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Recent trends in mental illness and omega-3 fatty acids

  • Psychiatry and Preclinical Psychiatric Studies - Review Article
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Abstract

Although it is clear that nutrition affects physical and metabolic functions in humans, the importance of nutrition in mental illness has often been overlooked. Following a report by Hibbeln (Lancet 351:1213, 1998) published in The Lancet, which suggested that depression rates and fish consumption were inversely correlated, the relationships between a variety of nutritional/epidemiological treatments and neuropsychiatric disorders have received increased attention. In particular, many studies have been conducted on the omega-3 fatty acid mechanism of action in pathophysiological aspects of various neuropsychiatric disorders. Furthermore, many clinical studies have also been conducted on the effects of omega-3 replacement therapy. Therefore, this article reports recent trends in, and perspectives on, the use of omega-3 fatty acids to treat the five psychiatric disorders: schizophrenia (a delusion of the psychotic zone), depression and other mood disorders, attention deficit hyperactivity disorder (a developmental disorder), post-traumatic stress disorder (psychological trauma after the disaster), and Alzheimer-type dementia.

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References

  • Allinson TM, Parkin ET, Turner AJ, Hooper NM (2003) ADAMs family members as amyloid precursor protein alpha-secretases. J Neurosci Res 74(3):342–352

    CAS  PubMed  Google Scholar 

  • Amodeo G, Trusso MA, Fagiolini A (2017) Depression and inflammation: disentangling a clear yet complex and multifaceted link. Neuropsychiatry 7(4):448–457

    Google Scholar 

  • Appleton KM, Rogers PJ, Ness AR (2010) Updated systematic review and meta-analysis of the effects of n–3 long-chain polyunsaturated fatty acids on depressed mood. Am J Clin Nutr 91(3):757–770

    CAS  PubMed  Google Scholar 

  • Arvindakshan M, Sitasawad S, Debsikdar V, Ghate M, Evans D, Horrobin DF, Bennett C, Ranjekar PK, Mahadik SP (2003) Essential polyunsaturated fatty acid and lipid peroxide levels in never-medicated and medicated schizophrenia patients. Biol Psychiatry 53(1):56–64

    CAS  PubMed  Google Scholar 

  • Bazinet RP, Layé S (2014) Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci 15(12):771–785

    CAS  PubMed  Google Scholar 

  • Beydoun MA, Beydoun HA, Gamaldo AA, Teel A, Zonderman AB, Wang Y (2014) Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis. BMC Public Health 14:643

    PubMed  PubMed Central  Google Scholar 

  • Bloch MH, Qawasmi A (2011) Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry 50(10):991–1000

    PubMed  PubMed Central  Google Scholar 

  • Bloch MH, Hannestad J (2012) Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis. Mol Psychiatry 17(12):1272–1282

    CAS  PubMed  Google Scholar 

  • Burckhardt M, Herke M, Wustmann T, Watzke S, Langer G, Fink A (2016) Omega-3 fatty acids for the treatment of dementia. Cochrane Database Syst Rev 4:CD009002. https://doi.org/10.1002/14651858.CD009002.pub3

    Article  PubMed  Google Scholar 

  • Casali BT, Corona AW, Mariani MM, Colleen Karlo J, Ghosal K, Landreth GE (2015) Omega-3 fatty acids augment the actions of nuclear receptor agonists in a mouse model of Alzheimer’s disease. J Neurosci 35(24):9173–9181

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cederholm T (2017) Fish consumption and omega-3 fatty acid supplementation for prevention or treatment of cognitive decline, dementia or Alzheimer's disease in older adults—any news? Curr Opin Clin Nutr Metab Care 20(2):104–109

    CAS  PubMed  Google Scholar 

  • Chen CT, Bazinet RP (2015) β-oxidation and rapid metabolism, but not uptake regulate brain eicosapentaenoic acid levels. Prostaglandins Leukot Essent Fatty Acids 92:33–40

    CAS  PubMed  Google Scholar 

  • Chen AT, Chibnall JT, Nasrallah HA (2015) A meta-analysis of placebo-controlled trials of omega-3 fatty acid augmentation in schizophrenia: Possible stage-specific effects. Ann Clin Psychiatry 27(4):289–296

    PubMed  Google Scholar 

  • Cooper RE, Tye C, Kuntsi J, Vassos E, Asherson P (2016) The effect of omega-3 polyunsaturated fatty acid supplementation on emotional dysregulation, oppositional behaviour and conduct problems in ADHD: a systematic review and meta-analysis. J Affect Disord 190:474–482

    CAS  PubMed  Google Scholar 

  • Davies C, Cipriani A, Ioannidis JPA, Radua J, Stahl D, Provenzani U, McGuire P, Fusar-Poli P (2018) Lack of evidence to favor specific preventive interventions in psychosis: a network meta-analysis. World Psychiatry 17(2):196–209

    PubMed  PubMed Central  Google Scholar 

  • Doty RL, Bayona EA, Leon-Ariza DS, Cuadros J, Chung I, Vazquez B, Leon-Sarmiento FE (2014) The lateralized smell test for detecting Alzheimer's disease: failure to replicate. J Neurol Sci 340(1–2):170–173

    PubMed  PubMed Central  Google Scholar 

  • Freeman MP, Hibbeln JR, Wisner KL, Davis JM, Mischoulon D, Peet M, Keck PE Jr, Marangell LB, Richardson AJ, Lake J, Stoll AL (2006) Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J Clin Psychiatry 67:1954–1967

    CAS  PubMed  Google Scholar 

  • Hashimoto K (2010) Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions. Psychiatry Clin Neurosci 64(4):341–357

    CAS  PubMed  Google Scholar 

  • Hawkey E, Nigg JT (2014) Omega-3 fatty acid and ADHD: blood level analysis and meta-analytic extension of supplementation trials. Clin Psychol Rev 34(6):496–505

    PubMed  PubMed Central  Google Scholar 

  • Heras-Sandoval D, Pedraza-Chaverri J, Pérez-Rojas JM (2016) Role of docosahexaenoic acid in the modulation of glial cells in Alzheimer’s disease. J Neuroinflammation 13:61

    PubMed  PubMed Central  Google Scholar 

  • Heude B, Ducimetiere P, Berr C, EVA Study (2003) Cognitive decline and fatty acid composition of erythrocyte membranes: the EVA Study. Am J Clin Nutr 77(4):803–808

    CAS  PubMed  Google Scholar 

  • Hibbeln J (1998) Fish consumption and major depression (letter). Lancet 351:1213

    CAS  PubMed  Google Scholar 

  • Hibbeln J, Salem N (1995) Dietary polyunsaturatedfatty acids and depression: when cholesterol does not satisfy. Am J Clin Nutr 62:1–9

    CAS  PubMed  Google Scholar 

  • Jiao J, Li Q, Chu J, Zeng W, Yang M, Zhu S (2014) Effect of n-3 PUFA supplementation on cognitive function throughout the life span from infancy to old age: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 100(6):1422–1436

    CAS  PubMed  Google Scholar 

  • Lafourcade M, Larrieu T, Mato S, Duffaud A, Sepers M, Matias I, De Smedt-Peyrusse V, Labrousse VF, Bretillon L, Matute C, Rodríguez-Puertas R, Layé S, Manzoni OJ (2011) Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nat Neurosci 14(3):345–350

    CAS  PubMed  Google Scholar 

  • Liao Y, Xie B, Zhang H, He Q, Guo L, Subramaniapillai M, Fan B, Lu C, Mclntyer RS (2019) Efficacy of omega-3 PUFAs in depression: a meta-analysis. Transl Psychiatry 9(1):190

    PubMed  PubMed Central  Google Scholar 

  • Lin PY, Huang SY, Su KP (2010) A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol Psychiatry 68(2):140–147

    CAS  PubMed  Google Scholar 

  • Lin LE, Chen CT, Hildebrand KD, Liu Z, Hopperton KE, Bazinet RP (2015) Chronic dietary n-6 PUFA deprivation leads to conservation of arachidonic acid and more rapid loss of DHA in rat brain phospholipids. J Lipid Res 56(2):390–402

    CAS  PubMed  PubMed Central  Google Scholar 

  • Marszalek JR, Lodish HF (2005) Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you. Annu Rev Cell Dev Biol 21:633–657

    CAS  PubMed  Google Scholar 

  • Martins JG, Bentsen H, Puri BK (2012) Eicosapentaenoic acid appears to be the key omega-3 fatty acid component associated with efficacy in major depressive disorder: a critique of Bloch and Hannestad and updated meta-analysis. Mol Psychiatry 17(12):1144–1149 (discussion 1163–1167)

    CAS  PubMed  Google Scholar 

  • Matsuoka Y (2011) Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: a novel preventive strategy for posttraumatic stress disorder? Biopsychosoc Med 5:3

    CAS  PubMed  PubMed Central  Google Scholar 

  • McGrath-Hanna NK, Greene DM, Tavernier RJ, Bult-Ito A (2003) Diet and mental health in the Arctic: is diet an important risk factor for mental health in circumpolar peoples?–A review. Int J Circumpolar Health 62(3):228–241

    PubMed  Google Scholar 

  • McNamara RK (2009) Evaluation of docosahexaenoic acid deficiency as a preventable risk factor for recurrent affective disorders: current status, future directions, and dietary recommendations. Prostaglandins Leukot Essent Fatty Acids 81(2–3):223–231

    CAS  PubMed  Google Scholar 

  • McNamara RK, Carlson SE (2006) Role of omega-3 fatty acids in brain development and function: Potential implications for the pathogenesis and prevention of psychopathology. Prostaglandins Leukot Essent Fatty Acids 75:329–349

    CAS  PubMed  Google Scholar 

  • McNamara RK, Jandacek R, Rider T, Tso P, Hahn CG, Richtand NM, Stanford KE (2007) Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender dif ferences and partial normalization with antipsychotic medications. Schizophr Res 91(1–3):37–50

    PubMed  PubMed Central  Google Scholar 

  • Mucke L, Selkoe DJ (2012) Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. Cold Spring Harb Perspect Med 2(7):a006338

    PubMed  PubMed Central  Google Scholar 

  • Nishi D, Koido Y, Nakaya N, Sone T, Noguchi H, Hamazaki, Hamazaki T, Matsuoka Y (2012) Fish oil for attenuating posttraumatic stress symptoms among rescue workers after the great east Japan earthquake: a randomized controlled trial. Psychother Psychosom 81:315–317

    PubMed  Google Scholar 

  • Neale BM, Medland SE, Ripke S, Asherson P, Franke B, Lesch K-P, Faraone SV, Nguyen TT, Schäfer H, Holmans P, Daly M, Steinhausen H-C, Freitag C, Reif A, Renner TJ, Romanos M, Romanos J, Walitza S, Warnke A, Meyer J, Palmason H, Buitelaar J, Vasquez AA, Lambregts-Rommelse N, Gill M, Anney RJL, Langely K, O'Donovan M, Williams N, Owen M, Thapar A, Kent L, Sergeant J, Roeyers H, Mick E, Biederman J, Doyle A, Smalley S, Loo S, Hakonarson H, Elia J, Todorov A, Miranda A, Mulas F, Ebstein RP, Rothenberger A, Banaschewski T, Oades RD, Sonuga-Barke E, McGough J, Nisenbaum L, Middleton F, Hu X, Nelson S (2010) Meta-analysis of genome-wide association studies of attention deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49(9):884–897

    PubMed  PubMed Central  Google Scholar 

  • Nicola SM, Surmeier J, Malenka RC (2000) Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens. Annu Rev Neurosci 23:185–215

    CAS  PubMed  Google Scholar 

  • Puri BK, Martins JG (2014) Which polyunsaturated fatty acids are active in children with attention-deficit hyperactivity disorder receiving PUFA supplementation? A fatty acid validated meta-regression analysis of randomized controlled trials. Prostaglandins Leukot Essent Fatty Acids 90:179–189

    CAS  PubMed  Google Scholar 

  • Reed-Geaghan EG, Savage JC, Hise AG, Landreth GE (2009) CD14 and toll-like receptors 2 and 4 are required for fibrillar A{β}-stimulated microglial activation. J Neurosci 29(38):11982–11992

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ross BM, McKenzie I, Glen I, Bennett CP (2003) Increased levels of ethane, a non-invasive marker of n–3 fatty acid oxidation, in breath of children with attention deficit hyperactivity disorder. Nutr Neurosci 6(5):277–281

    CAS  PubMed  Google Scholar 

  • Sanders TA (2000) Polyunsaturated fatty acids in the food chain in Europe. Am J Clin Nutr 71(1 Suppl):176S–S178

    CAS  PubMed  Google Scholar 

  • Sarris J, Logan AC, Akbaraly TN, Amminger GP, Balanzá-Martínez V, Freeman MP, Hibbeln J, Matsuoka Y, Mischoulon D, Mizoue T, Nanri A, Nishi D, Ramsey D, Rucklidge JJ, Sanchez-Villegas A, Scholey A, Su KP, Jacka FN (2015) Nutritional medicine as mainstream in psychiatry. Lancet Psychiatry 2(3):271–274

    PubMed  Google Scholar 

  • Serhan CN, Arita M, Hong S, Gotlinger K (2004) Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. Lipids 39(11):1125–1132

    CAS  PubMed  Google Scholar 

  • Sonuga-Barke EJ, Brandeis D, Cortese S, Daley D, Ferrin M, Holtmann M, Stevenson J, Danckaerts M, van der Oord S, Döpfner M, Dittmann RW, Simonoff E, Zuddas A, Banaschewski T, Buitelaar J, Coghill D, Hollis C, Konofal E, Lecendreux M, Wong IC, Sergeant J, European ADHD, Guidelines Group (2013) d controlled trials of dietary and psychological treatments. Am J Psychiatry 170(3):275–289

    PubMed  Google Scholar 

  • Su KP (2009) Biological mechanism of antidepressant effect of omega-3 fatty acids: how does fish oil act as a 'mind-body interface'? Neurosignals 17(2):144–152

    CAS  PubMed  Google Scholar 

  • Su KP (2012) Inflammation in psychopathology of depression: clinical, biological, and therapeutic implications. Bio Med 2:68–74

    Google Scholar 

  • Su KP, Lai HC, Yang HT, Su WP, Peng CY, Chang JP, Chang HC, Pariante CM (2014) Omega-3 fatty acids in the prevention of interferon-alpha-induced depression: results from a randomized, controlled trial. Biol Psychiatry 76(7):559–566

    CAS  PubMed  Google Scholar 

  • Su KP, Matsuoka Y, Pae CU (2015) Omega-3 polyunsaturated fatty acids in prevention of mood and anxiety disorders. Clin Psychopharmacol Neurosci 13(2):129–137

    CAS  PubMed  PubMed Central  Google Scholar 

  • Suhara T, Okubo Y, Yasuno F, Sudo Y, Inoue M, Ichimiya T, Nakashima Y, Nakayama K, Tanada S, Suzuki K, Halldin C, Farde L (2002) Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia. Arch Gen Psychiatry 59(1):25–30

    CAS  PubMed  Google Scholar 

  • Van der Kemp WJ, Klomp DW, Kahn RS, Luijten PR, Hulshoff Pol HE (2012) A meta-analysis of the polyunsaturated fatty acid composition of erythrocyte membranes in schizophrenia. Schizophr Res 141(2–3):153–161

    PubMed  Google Scholar 

  • Wilensky AE, Schafe GE, Kristensen MP, LeDoux JE (2006) Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning. J Neurosci 26(48):12387–12396

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wolf A, Bauer B, Hartz AMS (2012) ABC transporters and the Alzheimer’s disease enigma. Front Psychiatry. https://doi.org/10.3389/fpsyt.2012.00054

    Article  PubMed  PubMed Central  Google Scholar 

  • Yamada D, Takeo J, Koppensteiner P, Wada K, Sekiguchi M (2014) Modulation of fear memory by dietary polyunsaturated fatty acids via cannabinoid receptors. Neuropsychopharmacology 39(8):1852–1860

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zimmer L, Hembert S, Durand G, Breton P, Guilloteau D, Besnard JC, Chalon S (1998) Chronic n–3 polyunsaturated fatty acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study. Neurosci Lett 240(3):177–181

    CAS  PubMed  Google Scholar 

  • Zimmer L, Delion-Vancassel S, Durand G, Guilloteau D, Bodard S, Besnard JC, Chalon S (2000) Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient in n–3 polyunsaturated fatty acids. J Lipid Res 41(1):32–40

    CAS  PubMed  Google Scholar 

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Correspondence to Ken Yonezawa.

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Yonezawa, K., Kusumoto, Y., Kanchi, N. et al. Recent trends in mental illness and omega-3 fatty acids. J Neural Transm 127, 1491–1499 (2020). https://doi.org/10.1007/s00702-020-02212-z

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