Impact of orthostatic hypotension on wheelchair use in patients with Parkinson’s disease

Nakamura, Tomohiko; Suzuki, Masashi; Ueda, Masamichi; Harada, Yumiko; Hirayama, Masaaki; Katsuno, Masahisa

doi:10.1007/s00702-019-02127-4

Neurology and Preclinical Neurological Studies - Short communication
Published: 23 December 2019

Impact of orthostatic hypotension on wheelchair use in patients with Parkinson’s disease

Tomohiko Nakamura ORCID: orcid.org/0000-0001-7622-4527^1,2,
Masashi Suzuki¹,
Masamichi Ueda¹,
Yumiko Harada¹,
Masaaki Hirayama³ &
Masahisa Katsuno¹

Journal of Neural Transmission volume 127, pages 379–383 (2020)Cite this article

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Abstract

Wheelchair use is an important indicator of disease progression in Parkinson’s disease (PD). Here, we investigated whether orthostatic hypotension (OH) affects the time to wheelchair use. We examined 33 PD patients with OH and 95 without OH. Median time to start using a wheelchair calculated from the time of disease onset was significantly shorter in patients with OH than in those without OH (12.0 vs 19.0 years; p < 0.001). Thus, appropriate management of OH and motor function is necessary.

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Funding

This work was supported by the Japan Society for the Promotion of Science (JSPS KAKENHI Grant no. 16K09713) and a grant from the Ministry of Health, Labor, and Welfare of Japan.

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Affiliations

Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
Tomohiko Nakamura, Masashi Suzuki, Masamichi Ueda, Yumiko Harada & Masahisa Katsuno
Department of Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan
Tomohiko Nakamura
Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan
Masaaki Hirayama

Authors

Tomohiko Nakamura
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Masashi Suzuki
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Masamichi Ueda
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Yumiko Harada
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Masaaki Hirayama
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Masahisa Katsuno
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Correspondence to Tomohiko Nakamura or Masahisa Katsuno.

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Nakamura, T., Suzuki, M., Ueda, M. et al. Impact of orthostatic hypotension on wheelchair use in patients with Parkinson’s disease. J Neural Transm 127, 379–383 (2020). https://doi.org/10.1007/s00702-019-02127-4

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Received: 01 October 2019
Accepted: 16 December 2019
Published: 23 December 2019
Issue Date: March 2020
DOI: https://doi.org/10.1007/s00702-019-02127-4

Keywords

Orthostatic hypotension
Dysautonomia
Parkinson’s disease
Wheelchair
Progression