Abstract
Many pain conditions in patients tend to co-occur, influencing the clinical expressions of each other in various ways. This paper summarizes the main concurrent pain conditions by analyzing the major interactions observed. In particular, co-occurrence will be examined in: visceral pain (especially ischemic heart disease, irritable bowel syndrome, dysmenorrhea/endometriosis and urinary pain), fibromyalgia, musculoskeletal pain and headache. Two concurrent visceral pains from internal organs sharing at least part of their central sensory projection can give rise to viscero-visceral hyperalgesia, i.e., enhancement of typical pain symptoms from both districts. Visceral pain, headache and musculoskeletal pains (myofascial pain from trigger points, joint pain) can enhance pain and hyperalgesia from fibromyalgia. Myofascial pain from trigger points can perpetuate pain symptoms from visceral pain conditions and trigger migraine attacks when located in the referred pain area from an internal organ or in cervico-facial areas, respectively. The pathophysiology of these pain associations is complex and probably multifactorial; among the possible processes underlying the mutual influence of symptoms recorded in the associations is modulation of central sensitization phenomena by nociceptive inputs from one or the other condition. A strong message in these pain syndrome co-occurrence is that effective treatment of one of the conditions can also improve symptoms from the other, thus suggesting a systematic and thorough evaluation of the pain patient for a global effective management of his/her suffering.
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References
Aamodt AH, Stovner LJ, Hagen K, Zwart JA (2008) Comorbidity of headache and gastrointestinal complaints. Head HUNT Study. Cephalalgia 28:144–151
Adelborg K, Szépligeti SK, Holland-Bill L, Ehrenstein V, Horváth-Puhó E, Henderson VW, Sørensen HT (2018) Migraine and risk of cardiovascular diseases: Danish population based matched cohort study. BMJ 360:k96
Affaitati G, Vecchiet F, Lerza R, De Laurentis S, Iezzi S, Festa F, Giamberardino MA (2001) Effects of topical diclofenac (DHEP plaster) on skin, subcutis and muscle pain thresholds in subjects without spontaneous pain. Drugs Exp Clin Res 27(2):69–76
Affaitati G, Giamberardino MA, Lerza R, Lapenna D, De Laurentis S, Vecchiet L (2002) Effects of tramadol on behavioural indicators of colic pain in a rat model of ureteral calculosis. Fundam Clin Pharmacol 16(1):23–30
Affaitati G, Fabrizio A, Savini A, Lerza R, Tafuri E, Costantini R, Lapenna D, Giamberardino MA (2009) A randomized, controlled study comparing a lidocaine patch, a placebo patch, and anesthetic injection for treatment of trigger points in patients with myofascial pain syndrome: evaluation of pain and somatic pain thresholds. Clin Ther 31(4):705–720
Affaitati G, Costantini R, Fabrizio A, Lapenna D, Tafuri E, Giamberardino MA (2011) Effects of treatment of peripheral pain generators in fibromyalgia patients. Eur J Pain 15:61–69
Affaitati G, Fabrizio A, Frangione V, Lanzarotti A, Lopopolo M, Tafuri E, Lapenna D, Giamberardino MA, Costantini R (2015) Effects of topical diclofenac plus heparin (DHEP + H plaster) on somatic pain sensitivity in healthy subjects with a latent algogenic condition of the lower limb. Pain Pract 15(1):58–67
Affaitati G, Martelletti P, Lopopolo M, Tana C, Massimini F, Cipollone F, Lapenna D, Giamberardino MA, Costantini R (2017) Use of nonsteroidal anti-inflammatory drugs for symptomatic treatment of episodic headache. Pain Pract 17(3):392–401
Affaitati G, Costantini R, Tana C, Lapenna D, Schiavone C, Cipollone F, Giamberardino MA (2018a) Effects of topical vs injection treatment of cervical myofascial trigger points on headache symptoms in migraine patients: a retrospective analysis. J Headache Pain 19(1):104
Affaitati G, Giamberardino MA, Lapenna D, Costantini R (2018b) Diclofenac epolamine topical patch for the treatment of pain. J Biol Regul Homeost Agents 32(3):435–441
Alabousi A, Patlas MN, Mellnick VM, Chernyak V, Farshait N, Katz DS (2019) Renal colic imaging: myths, recent trends, and controversies. Can Assoc Radiol J 70(2):164–171
Aloisi AM, Affaitati G, Ceccarelli I, Fiorenzani P, Lerza R, Rossi C, Pace MC, Chiefari M, Aurilio C, Giamberardino MA (2010) Estradiol and testosterone differently affect visceral pain-related behavioural responses in male and female rats. Eur J Pain 14(6):602–607
Alonso-Blanco C, Fernández-de-las-Peñas C, Morales-Cabezas M, Zarco-Moreno P, Ge HY, Florez-García M (2011) Multiple active myofascial trigger points reproduce the overall spontaneous pain pattern in women with fibromyalgia and are related to widespread mechanical hypersensitivity. Clin J Pain 27(5):405–413
Altman G, Cain KC, Motzer S, Jarrett M, Burr R, Heitkemper M (2006) Increased symptoms in female IBS patients with dysmenorrhea and PMS. Gastroenterol Nurs 29:4–11
Alvarez DJ, Rockwell PG (2002) Trigger points: diagnosis and management. Am Fam Physician 65:653–660
American Headache Society (2019) The American Headache Society position statement on integrating new migraine treatments into clinical practice. Headache 59:1–18
Ammons WS, Blair RW, Foreman RD (1984) Responses of primate T1–T5 spinothalamic neurons to gallbladder distension. Am J Physiol 247:995–1002
Arendt-Nielsen L, Schipper KP, Dimcevski G, Sumikura H, Krarup AL, Giamberardino MA, Drewes AM (2008) Viscero-somatic reflexes in referred pain areas evoked by capsaicin stimulation of the human gut. Eur J Pain 12(5):544–551
Aziz Q, Giamberardino MA (2017) Visceral pain comorbidity in headache. In: Martelletti P, Giamberardino MA (eds) Comorbidities in headache disorders. Springer International Publishing, Switzerland, pp 65–84
Aziz Q, Giamberardino MA, Barke A, Korwisi B, Baranowski AP, Wesselmann U, Rief W, Treede RD (2019) IASP Taskforce for the Classification of Chronic Pain The IASP classification of chronic pain for ICD-11: chronic secondary visceral pain. Pain 160(1):69–76
Bajaj P, Bajaj P, Madsen H, Arendt-Nielsen L (2003) Endometriosis is associated with central sensitization: a psychophysical controlled study. J Pain 4(7):372–380
Baranowski AP (2009) Chronic pelvic pain. Best Pract Res Clin Gastroenterol 23:593–610
Bartolini M, Giamberardino MA, Lisotto C, Martelletti P, Moscato D, Panascia B, Savi L, Pini LA, Sances G, Santoro P, Zanchin G, Omboni S, Ferrari MD, Brighina F, Fierro B (2011) A double-blind, randomized, multicenter, Italian study of frovatriptan versus almotriptan for the acute treatment of migraine. J Headache Pain 12(3):361–368
Berkley KJ (2005) A life of pelvic pain. Physiol Behav 86:272–280
Berkley KJ, Cason A, Jacobs H, Bradshaw HB, Wood E (2001) Vaginal hyperalgesia in a rat model of endometriosis. Neurosci Lett 306:185–188
Bezov D, Ashina S, Jensen R, Bendtsen L (2011) Pain perception studies in tension-type headache. Headache 51:262–271
Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M, Lipton RB (2010) Migraine and cardiovascular disease: a population-based study. Neurology 4(8):628–635
Bonica JJ (ed) (1990) The management of pain, 2nd edn. Lea & Febiger, Philadephia
Brinkert W, Dimcevski G, Arendt-Nielsen L, Drewes AM, Wilder-Smith OH (2007) Dysmenorrhoea is associated with hypersensitivity in the sigmoid colon and rectum. Pain 132:S46–S51
Brumovsky PR, Gebhart GF (2010) Visceral organ cross-sensitization: an integrated perspective. Auton Neurosci 153:106–115
Cabo-Meseguer A, Cerdá-Olmedo G, Trillo-Mata JL (2017) Fibromyalgia: prevalence, epidemiologic profiles and economic costs. Med Clin (Barc) 149:441–448
Cakit BD, Taskin S, Nacir B, Unlu I, Genc H, Erdem HR (2010) Comorbidity of fibromyalgia and cervical myofascial pain. Clin Rheumatol 29:405–411
Caldarella MP, Giamberardino MA, Sacco F, Affaitati G, Milano A, Lerza R, Balatsinou C, Laterza F, Pierdomenico SD, Cuccurullo F, Neri M (2006) Sensitivity disturbances in patients with irritable bowel syndrome and fibromyalgia. Am J Gastroenterol 101(12):2782–2789
Cassisi G, Sarzi-Puttini P, Alciati A, Casale R, Bazzichi L, Carignola R, Gracely RH, Salaffi F, Marinangeli F, Torta R, Giamberardino MA, Buskila D, Spath M, Cazzola M, Di Franco M, Biasi G, Stisi S, Altomonte L, Arioli G, Leardini G, Gorla R, Marsico A, Ceccherelli F, Atzeni F, Network Italian Fibromyalgia (2008) Symptoms and signs in fibromyalgia syndrome. Reumatismo 60(Suppl 1):15–24
Castro Sánchez AM, García López H, Fernández Sánchez M, Pérez Mármol JM, Aguilar-Ferrándiz ME, Luque Suárez A, Matarán Peñarrocha GA (2009) Improvement in clinical outcomes after dry needling versus myofascial release on pain pressure thresholds, quality of life, fatigue, pain intensity, quality of sleep, anxiety, and depression in patients with fibromyalgia syndrome. Disabil Rehabil 41(19):2235–2246
Centonze V, Polito BM, Cassiano MA, Doronzo F, Ricchetti G, Portincasa P, Bassi A, Albano O (1996) The dyspeptic syndrome in migraine: morphofunctional evaluation on 53 patients. Headache 36:442–445
Cervero F (2000) Visceral pain-central sensitization. Gut 47:56–57
Cervero F, Laird JM (2004) Understanding the signaling and transmission of visceral nociceptive events. J Neurobiol 61:45–54
Chaban VV (2008) Visceral sensory neurons that innervate both uterus and colon express nociceptive TRPV1 and P2X3 receptors in rats. Ethn Dis 18:S220–S224
Chaban V, Christensen A, Wakamatsu M, McDonald M, Rapkin A, McDonald J, Micevych P (2007) The same dorsal root ganglion neurons innervate uterus and colon in the rat. NeuroReport 18:209–212
Cho S-J, Sohn J-H, Bae JS, Chu MK (2017) Fibromyalgia Among Patients With Chronic Migraine and Chronic Tension-Type Headache: a Multicenter Prospective Cross-Sectional Study. Headache 57:1583–1592
Chung MK, Chung RP, Gordon D (2005) Interstitial cystitis and endometriosis in patients with chronic pelvic pain: the “Evil Twins” syndrome. JSLS 9(1):25–29
Cole JA, Rothman KJ, Cabral HJ, Zhang Y, Farraye FA (2006) Migraine, fibromyalgia, and depression among people with IBS: a prevalence study. BMC Gastroenterol 6:26
Colson NJ, Lea RA, Quinlan S, Griffiths LR (2006) No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G polymorphisms in migraine susceptibility. BMC Med Genet 7:12
Coppola G, Di Lorenzo C, Schoenen J, Pierelli F (2013) Habituation and sensitization in primary headaches. J Headache Pain 14:65
Costantini R, Di Bartolomeo N, Francomano F, Angelucci D, Innocenti P (2005a) Epithelioid angiosarcoma of the gallbladder: case report. J Gastrointest Surg 9(6):822–825
Costantini R, Sardellone A, Marino C, Giamberardino MA, Innocenti P, Napolitano AM (2005b) Vacuum-assisted core biopsy (Mammotome) for the diagnosis of non-palpable breast lesions: four-year experience in an Italian center. Tumori 91(4):351–354
Costantini R, De Nicola P, Bianco F, Cotroneo AR, Iezzi R, Di Bartolomeo N, Innocenti P (2007) Tumor vs non-tumor origin of occult and obscure gastrointestinal bleeding requiring hospitalization. Tumori 93(5):461–466
Costantini R, Affaitati G, Fabrizio A, Giamberardino MA (2011) Controlling pain in the post-operative setting. Int J Clin Pharmacol Ther 49(2):116–127
Costantini R, Caldaralo F, Palmieri C, Napolitano L, Aceto L, Cellini C, Innocenti P (2012) Risk factors for conversion of laparoscopic cholecystectomy. Ann Ital Chir 83(3):245–252
Costantini R, Affaitati G, Massimini F, Tana C, Innocenti P, Giamberardino MA (2016) Laparoscopic Cholecystectomy for Gallbladder Calculosis in Fibromyalgia Patients: impact on Musculoskeletal Pain, Somatic Hyperalgesia and Central Sensitization. PLoS ONE 11(4):e0153408. https://doi.org/10.1371/journal.pone.0153408
Costantini R, Affaitati G, Wesselmann U, Czakanski P, Giamberardino MA (2017) Visceral pain as a triggering factor for fibromyalgia symptoms in comorbid patients. Pain 158(10):1925–1937
Couppe C, Midttun A, Hilden J, Jorgensen U, Oxholm P, Fuglsang-Frederiksen A (2001) Spontaneous needle electromyographic activity in myofascial trigger points in the infraspinatus muscle: a blinded assessment. J Musculoske Pain 9:7–16
Cummings M (2007) Regional myofascial pain: diagnosis and management. Best Pract Res Clin Rheumatol 21(2):367–387
Dahan A, van Velzen M, Niesters M (2014) Comorbidities and the complexities of chronic pain. Anesthesiology 121(4):675–677
de Tommaso M (2012) Prevalence, clinical features and potential therapies for fibromyalgia in primary headaches. Expert Rev Neurother 12:287–295
de Tommaso M, Sardaro M, Vecchio E, Serpino C, Stasi M, Ranieri M (2008) Central sensitisation phenomena in primary headaches: overview of a preventive therapeutic approach. CNS Neurol Disord: Drug Targets 7:524–535
de Tommaso M, Sardaro M, Serpino C, Costantini F, Vecchio E, Prudenzano MP, Lamberti P, Livrea P (2009) Fibromyalgia comorbidity in primary headaches. Cephalalgia 29:453–464
de Tommaso M, Federici A, Loiacono A, Delussi M, Todarello O (2014) Personality profiles and coping styles in migraine patients with fibromyalgia comorbidity. Compr Psychiatry 55:80–86
Dimitrova AK, Ungaro RC, Lebwohl B, Lewis SK, Tennyson CA, Green MW, Babyatsky MW, Green PH (2013) Prevalence of migraine in patients with celiac disease and inflammatory bowel disease. Headache 53:344–355
Do TP, Heldarskard GF, Kolding LT, Hvedstrup J, Schytz HW (2018) Myofascial trigger points in migraine and tension-type headache. J Headache Pain 19(1):84
Dommerholt J, Hooks T, Chou LW, Finnegan M (2019) A critical overview of the current myofascial pain literature - November 2018. J Bodyw Mov Ther 23(1):65–73
Drewes AM, Jennum P (1995) Epidemiology of myofascial pain, low back pain, morning stiffness and sleep-related complaints in the general population. J Musculoske Pain 3(1):121
Duffield SJ, Ellis BM, Goodson N, Walker-Bone K, Conaghan PG, Margham T, Loftis T (2017) The contribution of musculoskeletal disorders in multimorbidity: implications for practice and policy. Best Pract Res Clin Rheumatol 31(2):129–144
Evans SF, Brooks TA, Esterman AJ, Hull ML, Rolan PE (2018) The comorbidities of dysmenorrhea: a clinical survey comparing symptom profile in women with and without endometriosis. J Pain Res 11:3181–3194
Fan YH, Lin AT, Lu SH, Chuang YC, Chen KK (2014) Non-bladder conditions in female Taiwanese patients with interstitial cystitis/hypersensitive bladder syndrome. Int J Urol 21(8):805–809
Fariello JY, Moldwin RM (2015) Similarities between interstitial cystitis/bladder pain syndrome and vulvodynia: implications for patient management. Transl Androl Urol 4(6):643–652
Fernández-de-Las-Peñas C, Dommerholt J (2018) International Consensus on Diagnostic Criteria and Clinical Considerations of Myofascial Trigger Points: a Delphi Study. Pain Med 19(1):142–150
Fernández-de-Las-Peñas C, Ge HY, Alonso-Blanco C, Gonzalez-Iglesias J, Arendt-Nielsen L (2010) Referred pain areas of active myofascial trigger points in head, neck and shoulder muscles, in chronic tension type headache. J Bodyw Mov Ther 14:391–396
Ferrero S, Pretta S, Bertoldi S, Anserini P, Remorgida V, Del Sette M, Gandolfo C, Ragni N (2004) Increased frequency of migraine among women with endometriosis. Hum Reprod 19(12):2927–2932
Festi D, Dormi A, Capodicasa S, Staniscia T, Attili AF, Loria P, Pazzi P, Gazzella G, Sama C, Roda E, Colecchia A (2008) Incidence of gallstone disease in Italy: results from a multicenter, population based Italian study (the MICOL project). World J Gastroenterol 14:5282–5289
Filatova E, Latysheva N, Kurenkov A (2008) Evidence of persistent central sensitization in chronic headaches: a multi-method study. J Headache Pain 9:295–300
Frøkjaer JB, Andersen SD, Gale J, Arendt-Nielsen L, Gregersen H, Drewes AM (2005) An experimental study of viscero-visceral hyperalgesia using an ultrasound-based multimodal sensory testing approach. Pain 119:191–200
García-Leiva JM, Hidalgo J, Rico-Villademoros F, Moreno V, Calandre EP (2007) Effectiveness of ropivacaine trigger points inactivation in the prophylactic management of patients with severe migraine. Pain Med 8(1):65–70
Ge HY, Nie H, Madeleine P, Danneskiold-Samsøe B, Graven-Nielsen T, Arendt-Nielsen L (2009) Contribution of the local and referred pain from active myofascial trigger points in fibromyalgia syndrome. Pain 147:233–240
Ge HY, Wang Y, Fernández-de-las-Peñas C, Graven-Nielsen T, Danneskiold-Samsøe B, Arendt-Nielsen L (2011) Reproduction of overall spontaneous pain pattern by manual stimulation of active myofascial trigger points in fibromyalgia patients. Arthritis Res Ther 13(2):R48
Gebhart GF, Bielefeldt K (2016) Physiology of Visceral Pain. Compr Physiol 6(4):1609–1633
Georgiou I, Syrrou M, Bouba I, Dalkalitsis N, Paschopoulos M, Navrozoglou I, Lolis D (1999) Association of estrogen receptor gene polymorphisms with endometriosis. Fertil Steril 1:164–166
Gerwin RD (1999) Myofascial pain syndromes from trigger points. Curr Rev Pain 3:153–159
Gerwin RD (2001) Classification, epidemiology, and natural history of myofascial pain syndrome. Curr Pain Headache Rep 5:412–420
Gerwin RD (2016) Myofascial Trigger Point Pain Syndromes. Semin Neurol 36(5):469–473
Giamberardino MA (2008) Women and visceral pain: are the reproductive organs the main protagonists? Mini-review at the occasion of the “European Week Against Pain in Women 2007”. Eur J Pain 12(3):257–260
Giamberardino MA, Costantini R (2017) Challenging chronic migraine: targeting the CGRP receptor. Lancet Neurol 16(6):410–411
Giamberardino MA, Jensen T (eds) (2012) Pain comorbidities: understanding and treating the complex patient. IASP Press, Seattle, pp 1–518
Giamberardino MA, Martelletti P (2015) Emerging drugs for migraine treatment. Expert Opin Emerg Drugs 20(1):137–147
Giamberardino MA, Vecchiet L (1995) Visceral pain, referred hyperalgesia and outcome: new concepts. Eur J Anaesthesiol Suppl 10:61–66
Giamberardino MA, de Bigontina P, Martegiani C, Vecchiet L (1994) Effects of extracorporeal shock-wave lithotripsy on referred hyperalgesia from renal/ureteral calculosis. Pain 56:77–83
Giamberardino MA, Dragani L, Valente R, Di Lisa F, Saggini R, Vecchiet L (1996) Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. Int J Sports Med 17(5):320–324
Giamberardino MA, Berkley KJ, Iezzi S, de Bigontina P, Vecchiet L (1997) Pain threshold variations in somatic wall tissues as a function of menstrual cycle, segmental site and tissue depth in non-dysmenorrheic women, dysmenorrheic women and men. Pain 71(2):187–197
Giamberardino MA, De Laurentis S, Affaitati G, Lerza R, Lapenna D, Vecchiet L (2001) Modulation of pain and hyperalgesia from the urinary tract by algogenic conditions of the reproductive organs in women. Neurosci Lett 304:61–64
Giamberardino MA, Berkley KJ, Affaitati G, Lerza R, Centurione L, Lapenna D, Vecchiet L (2002) Influence of endometriosis on pain behaviors and muscle hyperalgesia induced by a ureteral calculosis in female rats. Pain 95(3):247–257
Giamberardino MA, Affaitati G, Lerza R, Lapenna D, Costantini R, Vecchiet L (2005) Relationship between pain symptoms and referred sensory and trophic changes in patients with gallbladder pathology. Pain 114(1–2):239–249
Giamberardino MA, Affaitati G, Costantini R (2006) Chapter 24. Referred pain from internal organs. Handbook of Clinical Neurology 81:343–361
Giamberardino MA, Tafuri E, Savini A, Fabrizio A, Affaitati G, Lerza R, Di Ianni L, Lapenna D, Mezzetti A (2007) Contribution of myofascial trigger points to migraine symptoms. J Pain 8(11):869–878
Giamberardino MA, Affaitati G, Costantini R (2010a) Visceral referred pain. J Musculoske. Pain 18:403–410
Giamberardino MA, Costantini R, Affaitati G, Fabrizio A, Lapenna D, Tafuri E, Mezzetti A (2010b) Viscero-visceral hyperalgesia: characterization in different clinical models. Pain 151(2):307–322
Giamberardino MA, Affaitati G, Fabrizio A, Costantini R (2011a) Effects of treatment of myofascial trigger points on the pain of fibromyalgia. Curr Pain Headache Rep 15(5):393–399
Giamberardino MA, Affaitati G, Fabrizio A, Costantini R (2011b) Myofascial pain syndromes and their evaluation. Best Pract Res Clin Rheumatol 25(2):185–198
Giamberardino MA, Affaitati G, Costantini R (2012) Concurrent visceral pain syndromes: the concept of viscero-visceral hyperalgesia. In: Giamberardino MA, Jensen TS (eds) Pain comorbidities: Understanding and treating the complex patient. IASP Press, Seattle, pp 309–330
Giamberardino MA, Tana C, Costantini R (2014) Pain thresholds in women with chronic pelvic pain. Curr Opin Obstet Gynecol 26(4):253–259
Giamberardino MA, Affaitati G, Martelletti P, Tana C, Negro A, Lapenna D, Curto M, Schiavone C, Stellin L, Cipollone F, Costantini R (2015) Impact of migraine on fibromyalgia symptoms. J Headache Pain. 17:28
Giamberardino MA, Affaitati G, Curto M, Negro A, Costantini R, Martelletti P (2016) Anti-CGRP monoclonal antibodies in migraine: current perspectives. Intern Emerg Med 11(8):1045–1057
Giamberardino MA, Affaitati G, Costantini R, Cipollone F, Martelletti P (2017) Calcitonin gene-related peptide receptor as a novel target for the management of people with episodic migraine: current evidence and safety profile of erenumab. J Pain Res 10:2751–2760
Graff-Radford SB (2004) Myofascial pain: diagnosis and management. Curr Pain Headache Rep 8:463–467
Grayston R, Czanner G, Elhadd K, Goebel A, Frank B, Üçeyler N, Malik RA, Alam U (2019) A systematic review and meta-analysis of the prevalence of small fiber pathology in fibromyalgia: implications for a new paradigm in fibromyalgia etiopathogenesis. Semin Arthritis Rheum 48:933–940
Graziano E, Hagemeier J, Weinstock-Guttman B, Ramasamy DP, Zivadinov R (2015) Increased contrast enhancing lesion activity in relapsing-remitting multiple sclerosis migraine patients. NeuroImage Clin 9:110–116
Greenland P, Alpert JS, Beller GA, Benjamin EJ, Budoff MJ, Fayad ZA, Foster E, Hlatky MA, Hodgson JM, Kushner FG, Lauer MS, Shaw LJ, Smith SC Jr, Taylor AJ, Weintraub WS, Wenger NK, Jacobs AK, Smith SC Jr, Anderson JL, Albert N, Buller CE, Creager MA, Ettinger SM, Guyton RA, Halperin JL, Hochman JS, Kushner FG, Nishimura R, Ohman EM, Page RL et al (2010) 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 56(25):e50–e103
Halder SLS, Locke GR III (2009) Epidemiology and social impact of visceral pain. In: Giamberardino MA (ed) Visceral pain:clinical, pathophysiological and therapeutic aspects. Oxford University Press, Oxford, pp 1–8
Häuser W, Marschall U, Layer P, Grobe T (2019) The Prevalence, Comorbidity, Management and Costs of Irritable Bowel Syndrome. Dtsch Arztebl Int 116(27–28):463–470
Headache Classification Committee of the International Headache Society (IHS) (2018) The international classification of headache disorders, 3rd edition. Cephalalgia 38:1–211
Heidari F, Afshari M, Moosazadeh M (2017) Prevalence of fibromyalgia in general population and patients, a systematic review and meta-analysis. Rheumatol Int 37:1527–1539
Heitkemper MM, Jarrett ME (2008) Update on irritable bowel syndrome and gender differences. Nutr Clin Pract 23:275–283
Hejazi RA, McCallum RW (2011) Review article: cyclic vomiting syndrome in adults: rediscovering and redefining an old entity. Aliment Pharmacol Ther 4:263–273
Hong C-Z, Chen Y-N, Twehous DA, Hong D (1996) Pressure threshold for referred pain by compression on the trigger point and adjacent areas. J Musculoske Pain 4:61–79
Houghton LA, Lea R, Jackson N, Whorwell PJ (2002) The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers. Gut 50:471–474
Iacovides S, Avidon I, Baker FC (2015) What we know about primary dysmenorrhea today: a critical review. Hum Reprod Update 21(6):762–778
Iuvone T, Affaitati G, De Filippis D, Lopopolo M, Grassia G, Lapenna D, Negro L, Costantini R, Vaia M, Cipollone F, Ialenti A, Giamberardino MA (2016) Ultramicronized palmitoylethanolamide reduces viscerovisceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis: role of mast cells. Pain 157(1):80–91
Jarrell J, Giamberardino MA, Robert M, Nasr-Esfahani M (2011) Bedside testing for chronic pelvic pain: discriminating visceral from somatic pain. Pain Res Treat 2011:692102
Jarrell J, Ross S, Robert M, Wood S, Tang S, Stephanson K, Giamberardino MA (2014) Prediction of postoperative pain after gynecologic laparoscopy for nonacute pelvic pain. Am J Obstet Gynecol 211(4):360.e1–360.e8
Johnson CM, Makai GEH (2018) Fibromyalgia and Irritable Bowel Syndrome in Female Pelvic Pain. Semin Reprod Med 36(2):136–142
Kahriman A, Zhu S (2018) Migraine and Tension-Type Headache. Semin Neurol 38(6):608–618
Kato K, Sullivan PF, Evengard B, Pedersen NL (2006) Chronic widespread pain and its comorbidities: a population-based study. Arch Intern Med 166:1649–1654
Katz VL (2007) Endometriosis. In: Katz VL (ed) Comprehensive gynecology, 5th edn. Philadelphia, Mosby Elsevier, MD Consult
Kaunisto MA, Kallela M, Hamalainen E, Kilpikari R, Havanka H, Harno H, Nissilä M, Säkö E, Ilmavirta M, Liukkonen J, Teirmaa H, Törnwall O, Jussila M, Terwilliger J, Färkkilä M, Kaprio J, Palotie A, Wessman M (2006) Testing of variants of the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association with migraine with aura. Cephalalgia 26(12):1462–1472
Kim HJ (2016) Update on the pathology and diagnosis of interstitial cystitis/bladder pain syndrome: a review. Int Neurourol J 20(1):13–17
Kim SH, Choi YM, Jun JK, Kim JG, Moon SY (2005) Estrogen receptor dinucleotide repeat polymorphism is associated with minimal or mild endometriosis. Fertil Steril 84(3):774–777
Kuan TS (2009) Current studies on myofascial pain syndrome. Curr Pain Headache Rep 13:365–369
Küçükşen S, Genç E, Yılmaz H, Sallı A, Gezer İA, Karahan AY, Salbaş E, Cingöz HT, Nas Ö, Uğurlu H (2013) The prevalence of fibromyalgia and its relation with headache characteristics in episodic migraine. Clin Rheumatol 32:983–990
Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE (2006) Migraine and risk of cardiovascular disease in women. JAMA 296(3):283–291
Kurth T, Gaziano JM, Cook NR, Bubes V, Logroscino G, Diener HC, Buring JE (2007) Migraine and risk of cardiovascular disease in men. Arch Intern Med 167(8):795–801
Kurth T, Diener HC, Buring JE (2011) Migraine and cardiovascular disease in women and the role of aspirin: subgroup analyses in the Women’s Health Study. Cephalalgia 31(10):1106–1115
Lackner JM, Ma C-X, Keefer LA, Brenner DM, Gudleski GD, Satchidanand N, Firth R, Sitrin MD, Katz L, Krasner SS, Ballou SK, Naliboff BD, Mayer EA (2013) Type, rather than number, of mental and physical comorbidities increases the severity of symptoms in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 11(9):1147–1157
Leo MM, Langlois BK, Pare JR, Mitchell P, Linden J, Nelson KP, Amanti C, Carmody KA (2017) Ultrasound vs. computed tomography for severity of hydronephrosis and its importance in renal colic. West J Emerg Med 18(4):559–668
Li J, Micevych P, McDonald J, Rapkin A, Chaban V (2008) Inflammation in the uterus induces phosphorylated extracellular signal-regulated kinase and substance P immunoreactivity in dorsal root ganglia neurons innervating both uterus and colon in rats. J Neurosci Res 86:2746–2752
Lichtenstein A, Tiosano S, Amital H (2018) The complexities of fibromyalgia and its comorbidities. Curr Opin Rheumatol 30(1):94–100
Loeser JD (2001) Bonica’s management of pain. Lippincott, Williams & Wilkins, Philadelphia
Lopopolo M, Affaitati G, Fabrizio A, Massimini F, Lapenna D, Giamberardino MA, Costantini R (2014) Effects of tramadol on viscero-visceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis. Fundam Clin Pharmacol 28(3):331–341
Lucas N, Macaskill P, Irwing L, Moran R, Bogduk N (2009) Reliability of physical examination for diagnosis of myofascial trigger points: a systematic review of the literature. Clin J Pain 25:80–89
Maggioni F, Palmieri A, Tropea M, Zanchin G (2008) Influence of physiologic hormonal modification and of hormonal treatment in a patient with a history of migraine with aura. J Headache Pain 9(2):129–131
Majlesi J, Unalan H (2010) Effect of treatment on trigger points. Curr Pain Headache Rep 14:353–360
Malykhina AP (2007) Neural mechanisms of pelvic organ cross-sensitization. Neuroscience 149(3):660–672
Malykhina AP (2012) Experimental animal models of pain and non-pain comorbidities. In: Giamberardino MA, Jensen TS (eds) Pain comorbidities: Understanding and treating the complex patient. IASP Press, Seattle, pp 37–56
Malykhina AP, Qin C, Greenwood-van Meerveld B, Foreman RD, Lupu F, Akbarali HI (2006) Hyperexcitability of convergent colon and bladder dorsal root ganglion neurons after colonic inflammation: mechanism for pelvic organ cross-talk. Neurogastroenterol Motil 18:936–948
Mannix LK (2008) Menstrual-related pain conditions: dysmenorrhea and migraine. J Womens Health (Larchmt) 17(5):879–891
Marcus DA, Bhowmick A (2013) Fibromyalgia comorbidity in a community sample of adults with migraine. Clin Rheumatol 32:1553–1556
Marjoribanks J, Ayeleke RO, Farquhar C, Proctor M (2015) Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Database Syst Rev 7:CD001751
Marson L, Giamberardino MA, Costantini R, Czakanski P, Wesselmann U (2013) Animal models for the study of female sexual dysfunction. Sex Med Rev 1(2):108–122
Matalliotakis IM, Cakmak H, Fragouli YG, Goumenou AG, Mahutte NG, Arici A (2008) Epidemiological characteristics in women with and without endometriosis in the Yale series. Arch Gynecol Obstet 277(5):389–393
Mense S, Simons DG, Russell IJ (2001) Muscle pain. Understanding its nature, diagnosis, and treatment. Lippincott, Williams & Wilkins, Philadelphia
Merskey H (2012) Introduction. In: Giamberardino MA, Jensen TS (eds) Pain comorbidities. Understanding and treating the complex patient. IASP Press, Seattle, pp 1–17
Meucci G, Radaelli F, Prada A, Bortoli A, Crotta S, Cerrato C, Minoli G (2005) Increased prevalence of migraine in patients with uninvestigated dyspepsia referred for open access upper gastrointestinal endoscopy. Endoscopy 37:622–625
Milligan ED, Watkins LR (2009) Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 10:23–36
Möhrke J, Kropp P, Zettl UK (2013) Headaches in multiple sclerosis patients might imply an inflammatorial process. PLoS One 8:e69570
Moisset X, Ouchchane L, Guy N, Bayle DJ, Dallel R, Clavelou P (2013) Migraine headaches and pain with neuropathic characteristics: comorbid conditions in patients with multiple sclerosis. Pain 154:2691–2699
Moisset X, Bommelaer G, Boube M, Ouchchane L, Goutte M, Dapoigny M, Dallel R, Guttmann A, Clavelou P, Buisson A (2017) Migraine prevalence in inflammatory bowel disease patients: a tertiary-care centre cross-sectional study. Eur J Pain 21(9):1550–1560
Money S (2017) Pathophysiology of trigger points in myofascial pain syndrome. J Pain Palliat Care Pharmacother 31(2):158–159
Morrison T, Dmitrieva N, Winnard KP, Berkley KJ (2006) Opposing viscerovisceral effects of surgically induced endometriosis and a control abdominal surgery on the rat bladder. Fertil Steril 86:1067–1073
Munakata J, Naliboff B, Harraf F, Kodner A, Lembo T, Chang L, Silverman DH, Mayer EA (1997) Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome. Gastroenterology 112(1):55–63
Nicholas M, Vlaeyen JWS, Rief W, Barke A, Aziz Q, Benoliel R, Cohen M, Evers S, Giamberardino MA, Goebel A, Korwisi B, Perrot S, Svensson P, Wang SJ, Treede RD, IASP taskforce for the classification of chronic pain (2019) The IASP classification of chronic pain for ICD-11: chronic primary pain. Pain 160(1):28–37
Nierenburg Hdel C, Ailani J, Malloy M, Siavoshi S, Hu NN, Yusuf N (2015) Systematic review of preventive and acute treatment of menstrual migraine. Headache 55(8):1052–1071
Nunes FR, Ferreira JM, Bahamondes L (2014) Prevalence of fibromyalgia and quality of life in women with and without endometriosis. Gynecol Endocrinol 30:307–310
Nyholt DR, Gillespie NG, Merikangas KR, Treloar SA, Martin NG, Montgomery GW (2009) Common genetic influences underlie comorbidity of migraine and endometriosis. Genet Epidemiol 33(2):105–113
Oaklander AL, Herzog ZD, Downs HM, Klein MM (2013) Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia. Pain 154:2310–2316
Onder H, Hamamci M, Alpua M, Ulusoy EK (2019) Comorbid fibromyalgia in migraine patients: clinical significance and impact on daily life. Neurol Res 20:1–7
Panerai AE, Vecchiet J, Panzeri P, Meroni P, Scarone S, Pizzigallo E, Giamberardino MA, Sacerdote P (2002) Peripheral blood mononuclear cell beta-endorphin concentration is decreased in chronic fatigue syndrome and fibromyalgia but not in depression: preliminary report. Clin J Pain 18(4):270–273
Park JW, Cho Y-S, Lee SY, Kim E-S, Cho H, Shin HE, Suh GI, Choi M-G (2013) Concomitant functional gastrointestinal symptoms influence psychological status in Korean migraine patients. Gut Liver 7(6):668–674
Parthasarathy S, Sundar S, Mishra G (2019) Assessment of predisposing factors in myofascial pain syndrome and the analgesic effect of trigger point injections—a primary therapeutic interventional clinical trial. Indian J Anaesth 63(4):300–303
Pezzone MA, Liang R, Fraser MO (2005) A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders. Gastroenterology 128:1953–1964
Podichetty VK, Mazanec DJ, Biscup RS (2003) Chronic non-malignant musculoskeletal pain in older adults: clinical issues and opioid intervention. Postgrad Med J 79:627–633
Pomes LM, Guglielmetti M, Bertamino E, Simmaco M, Borro M, Martelletti P (2019) Optimising migraine treatment: from drug–drug interactions to personalized medicine. J Headache Pain 20(1):56
Procacci P, Zoppi M, Maresca M (1986) Clinical approach to visceral sensation. In: Cervero F, Morrison JFB (eds) Visceral sensation. Progress in brain research. Elsevier, Amsterdam, pp 21–28
Qin C, Malykhina AP, Thompson AM, Farber JP, Foreman RD (2010) Cross-organ sensitization of thoracic spinal neurons receiving noxious cardiac input in rats with gastroesophageal reflux. Am J Physiol Gastrointest Liver Physiol 298:934–942
Reeves JL, Jaeger B, Graff-Radford A (1986) Reliability of the pressure algometer as a measure of myofascial trigger point sensitivity. Pain 24:313–321
Rist PM, Tzourio C, Kurth T (2011) Associations between lipid levels and migraine: cross-sectional analysis in the epidemiology of vascular ageing study. Cephalalgia 31(14):1459–1465
Rodríguez-Osorio X, Sobrino T, Brea D, Martínez F, Leira CJ (2012) Endothelial progenitor cells: a new key for endothelial dysfunction in migraine. Neurology 79(5):474–479
Sacco S, Ricci S, Carolei A (2011) Tension-type headache and systemic medical disorders. Curr Pain Headache Rep 15:438–443
Sacco S, Ornello R, Ripa P, Tiseo C, Degan D, Pistoia F, Carolei A (2015) Migraine and risk of ischaemic heart disease: a systematic review and meta-analysis of observational studies. Eur J Neurol 22(6):1001–1011
Saggini R, Bellomo RG, Affaitati G, Lapenna D, Giamberardino MA (2007) Sensory and biomechanical characterization of two painful syndromes in the heel. J Pain 8(3):215–222
Sandner P, Tinel H, Affaitati G, Costantini R, Giamberardino MA (2015) Effects of PDE5 inhibitors and sGC stimulators in a rat model of artificial ureteral calculosis. PLoS One 10(10):e0141477
Sasmaz Mİ, Kirpat V (2019) The relationship between the severity of pain and stone size, hydronephrosis and laboratory parameters in renal colic attack. Am J Emerg Med. https://doi.org/10.1016/j.ajem.2019.06.013. (Epub ahead of print)
Schmidt-Hansen PT, Svensson P, Bendtsen L, Graven-Nielsen T, Bach FW (2007) Increased muscle pain sensitivity in patients with tension-type headache. Pain 129:113–121
Scott NA, Guo B, Barton PM, Gerwin RD (2009) Trigger point injections for chronic non-malignant musculoskeletal pain: a systematic review. Pain Med 10(1):54–69
Scripter C (2018) Headache: tension-type headache. FP Essent 473:17–20
Sengupta JN (2009) Visceral pain: the neurophysiological mechanism. Handb Exp Pharmacol 194:131–174
Serra J, Collado A, Solà R, Antonelli F, Torres X, Salgueiro M, Quiles C, Bostock H (2014) Hyperexcitable C nociceptors in fibromyalgia. Ann Neurol 75:196–208
Shah JP, Phillips TM, Danoff JV, Gerber LH (2005) A in vivo microanalytical technique for measuring the local biochemical mileu of human skeletal muscle. J Appl Physiol 99:1977–1984
Shimomura T, Kowa H, Nakano T, Kitano A, Marukawa H, Urakami K, Takahashi K (1994) Platelet superoxide dismutase in migraine and tension-type headache. Cephalalgia 14(3):215–218
Simons DG (1990) Muscular pain syndromes. Adv Pain Res Ther 17:1–41
Simons DG (2008) New views of myofascial trigger points: etiology and diagnosis. Arch Phys Med Rehabil 89(1):157–159
Simons DG, Travell JG, Simons LS (1999) Upper half of body. In: Travell & Simons’ myofascial pain and dysfunction. The trigger point manual, 2nd edn, vol 1. Williams & Wilkins, Baltimore, p 1038
Slade GD, Sanders AE, Bair E, Brownstein N, Dampier D, Knott C, Fillingim R, Maixner WO, Smith S, Greenspan J, Dubner R, Ohrbach R (2013) Preclinical episodes of orofacial pain symptoms and their association with health care behaviors in the OPPERA prospective cohort study. Pain 154:750–760
Srbely JZ (2010) New trends in the treatment and management of myofascial pain syndrome. Curr Pain Headache Rep 14:346–352
Stanford EJ, Dell JR, Parsons CL (2007) The emerging presence of interstitial cystitis in gynecologic patients with chronic pelvic pain. Urology 69:53–59
Staud R (2007) Future perspectives: pathogenesis of chronic muscle pain. Best Pract Res Clin Rheumatol 21:581–596
Staud R, Nagel S, Robinson ME, Price DD (2009) Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study. Pain 145:96–104
Steiner TJ, Stovner LJ, Vos T, Jensen R, Katsarava Z (2018) Migraine is first cause of disability in under 50 s: will health politicians now take notice? J Headache Pain 19(1):17
Stickler GB (2005) Relationship between cyclic vomiting syndrome and migraine. Clin Pediatr (Phila) 44:505–508
Stisi S, Cazzola M, Buskila D, Spath M, Giamberardino MA, Sarzi-Puttini P, Arioli G, Alciati A, Leardini G, Gorla R, Marsico A, Ceccherelli F, Bazzichi L, Carignola R, Gracely RH, Salaffi F, Marinangeli F, Torta R, Di Franco M, Biasi G, Cassisi G, Casale R, Altomonte L, Atzeni F (2008) Italian fibromyalgia network. Etiopathogenetic mechanisms of fibromyalgia syndrome. Reumatismo 60(Suppl 1):25–35
Stovner LJ, Ægidius K, Linde M (2011) Endometriosis and headache. Curr Pain Headache Rep 15:415–419
Stratton P, Berkley KJ (2011) Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update 17(3):327–346
Tafuri E, Santovito D, de Nardis V, Marcantonio P, Paganelli C, Affaitati G, Bucci M, Mezzetti A, Giamberardino MA, Cipollone F (2015) MicroRNA profiling in migraine without aura: pilot study. Ann Med 47(6):468–473
Tana C, Tafuri E, Tana M, Martelletti P, Negro A, Affaitati G, Fabrizio A, Costantini R, Mezzetti A, Giamberardino MA (2013) New insights into the cardiovascular risk of migraine and the role of white matter hyperintensities: is gold all that glitters? J Headache Pain 14:9
Tana C, Caulo M, Tafuri E, Di Vincenzo A, Tana M, De Angelis MV, Mezzetti A, Giamberardino MA (2014) Teaching neuroimages: a dangerous complication of spontaneous intracranial hypotension. Neurology 82(11):e94–e95
Tana C, Santilli F, Martelletti P, di Vincenzo A, Cipollone F, Davì G, Giamberardino MA (2015) Correlation between migraine severity and cholesterol levels. Pain Pract 15(7):662–670
Tana C, Giamberardino MA, Cipollone F (2017) microRNA profiling in atherosclerosis, diabetes, and migraine. Ann Med 49(2):93–105
Tchivileva IE, Ohrbach R, Fillingim RB, Greenspan JD, Maixner W, Slade GD (2017) Temporal change in headache and its contribution to the risk of developing first-onset temporomandibular disorder in the orofacial pain: prospective Evaluation and Risk Assessment (OPPERA) study. Pain 158:120–129
Tervila L, Marttila P (1975) Headache as a symptom of endometriosis externa. Ann Chir Gynaecol Fenn 64(4):239–241
Tietjen GE, Bushnell CD, Herial NA, Utley C, White L, Hafeez F (2007) Endometriosis is associated with prevalence of comorbid conditions in migraine. Headache 47(7):1069–1078
Tough EA, White AR, Richards S, Campbell J (2007) Variability of criteria used to diagnose myofascial trigger point syndrome: evidence from a review of literature. Clin J Pain 23:276–286
Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, Cohen M, Evers S, Finnerup NB, First MB, Giamberardino MA, Kaasa S, Korwisi B, Kosek E, Lavandʼhomme P, Nicholas M, Perrot S, Scholz J, Schug S, Smith BH, Svensson P, Vlaeyen JWS, Wang SJ (2019) Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). Pain 160(1):19–27
Treloar SA, Bell TA, Nagle CM, Purdie DM, Green AC (2010) Early menstrual characteristics associated with subsequent diagnosis of endometriosis. Am J Obstet Gynecol 202(6):534 (e1–6)
Vecchiet L, Giamberardino MA, Dragani L, Albe-Fessard D (1989) Pain from renal/ureteral calculosis: evaluation of sensory thresholds in the lumbar area. Pain 36:289–295
Vecchiet L, Giamberardino MA, Dragani L, de Bigontina P, Albe-Fessard D (1990) Latent myofascial trigger points: changes in muscular and subcutaneous pain thresholds at trigger point and target level. J Ma Med 5:151–154
Vecchiet L, Giamberardino MA, Saggini R (1991) Myofascial pain syndromes: clinical and pathophysiological aspects. Clin J Pain 7(Suppl 1):S16–S22
Vecchiet L, Giamberardino MA, de Bigontina P (1992) Referred pain from viscera: when the symptom persists despite the extinction of the visceral focus. Adv Pain Res Ther 20:101–110
Vecchiet L, Montanari G, Pizzigallo E, Iezzi S, de Bigontina P, Dragani L, Vecchiet J, Giamberardino MA (1996) Sensory characterization of somatic parietal tissues in chronic fatigue syndrome. Neurosci Lett 208:117–120
Vecchiet L, Pizzigallo E, Lezzi S, Affaitati G, Vecchiet J, Giamberardino MA (1998) Differentiation of sensitivity in different tissues and its clinical significance. J Musculoske Pain 6(1):33–45
Vera-Portocarrero LP, Ossipov MH, King T, Porreca F (2008) Reversal of inflammatory and noninflammatory visceral pain by central or peripheral actions of sumatriptan. Gastroenterology 135(4):1369–1378
Vij B, Whipple MO, Tepper SJ, Mohabbat AB, Stillman M, Vincent A (2015) Frequency of migraine headaches in patients with fibromyalgia. Headache 55:860–865
Wesselmann U, Czakanski PP, Affaitati G, Giamberardino MA (1998) Uterine inflammation as a noxious visceral stimulus: behavioral characterization in the rat. Neurosci Lett 246(2):73–76
Wilder-Smith CH, Robert-Yap J (2007) Abnormal endogenous pain modulation and somatic and visceral hypersensitivity in female patients with irritable bowel syndrome. World J Gastroenterol 13(27):3699–3704
Winnard KP, Dmitrieva N, Berkley KJ (2006) Cross-organ interactions between reproductive, gastrointestinal, and urinary tracts: modulation by estrous stage and involvement of the hypogastric nerve. Am J Physiol Regul Integr Comp Physiol 291:R1592–R1601
Winsvold BS, Hagen K, Aamodt AH, Stovner LJ, Holmen J, Zwart JA (2011) Headache, migraine and cardiovascular risk factors: the HUNT study. Eur J Neurol 18(3):504–511
Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, Fam AG, Farber SJ, Fiechtner JJ, Franklin CM, Gatter RA, Hamaty D, Lessard J, Lichtbroun AS, Masi AT, Mccain GA, Reynolds WJ, Romano TJ, Russell IJ, Sheon RP (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum 33:160–172
Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, Russell AS, Russell IJ, Winfield JB, Yunus MB (2010) The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken) 62:600–610
Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RL, Mease PJ, Russell AS, Russell IJ, Walitt B (2016) 2016 revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum 46(3):319–329
Xu YM, Ge HY, Arendt-Nielsen L (2010) Sustained nociceptive mechanical stimulation of latent myofascial trigger point induces central sensitization in healthy subjects. J Pain 11:1348–1355
Zohsel K, Hohmeister J, Oelkers-Ax R, Flor H, Hermann C (2006) Quantitative sensory testing in children with migraine: preliminary evidence for enhanced sensitivity to painful stimuli especially in girls. Pain 123:10–18
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Affaitati, G., Costantini, R., Tana, C. et al. Co-occurrence of pain syndromes. J Neural Transm 127, 625–646 (2020). https://doi.org/10.1007/s00702-019-02107-8
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DOI: https://doi.org/10.1007/s00702-019-02107-8