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Reviewing the case for compromised spinal inhibition in neuropathic pain

  • Neurology and Preclinical Neurological Studies - Review Article
  • Published:
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Abstract

A striking and debilitating property of the nervous system is that damage to this tissue can cause chronic intractable pain, which persists long after resolution of the initial insult. This neuropathic form of pain can arise from trauma to peripheral nerves, the spinal cord, or brain. It can also result from neuropathies associated with disease states such as diabetes, human immunodeficiency virus/AIDS, herpes, multiple sclerosis, cancer, and chemotherapy. Regardless of the origin, treatments for neuropathic pain remain inadequate. This continues to drive research into the underlying mechanisms. While the literature shows that dysfunction in numerous loci throughout the CNS can contribute to chronic pain, the spinal cord and in particular inhibitory signalling in this region have remained major research areas. This review focuses on local spinal inhibition provided by dorsal horn interneurons, and how such inhibition is disrupted during the development and maintenance of neuropathic pain.

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Funding

This work was funded by the National Health and Medical Research Council (NHMRC) of Australia (Grant 631000 and 1043933, 1144638 to B.A.G), and the Hunter Medical Research Institute (Grant to B.A.G).

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  1. School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, NSW, 2308, Australia

    M. A. Gradwell, R. J. Callister & B. A. Graham

  2. Hunter Medical Research Institute (HMRI), New Lambton Heights, NSW, Australia

    M. A. Gradwell, R. J. Callister & B. A. Graham

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  1. M. A. Gradwell
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Gradwell, M.A., Callister, R.J. & Graham, B.A. Reviewing the case for compromised spinal inhibition in neuropathic pain. J Neural Transm 127, 481–503 (2020). https://doi.org/10.1007/s00702-019-02090-0

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