK, Shah H, Shalash A, Sherer T, Siddiqui B, Thompson T, Ullrich A, Walker R, Dua T (2022) Six action steps to address global disparities in Parkinson disease: a world health organization priority. JAMA Neurol. https://doi.org/10.1001/jamaneurol.2022.1783
Suarez-Cedeno G, Pantelyat A, Mills KA, Murthy M, Alshaikh JT, Rosenthal LS, Bang J, Moukheiber E (2021) Movement disorders virtual fellowship training in times of coronavirus disease 2019: a single-center experience. Telemed J E Health 27(10):1160–1165. https://doi.org/10.1089/tmj.2020.0419
Tan AH, Tan CT, Marras C, Loh KW, Wye Ho NW, Lim QH, Tan PW, Lim CC, Cheong YW, Kong ST, Schee JP, Tan KH, Soo SK, Vanderschaaf C, Lai Heong Lew S, Mahamad UA, Goh KJ, Yong HS, Lim SY (2015) Knowledge of Parkinson’s disease in a multiethnic urban Asian setting. J Parkinsons Dis 5(4):865–879. https://doi.org/10.3233/JPD-150594
Tan LC, Venketasubramanian N, Hong CY, Sahadevan S, Chin JJ, Krishnamoorthy ES, Tan AK, Saw SM (2004) Prevalence of Parkinson disease in Singapore: Chinese vs Malays vs Indians. Neurology 62(11):1999–2004. https://doi.org/10.1212/01.wnl.0000128090.79756.10
Tangamornsuksan W, Lohitnavy O, Sruamsiri R, Chaiyakunapruk N, Norman Scholfield C, Reisfeld B, Lohitnavy M (2019) Paraquat exposure and Parkinson’s disease: a systematic review and meta-analysis. Arch Environ Occup Health 74(5):225–238. https://doi.org/10.1080/19338244.2018.1492894
van den Bergh R, Bloem BR, Meinders MJ, Evers LJW (2021) The state of telemedicine for persons with Parkinson’s disease. Curr Opin Neurol 34(4):589–597. https://doi.org/10.1097/WCO.0000000000000953
Vellingiri B, Chandrasekhar M, Sri Sabari S, Gopalakrishnan AV, Narayanasamy A, Venkatesan D, Iyer M, Kesari K, Dey A (2022) Neurotoxicity of pesticides—a link to neurodegeneration. Ecotoxicol Environ Saf 243:113972. https://doi.org/10.1016/j.ecoenv.2022.113972
Wanneveich M, Moisan F, Jacqmin-Gadda H, Elbaz A, Joly P (2018) Projections of prevalence, lifetime risk, and life expectancy of Parkinson’s disease (2010–2030) in France. Mov Disord 33(9):1449–1455. https://doi.org/10.1002/mds.27447
Zhang Y, Ma Y, Feng F, Cheng B, Wang H, Shen J, Jiao H (2021) Association between PM10 and specific circulatory system diseases in China. Sci Rep 11(1):12129. https://doi.org/10.1038/s41598-021-91637-x
Acknowledgements
Editorial assistance in the preparation of this manuscript was provided by Dr. Karen Wolstencroft.
Funding
Roongroj Bhidayasiri and this study is supported by Senior Research Scholar Grant (RTA6280016) of the Thailand Science Research and Innovation (TSRI), International Research Network Grant of the Thailand Research Fund (IRN59W0005), and Center of Excellence grant of Chulalongkorn University (GCE 6100930004-1).
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RB had the original idea for the article; RB and JS performed the literature search and data analysis; all authors contributed to drafting and critically revising the article, and approved it for submission.
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Roongroj Bhidayasiri has received consultancy and/or honoraria/lecture fees from Abbott, Boehringer-Ingelheim, Britannia, Ipsen, Novartis, Teva-Lundbeck, Takeda, and Otsuka pharmaceuticals; he has received research funding from the Newton Fund, the UK Government, Thailand Science and Research Innovation Bureau, Thailand Research Fund, Crown Property Bureau, Chulalongkorn University, and the National Science and Technology Development Agency; he holds patents for laser-guided walking stick, portable tremor device, nocturnal monitoring, and electronic Parkinson’s disease symptom diary as well as copyright on dopamine lyrics and teaching video clips for common nocturnal and gastrointestinal symptoms for Parkinson’s disease. Raymond Rosales has received consultancy and/or honoraria/lecture fees from Ipsen, Otsuka, Novartis, and Sun Pharmaceuticals; he has received research funding from University of Santo Tomas Research Center for Health Sciences, Philippines. Tai Ngoc Tran has received consultancy and/or honoraria/lecture fees from Boehringer-Ingelheim, Ipsen, and Medtronic; he has received research funding from University Medical Centre, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam. All other authors have no relevant financial or non-financial interests to disclose.
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Bhidayasiri, R., Sringean, J., Van Le, T. et al. Movement disorders in Indochina: Resource challenges and future solutions. J Neural Transm 130, 875–889 (2023). https://doi.org/10.1007/s00702-023-02662-1
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DOI: https://doi.org/10.1007/s00702-023-02662-1