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Different response to instrumental tests in relation to cognitive demand after dopaminergic stimulation in previously treated patients with Parkinson’s disease

  • Neurology and Preclinical Neurological Studies - Original Article
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Abstract

Instrumental measurement of response assets and movement behaviour gained importance as addition to rating procedures to determine the efficacy of therapeutic interventions in patients with Parkinson’s disease. Objectives were to determine the response to standardised 100 mg levodopa application with repeat performance of complex and simple instrumental tests in relation to scored motor behaviour in 53 previously treated patients. Levodopa improved rating scores of motor impairment, execution of complicated movement patterns and complex reaction time. Computed improvements in these instrumental test results correlated with each other. Execution of the simple reaction time paradigm and of plain movement sequences did not ameliorate after levodopa. The changes of these simple test results were not associated to each other. These different response patterns result from the higher cognitive demand of dopamine sensitive association areas of the prefrontal cortex and mesolimbic system for the complex test execution in contrast to the simple task performance.

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Acknowledgement

We thank Tanja Steiner, Bettina Marchewitz, Gudrun Edler, Ute Claussnitzer and Christine Stamm for technical assistance. We thank the participating PD patients.

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Authors and Affiliations

  1. Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstr. 1, 13088, Berlin, Germany

    Thomas Müller

  2. Private Practice for Neurosurgery, MVZ PAN Institute GmbH within the Department of Neurosurgery, Pan Klinik Am Neumarkt, Zeppelinstr 1 Neumarkt-Galerie, 50667, Cologne, Germany

    Ali Harati

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Correspondence to Thomas Müller.

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Müller, T., Harati, A. Different response to instrumental tests in relation to cognitive demand after dopaminergic stimulation in previously treated patients with Parkinson’s disease. J Neural Transm 127, 265–272 (2020). https://doi.org/10.1007/s00702-020-02148-4

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