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Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship

Journal of Neural Transmission volume 127, pages 647–660 (2020)Cite this article

Abstract

Sleep disturbances and chronic pain are considered public health concerns. They are frequently associated, and the direction of its relationship and possible mechanisms underlying it are frequently debated. The exploration of the sleep–pain association is of great clinical interest to explore in order to steer potential therapeutic avenues, accommodate the patient’s experience, and adapt the common practice of health professionals. In this review, the direction between sleep–pain in adult and pediatric populations will be discussed. Moreover, the possible mechanisms contributing to this relationship as endogenous pain modulation, inflammation, affect, mood and other states, the role of different endogenous substances (dopamine, orexin, melatonin, vitamin D) as well as other lesser known such as cyclic alternating pattern among others, will be explored. Finally, directions for future studies on this area will be discussed, opening up to the addition of tools such as brain imaging (e.g., fMRI), electrophysiology and non-invasive brain stimulation techniques. Such resources paired with artificial intelligence are key to personalized medicine management for patients facing pain and sleep interacting conditions.

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Fig. 1
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Abbreviations

IL-6:

Interleukin 6

CRP:

C-reactive protein

NAc:

Nucleus accumbens

A2A:

Adenosine 2 receptor

PAG:

Periaqueductal gray

EEG:

Electroencephalogram

EMG:

Electromyogram

25OHD:

25-Hydroxyvitamin D

References

  • Adams RJ, Appleton SL, Taylor AW et al (2017) Sleep health of Australian adults in 2016: results of the 2016 Sleep Health Foundation national survey. Sleep Health 3(1):35–42

    PubMed  Google Scholar 

  • Afolalu EF, Ramlee F, Tang NKY (2018) Effects of sleep changes on pain-related health outcomes in the general population: a systematic review of longitudinal studies with exploratory meta-analysis. Sleep Med Rev 39:82–97

    PubMed Central  PubMed  Google Scholar 

  • Andersen ML, Araujo P, Frange C, Tufik S (2018) Sleep disturbance and pain: a tale of two common problems. Chest 154(5):1249–1259

    PubMed  Google Scholar 

  • Arendt-Nielsen L, Sluka KA, Nie HL (2008) Experimental muscle pain impairs descending inhibition. Pain 140(3):465–471

    PubMed Central  PubMed  Google Scholar 

  • Arewasikporn A, Ehde DM, Alschuler KN, Turner AP, Jensen MP (2018) Positive factors, pain, and function in adults with multiple sclerosis. Rehabil Psychol 63(4):612–620

    PubMed Central  PubMed  Google Scholar 

  • Banno M, Harada Y, Taniguchi M et al (2018) Exercise can improve sleep quality: a systematic review and meta-analysis. PeerJ 6:e5172

    PubMed Central  PubMed  Google Scholar 

  • Bastuji H, Perchet C, Legrain V, Montes C, Garcia-Larrea L (2008) Laser evoked responses to painful stimulation persist during sleep and predict subsequent arousals. Pain 137(3):589–599

    CAS  PubMed  Google Scholar 

  • Bentley AJ, Newton S, Zio CD (2003) Sensitivity of sleep stages to painful thermal stimuli. J Sleep Res 12(2):143–147

    CAS  PubMed  Google Scholar 

  • Bergman P, Sperneder S, Hoijer J, Bergqvist J, Bjorkhem-Bergman L (2015) Low vitamin D levels are associated with higher opioid dose in palliative cancer patients—results from an observational study in Sweden. PLoS One 10(5):e0128223

    PubMed Central  PubMed  Google Scholar 

  • Besedovsky L, Lange T, Haack M (2019) The sleep-immune crosstalk in health and disease. Physiol Rev 99(3):1325–1380

    PubMed Central  PubMed  Google Scholar 

  • Bishop TM, Ashrafioun L, Pigeon WR (2018) The association between sleep apnea and suicidal thought and behavior: an analysis of national survey data. J Clin Psychiatry 79(1):17m11480

    PubMed  Google Scholar 

  • Boakye PA, Olechowski C, Rashiq S et al (2016) A critical review of neurobiological factors involved in the interactions between chronic pain, depression, and sleep disruption. Clin J Pain 32(4):327–336

    PubMed  Google Scholar 

  • Bonvanie IJ, Oldehinkel AJ, Rosmalen JG, Janssens KA (2016) Sleep problems and pain: a longitudinal cohort study in emerging adults. Pain 157(4):957–963

    PubMed  Google Scholar 

  • Born J, Lange T, Hansen K, Molle M, Fehm HL (1997) Effects of sleep and circadian rhythm on human circulating immune cells. J Immunol 158(9):4454–4464

    CAS  PubMed  Google Scholar 

  • Buenaver LF, Quartana PJ, Grace EG et al (2012) Evidence for indirect effects of pain catastrophizing on clinical pain among myofascial temporomandibular disorder participants: the mediating role of sleep disturbance. Pain 153(6):1159–1166

    PubMed  Google Scholar 

  • Burgess HJ, Burns JW, Buvanendran A et al (2019) Associations between sleep disturbance and chronic pain intensity and function: a test of direct and indirect pathways. Clin J Pain 35:569–576

    PubMed  PubMed Central  Google Scholar 

  • Cady RJ, Denson JE, Sullivan LQ, Durham PL (2014) Dual orexin receptor antagonist 12 inhibits expression of proteins in neurons and glia implicated in peripheral and central sensitization. Neuroscience 269:79–92

    CAS  PubMed  Google Scholar 

  • Cappuccio FP, Taggart FM, Kandala NB et al (2008) Meta-analysis of short sleep duration and obesity in children and adults. Sleep 31(5):619–626

    PubMed Central  PubMed  Google Scholar 

  • Carra MC, Rompre PH, Kato T et al (2011) Sleep bruxism and sleep arousal: an experimental challenge to assess the role of cyclic alternating pattern. J Oral Rehabil 38(9):635–642

    CAS  PubMed  Google Scholar 

  • Caumo W, Hidalgo MP, Souza A, Torres ILS, Antunes LC (2019) Melatonin is a biomarker of circadian dysregulation and is correlated with major depression and fibromyalgia symptom severity. J Pain Res 12:545–556

    CAS  PubMed Central  PubMed  Google Scholar 

  • Chae CU, Lee RT, Rifai N, Ridker PM (2001) Blood pressure and inflammation in apparently healthy men. Hypertension 38(3):399–403

    CAS  PubMed  Google Scholar 

  • Chokroverty S (2010) Overview of sleep and sleep disorders. Indian J Med Res 131:126–140

    CAS  PubMed  Google Scholar 

  • Chouchou F, Chauny JM, Rainville P, Lavigne GJ (2015) Selective REM sleep deprivation improves expectation-related placebo analgesia. PLoS One [Electron Resour] 10(12):e0144992

    Google Scholar 

  • Chouchou F, Dang-Vu TT, Rainville P, Lavigne G (2018) The role of sleep in learning placebo effects. Int Rev Neurobiol 139:321–355

    PubMed  Google Scholar 

  • Danilov A, Kurganova J (2016) Melatonin in chronic pain syndromes. Pain Ther 5(1):1–17

    PubMed Central  PubMed  Google Scholar 

  • de Oliveira DL, Hirotsu C, Tufik S, Andersen ML (2017) The interfaces between vitamin D, sleep and pain. J Endocrinol 234(1):R23–R36

    PubMed  Google Scholar 

  • Dinges DF, Pack F, Williams K et al (1997) Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4–5 hours per night. Sleep 20(4):267–277

    CAS  PubMed  Google Scholar 

  • Dinh ST, Nickel MM, Tiemann L et al (2019) Brain dysfunction in chronic pain patients assessed by resting-state electroencephalography. Pain 1:595470

    Google Scholar 

  • Dubrovsky B, Janal MN, Lavigne GJ et al (2017) Depressive symptoms account for differences between self-reported versus polysomnographic assessment of sleep quality in women with myofascial TMD. J Oral Rehabil 44(12):925–933

    CAS  PubMed Central  PubMed  Google Scholar 

  • Duenas M, Ojeda B, Salazar A, Mico JA, Failde I (2016) A review of chronic pain impact on patients, their social environment and the health care system. J Pain Res 9:457–467

    PubMed Central  PubMed  Google Scholar 

  • Dunietz GL, Swanson LM, Jansen EC et al (2018) Key insomnia symptoms and incident pain in older adults: direct and mediated pathways through depression and anxiety. Sleep 41(9):309

    Google Scholar 

  • Edwards RR (2005) Individual differences in endogenous pain modulation as a risk factor for chronic pain. Neurology 65(3):437–443

    PubMed  Google Scholar 

  • Edwards RR, Grace E, Peterson S, Klick B, Haythornthwaite JA, Smith MT (2009) Sleep continuity and architecture: associations with pain-inhibitory processes in patients with temporomandibular joint disorder. Eur J Pain 13(10):1043–1047

    CAS  PubMed Central  PubMed  Google Scholar 

  • Eichhorn N, Treede RD, Schuh-Hofer S (2018) The role of sex in sleep deprivation related changes of nociception and conditioned pain modulation. Neuroscience 387:191–200

    CAS  PubMed  Google Scholar 

  • Evans S, Djilas V, Seidman LC, Zeltzer LK, Tsao JCI (2017) Sleep quality, affect, pain, and disability in children with chronic pain: is affect a mediator or moderator? J Pain 18(9):1087–1095

    PubMed Central  PubMed  Google Scholar 

  • Everson CA (1993) Sustained sleep deprivation impairs host defense. Am J Physiol 265(5 Pt 2):R1148–R1154

    CAS  PubMed  Google Scholar 

  • Faraut B, Leger D, Medkour T et al (2015) Napping reverses increased pain sensitivity due to sleep restriction. PLoS One [Electron Resour] 10(2):e0117425

    Google Scholar 

  • Fatima Y, Doi SA, Mamun AA (2016) Sleep quality and obesity in young subjects: a meta-analysis. Obes Rev 17(11):1154–1166

    CAS  PubMed  Google Scholar 

  • Finan PH, Garland EL (2015) The role of positive affect in pain and its treatment. Clin J Pain 31(2):177–187

    PubMed Central  PubMed  Google Scholar 

  • Finan PH, Remeniuk B (2016) Is the brain reward system a mechanism of the association of sleep and pain? Pain Manag 6(1):5–8

    PubMed  Google Scholar 

  • Finan PH, Goodin BR, Smith MT (2013) The association of sleep and pain: an update and a path forward. J Pain 14(12):1539–1552

    PubMed Central  PubMed  Google Scholar 

  • Finan PH, Buenaver LF, Coryell VT, Smith MT (2014) Cognitive-behavioral therapy for comorbid insomnia and chronic pain. Sleep Med Clin 9(2):261–274

    PubMed Central  PubMed  Google Scholar 

  • Finan PH, Quartana PJ, Remeniuk B et al (2017) Partial sleep deprivation attenuates the positive affective system: effects across multiple measurement modalities. Sleep 40(1):zsw017

    Google Scholar 

  • Fisher K, Laikin AM, Sharp KMH, Criddle CA, Palermo TM, Karlson CW (2018) Temporal relationship between daily pain and actigraphy sleep patterns in pediatric sickle cell disease. J Behav Med 41(3):416–422

    PubMed  Google Scholar 

  • Frase L, Selhausen P, Krone L et al (2019) Differential effects of bifrontal tDCS on arousal and sleep duration in insomnia patients and healthy controls. Brain Stimul 12(3):674–683

    PubMed  Google Scholar 

  • Gangwisch JE, Heymsfield SB, Boden-Albala B et al (2007) Sleep duration as a risk factor for diabetes incidence in a large US sample. Sleep 30(12):1667–1673

    PubMed Central  PubMed  Google Scholar 

  • Gaskin DJ, Richard P (2012) The economic costs of pain in the United States. J Pain 13(8):715–724

    PubMed  Google Scholar 

  • Generaal E, Vogelzangs N, Penninx BW, Dekker J (2017) Insomnia, sleep duration, depressive symptoms, and the onset of chronic multisite musculoskeletal pain. Sleep 40(1):zsw030

    Google Scholar 

  • Gonzalez-Ortiz M, Martinez-Abundis E, Balcazar-Munoz BR, Pascoe-Gonzalez S (2000) Effect of sleep deprivation on insulin sensitivity and cortisol concentration in healthy subjects. Diabetes Nutr Metab 13(2):80–83

    CAS  PubMed  Google Scholar 

  • Goodin BR, Smith MT, Quinn NB, King CD, McGuire L (2012) Poor sleep quality and exaggerated salivary cortisol reactivity to the cold pressor task predict greater acute pain severity in a non-clinical sample. Biol Psychol 91(1):36–41

    PubMed Central  PubMed  Google Scholar 

  • Gotter AL, Webber AL, Coleman PJ, Renger JJ, Winrow CJ (2012) International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology. Pharmacol Rev 64(3):389–420

    CAS  PubMed  Google Scholar 

  • Grill JD, Coghill RC (2002) Transient analgesia evoked by noxious stimulus offset. J Neurophysiol 87(4):2205–2208

    PubMed  Google Scholar 

  • Haack M, Scott-Sutherland J, Santangelo G, Simpson NS, Sethna N, Mullington JM (2012) Pain sensitivity and modulation in primary insomnia. Eur J Pain 16(4):522–533

    CAS  PubMed Central  PubMed  Google Scholar 

  • Haack M, Simpson N, Sethna N, Kaur S, Mullington J (2019) Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications. Neuropsychopharmacology. https://doi.org/10.1038/s41386-019-0439-z

    Article  PubMed  PubMed Central  Google Scholar 

  • Herrero Babiloni A, Guay S, Nixdorf DR, de Beaumont L, Lavigne G (2018a) Non-invasive brain stimulation in chronic orofacial pain: a systematic review. J Pain Res 11:1445–1457

    PubMed Central  PubMed  Google Scholar 

  • Herrero Babiloni A, De Beaumont L, Lavigne GJ (2018b) Transcranial magnetic stimulation: potential use in obstructive sleep apnea and sleep bruxism. Sleep Med Clin 13(4):571–582

    CAS  PubMed  Google Scholar 

  • Herrero JF, Laird JM, Lopez-Garcia JA (2000) Wind-up of spinal cord neurones and pain sensation: much ado about something? Prog Neurobiol 61(2):169–203

    CAS  PubMed  Google Scholar 

  • Hillman DR, Lack LC (2013) Public health implications of sleep loss: the community burden. Med J Aust 199(8):S7–10

    PubMed  Google Scholar 

  • Hillman D, Mitchell S, Streatfeild J, Burns C, Bruck D, Pezzullo L (2018) The economic cost of inadequate sleep. Sleep 41(8):zsy083

    Google Scholar 

  • Holick MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80(6 Suppl):1678S–1688S

    CAS  PubMed  Google Scholar 

  • Hong S, Mills PJ, Loredo JS, Adler KA, Dimsdale JE (2005) The association between interleukin-6, sleep, and demographic characteristics. Brain Behav Immun 19(2):165–172

    CAS  PubMed  Google Scholar 

  • Huang CT, Chiang RP, Chen CL, Tsai YJ (2014) Sleep deprivation aggravates median nerve injury-induced neuropathic pain and enhances microglial activation by suppressing melatonin secretion. Sleep 37(9):1513–1523

    PubMed Central  PubMed  Google Scholar 

  • Huang Z, Li Y, Bianchi MT et al (2018) Repetitive transcranial magnetic stimulation of the right parietal cortex for comorbid generalized anxiety disorder and insomnia: a randomized, double-blind, sham-controlled pilot study. Brain Stimul 11(5):1103–1109

    PubMed  Google Scholar 

  • International Pain Summit of the International Association for the Study of P (2011) Declaration of Montreal: declaration that access to pain management is a fundamental human right. J Pain Palliat Care Pharmacother 25(1):29–31

    Google Scholar 

  • Irwin MR, Olmstead R, Carroll JE (2016) Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry 80(1):40–52

    PubMed  Google Scholar 

  • Janssen SA (2002) Negative affect and sensitization to pain. Scand J Psychol 43(2):131–137

    PubMed  Google Scholar 

  • Jodoin M, Rouleau D, Larson-Dupuis C, Gosselin N, De Beaumont L (2017) The clinical utility of repetitive transcranial magnetic stimulation in reducing the risks of transitioning from acute to chronic pain in traumatically injured patients. Prog Neuropsychopharmacol Biol Psychiatry. 87(Pt B):322–331. https://doi.org/10.1016/j.pnpbp.2017.07.005

    Article  PubMed  Google Scholar 

  • Karmann AJ, Lauer C, Ziegler E, Killian L, Horn-Hofmann C, Lautenbacher S (2018) Associations of nocturnal sleep with experimental pain and pain catastrophizing in healthy volunteers. Biol Psychol 135:1–7

    PubMed  Google Scholar 

  • Kaur T, Shyu BC (2018) Melatonin: a new-generation therapy for reducing chronic pain and improving sleep disorder-related pain. Adv Exp Med Biol 1099:229–251

    CAS  PubMed  Google Scholar 

  • Kichline T, Cushing CC, Ortega A, Friesen C, Schurman JV (2019) Associations between physical activity and chronic pain severity in youth with chronic abdominal pain. Clin J Pain 35:618–624

    PubMed  Google Scholar 

  • Killgore WD, Balkin TJ, Wesensten NJ (2006) Impaired decision making following 49 h of sleep deprivation. J Sleep Res 15(1):7–13

    PubMed  Google Scholar 

  • Klyne DM, Moseley GL, Sterling M, Barbe MF, Hodges PW (2018) Individual variation in pain sensitivity and conditioned pain modulation in acute low back pain: effect of stimulus type, sleep, and psychological and lifestyle factors. J Pain 19(8):942 e941–942 e918

    Google Scholar 

  • Knutson KL, Spiegel K, Penev P, Van Cauter E (2007) The metabolic consequences of sleep deprivation. Sleep Med Rev 11(3):163–178

    PubMed Central  PubMed  Google Scholar 

  • Koffel EA, Koffel JB, Gehrman PR (2015) A meta-analysis of group cognitive behavioral therapy for insomnia. Sleep Med Rev 19:6–16

    PubMed  Google Scholar 

  • Konjarski M, Murray G, Lee VV, Jackson ML (2018) Reciprocal relationships between daily sleep and mood: a systematic review of naturalistic prospective studies. Sleep Med Rev 42:47–58

    PubMed  Google Scholar 

  • Kothari DJ, Davis MC, Yeung EW, Tennen HA (2015) Positive affect and pain: mediators of the within-day relation linking sleep quality to activity interference in fibromyalgia. Pain 156(3):540–546

    PubMed Central  PubMed  Google Scholar 

  • Krause AJ, Prather AA, Wager TD, Lindquist MA, Walker MP (2019) The pain of sleep loss: a brain characterization in humans. J Neurosci 39(12):2291–2300

    CAS  PubMed Central  PubMed  Google Scholar 

  • Landry GJ, Best JR, Liu-Ambrose T (2015) Measuring sleep quality in older adults: a comparison using subjective and objective methods. Front Aging Neurosci 7:166

    PubMed Central  PubMed  Google Scholar 

  • Larsen JT, Hershfield HE, Stastny BJ, Hester N (2017) On the relationship between positive and negative affect: their correlation and their co-occurrence. Emotion 17(2):323–336

    PubMed  Google Scholar 

  • Lautenbacher S (2018) Sleep and pain are definitely coupled-but how tight is this coupling? Pain 159(1):3–4

    PubMed  Google Scholar 

  • Lautenbacher S, Kundermann B, Krieg JC (2006) Sleep deprivation and pain perception. Sleep Med Rev 10(5):357–369

    PubMed  Google Scholar 

  • Laverdure-Dupont D, Rainville P, Renancio C, Montplaisir J, Lavigne G (2018) Placebo analgesia persists during sleep: an experimental study. Prog Neuropsychopharmacol Biol Psychiatry 85:33–38

    PubMed  Google Scholar 

  • Lavigne GJ, Sessle BJ (2016) The neurobiology of orofacial pain and sleep and their interactions. J Dent Res 95:1109–1116

    CAS  PubMed  Google Scholar 

  • Lavigne G, Zucconi M, Castronovo C, Manzini C, Marchettini P, Smirne S (2000) Sleep arousal response to experimental thermal stimulation during sleep in human subjects free of pain and sleep problems. Pain 84(2–3):283–290

    CAS  PubMed  Google Scholar 

  • Lee MA, Walker RW, Hildreth TJ, Prentice WM (2006) A survey of pain in idiopathic Parkinson’s disease. J Pain Symptom Manag 32(5):462–469

    Google Scholar 

  • Lee YC, Lu B, Edwards RR et al (2013) The role of sleep problems in central pain processing in rheumatoid arthritis. Arthritis Rheum 65(1):59–68

    PubMed Central  PubMed  Google Scholar 

  • Lewandowski Holley A, Rabbitts J, Zhou C, Durkin L, Palermo TM (2017) Temporal daily associations among sleep and pain in treatment-seeking youth with acute musculoskeletal pain. J Behav Med 40(4):675–681

    PubMed  Google Scholar 

  • Lewis GN, Rice DA, McNair PJ (2012) Conditioned pain modulation in populations with chronic pain: a systematic review and meta-analysis. J Pain 13(10):936–944

    PubMed  Google Scholar 

  • Ligato D, Petersen KK, Morch CD, Arendt-Nielsen L (2018) Offset analgesia: the role of peripheral and central mechanisms. Eur J Pain 22(1):142–149

    CAS  PubMed  Google Scholar 

  • Liguori C, Izzi F, Mercuri NB et al (2017) Vitamin D status of male OSAS patients improved after long-term CPAP treatment mainly in obese subjects. Sleep Med 29:81–85

    PubMed  Google Scholar 

  • Liu JW, Tu YK, Lai YF et al (2019) Associations between sleep disturbances and suicidal ideation, plans, and attempts in adolescents: a systematic review and meta-analysis. Sleep 42:zsz054

    PubMed  Google Scholar 

  • Lotsch J, Ultsch A (2018) Machine learning in pain research. Pain 159(4):623–630

    PubMed  Google Scholar 

  • Marshansky S, Mayer P, Rizzo D, Baltzan M, Denis R, Lavigne GJ (2018) Sleep, chronic pain, and opioid risk for apnea. Prog Neuropsychopharmacol Biol Psychiatry 87(Pt B):234–244

    CAS  PubMed  Google Scholar 

  • Mathias JL, Cant ML, Burke ALJ (2018) Sleep disturbances and sleep disorders in adults living with chronic pain: a meta-analysis. Sleep Med 52:198–210

    CAS  PubMed  Google Scholar 

  • Matre D, Andersen MR, Knardahl S, Nilsen KB (2016) Conditioned pain modulation is not decreased after partial sleep restriction. Eur J Pain 20(3):408–416

    CAS  PubMed  Google Scholar 

  • Mazza S, Magnin M, Bastuji H (2012) Pain and sleep: from reaction to action. Neurophysiol Clin 42(5):337–344

    CAS  PubMed  Google Scholar 

  • McCrae CS, Williams J, Roditi D et al (2018) Cognitive behavioral treatments for insomnia (CBT-I) and pain (CBT-P) in adults with comorbid chronic insomnia and fibromyalgia: clinical outcomes from the SPIN randomized controlled trial. Sleep 14:1595–1603

    Google Scholar 

  • Melzack R (1990) Phantom limbs and the concept of a neuromatrix. Trends Neurosci 13(3):88–92

    CAS  PubMed  Google Scholar 

  • Moana-Filho EJ, Herrero Babiloni A (2018) Endogenous pain modulation in chronic temporomandibular disorders: Derivation of pain modulation profiles and assessment of its relationship with clinical characteristics. J Oral Rehabil 46(3):219–232. https://doi.org/10.1111/joor.12745

    Article  PubMed  Google Scholar 

  • Moana-Filho EJ, Herrero Babiloni A, Theis-Mahon NR (2018) Endogenous pain modulation in chronic orofacial pain: a systematic review and meta-analysis. Pain 159(8):1441–1455

    PubMed  Google Scholar 

  • Moana-Filho EJ, Herrero Babiloni A, Nisley A (2019) Endogenous pain modulation assessed with offset analgesia is not impaired in chronic temporomandibular disorder pain patients. J Oral Rehabil. https://doi.org/10.1111/joor.12832

    Article  PubMed  Google Scholar 

  • Moradi M, Yazdanian M, Haghparast A (2015) Role of dopamine D2-like receptors within the ventral tegmental area and nucleus accumbens in antinociception induced by lateral hypothalamus stimulation. Behav Brain Res 292:508–514

    CAS  PubMed  Google Scholar 

  • Mullington JM, Simpson NS, Meier-Ewert HK, Haack M (2010) Sleep loss and inflammation. Best Pract Res Clin Endocrinol Metab 24(5):775–784

    CAS  PubMed Central  PubMed  Google Scholar 

  • Ng KY, Leong MK, Liang H, Paxinos G (2017) Melatonin receptors: distribution in mammalian brain and their respective putative functions. Brain Struct Funct 222(7):2921–2939

    CAS  PubMed  Google Scholar 

  • Niesters M, Hoitsma E, Sarton E, Aarts L, Dahan A (2011) Offset analgesia in neuropathic pain patients and effect of treatment with morphine and ketamine. Anesthesiology 115(5):1063–1071

    CAS  PubMed  Google Scholar 

  • Nir RR, Yarnitsky D (2015) Conditioned pain modulation. Curr Opin Support Palliat Care 9(2):131–137

    PubMed  Google Scholar 

  • O’Brien AT, Deitos A, Trinanes Pego Y, Fregni F, Carrillo-de-la-Pena MT (2018) Defective endogenous pain modulation in fibromyalgia: a meta-analysis of temporal summation and conditioned pain modulation paradigms. J Pain 19(8):819–836

    PubMed  Google Scholar 

  • O’Connell NE, Marston L, Spencer S, DeSouza LH, Wand BM (2018) Non-invasive brain stimulation techniques for chronic pain. Cochrane Database Syst Rev 3:CD008208

    PubMed  Google Scholar 

  • Ogilvie RD (2001) The process of falling asleep. Sleep Med Rev 5(3):247–270

    PubMed  Google Scholar 

  • Parrino L, Boselli M, Spaggiari MC, Smerieri A, Terzano MG (1998) Cyclic alternating pattern (CAP) in normal sleep: polysomnographic parameters in different age groups. Electroencephalogr Clin Neurophysiol 107(6):439–450

    CAS  PubMed  Google Scholar 

  • Parrino L, Ferri R, Bruni O, Terzano MG (2012) Cyclic alternating pattern (CAP): the marker of sleep instability. Sleep Med Rev 16(1):27–45

    PubMed  Google Scholar 

  • Parrino L, Grassi A, Milioli G (2014) Cyclic alternating pattern in polysomnography: what is it and what does it mean? Curr Opin Pulm Med 20(6):533–541

    PubMed  Google Scholar 

  • Paul-Savoie E, Marchand S, Morin M et al (2012) Is the deficit in pain inhibition in fibromyalgia influenced by sleep impairments? Open Rheumatol J 6:296–302

    PubMed Central  PubMed  Google Scholar 

  • Peter-Derex L, Magnin M, Bastuji H (2015) Heterogeneity of arousals in human sleep: a stereo-electroencephalographic study. Neuroimage 123:229–244

    PubMed  Google Scholar 

  • Pigeon WR, Pinquart M, Conner K (2012) Meta-analysis of sleep disturbance and suicidal thoughts and behaviors. J Clin Psychiatry 73(9):e1160–e1167

    PubMed  Google Scholar 

  • Price DD (2000) Psychological and neural mechanisms of the affective dimension of pain. Science 288(5472):1769–1772

    CAS  PubMed  Google Scholar 

  • Price DD, Hu JW, Dubner R, Gracely RH (1977) Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses. Pain 3(1):57–68

    CAS  PubMed  Google Scholar 

  • Quartana PJ, Campbell CM, Edwards RR (2009) Pain catastrophizing: a critical review. Expert Rev Neurother 9(5):745–758

    PubMed Central  PubMed  Google Scholar 

  • Rabbitts JA, Zhou C, Narayanan A, Palermo TM (2017) Longitudinal and temporal associations between daily pain and sleep patterns after major pediatric surgery. J Pain 18(6):656–663

    PubMed Central  PubMed  Google Scholar 

  • Racine M (2018) Chronic pain and suicide risk: a comprehensive review. Prog Neuropsychopharmacol Biol Psychiatry 87(Pt B):269–280

    PubMed  Google Scholar 

  • Ravyts SG, Dzierzewski JM, Raldiris T, Perez E (2018) Sleep and pain interference in individuals with chronic pain in mid- to late-life: the influence of negative and positive affect. J Sleep Res 1:e12807

    Google Scholar 

  • Razavi BM, Hosseinzadeh H (2017) A review of the role of orexin system in pain modulation. Biomed Pharmacother 90:187–193

    CAS  PubMed  Google Scholar 

  • Redwine L, Hauger RL, Gillin JC, Irwin M (2000) Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. J Clin Endocrinol Metab 85(10):3597–3603

    CAS  PubMed  Google Scholar 

  • Ree A, Nilsen KB, Knardahl S, Sand T, Matre D (2019) Sleep restriction does not potentiate nocebo-induced changes in pain and cortical potentials. Eur J Pain. https://doi.org/10.1002/ejp.1466

    Article  PubMed  Google Scholar 

  • Rizzi M, Sarzi-Puttini P, Atzeni F et al (2004) Cyclic alternating pattern: a new marker of sleep alteration in patients with fibromyalgia? J Rheumatol 31(6):1193–1199

    PubMed  Google Scholar 

  • Rizzi M, Radovanovic D, Santus P et al (2017) Influence of autonomic nervous system dysfunction in the genesis of sleep disorders in fibromyalgia patients. Clin Exp Rheumatol 35 Suppl 105(3):74–80

    PubMed  Google Scholar 

  • Roohbakhsh A, Alavi MS, Azhdari-Zarmehri H (2018) The orexinergic (hypocretin) system and nociception: an update to supraspinal mechanisms. Curr Med Chem 25(32):3917–3929

    CAS  PubMed  Google Scholar 

  • Salas RE, Galea JM, Gamaldo AA et al (2014) Increased use-dependent plasticity in chronic insomnia. Sleep 37(3):535–544

    PubMed Central  PubMed  Google Scholar 

  • Sardi NF, Lazzarim MK, Guilhen VA et al (2018a) Chronic sleep restriction increases pain sensitivity over time in a periaqueductal gray and nucleus accumbens dependent manner. Neuropharmacology 139:52–60

    CAS  PubMed  Google Scholar 

  • Sardi NF, Tobaldini G, Morais RN, Fischer L (2018b) Nucleus accumbens mediates the pronociceptive effect of sleep deprivation: the role of adenosine A2A and dopamine D2 receptors. Pain 159(1):75–84

    CAS  PubMed  Google Scholar 

  • Sauvet F, Leftheriotis G, Gomez-Merino D et al (2010) Effect of acute sleep deprivation on vascular function in healthy subjects. J Appl Physiol 108(1):68–75

    PubMed  Google Scholar 

  • Schuh-Hofer S, Wodarski R, Pfau DB et al (2013) One night of total sleep deprivation promotes a state of generalized hyperalgesia: a surrogate pain model to study the relationship of insomnia and pain. Pain 154(9):1613–1621

    PubMed  Google Scholar 

  • Schuh-Hofer S, Baumgartner U, Treede RD (2015) Effect of sleep deprivation on the electrophysiological signature of habituation to noxious laser stimuli. Eur J Pain 19(8):1197–1209

    CAS  PubMed  Google Scholar 

  • Schuh-Hofer S, Eichhorn N, Grinevich V, Treede RD (2018) Sleep deprivation related changes of plasma oxytocin in males and female contraceptive users depend on sex and correlate differentially with anxiety and pain hypersensitivity. Front Behav Neurosci 12:161

    PubMed Central  PubMed  Google Scholar 

  • Schwartz N, Temkin P, Jurado S et al (2014) Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens. Science 345(6196):535–542

    CAS  PubMed Central  PubMed  Google Scholar 

  • Seminowicz DA, Remeniuk B, Krimmel SR et al (2019) Pain-related nucleus accumbens function: modulation by reward and sleep disruption. Pain 160(5):1196–1207

    CAS  PubMed  PubMed Central  Google Scholar 

  • Shahin M, Ahmed B, Hamida ST, Mulaffer FL, Glos M, Penzel T (2017) Deep learning and insomnia: assisting clinicians with their diagnosis. IEEE J Biomed Health Inform 21(6):1546–1553

    PubMed  Google Scholar 

  • Shi L, Chen SJ, Ma MY et al (2018) Sleep disturbances increase the risk of dementia: a systematic review and meta-analysis. Sleep Med Rev 40:4–16

    PubMed  Google Scholar 

  • Shipton EA, Shipton EE (2015) Vitamin D and pain: vitamin D and its role in the aetiology and maintenance of chronic pain states and associated comorbidities. Pain Res Treat 2015:904967

    PubMed Central  PubMed  Google Scholar 

  • Siegel JM (2005) Clues to the functions of mammalian sleep. Nature 437(7063):1264–1271

    CAS  PubMed  PubMed Central  Google Scholar 

  • Siegel JM (2011) REM sleep: a biological and psychological paradox. Sleep Med Rev 15(3):139–142

    PubMed Central  PubMed  Google Scholar 

  • Simpson N, Dinges DF (2007) Sleep and inflammation. Nutr Rev 65(12 Pt 2):S244–S252

    PubMed  Google Scholar 

  • Simpson NS, Scott-Sutherland J, Gautam S, Sethna N, Haack M (2018) Chronic exposure to insufficient sleep alters processes of pain habituation and sensitization. Pain 159(1):33–40

    PubMed Central  PubMed  Google Scholar 

  • Smith BW, Zautra AJ (2008) Vulnerability and resilience in women with arthritis: test of a two-factor model. J Consult Clin Psychol 76(5):799–810

    PubMed  Google Scholar 

  • Smith MT, Edwards RR, McCann UD, Haythornthwaite JA (2007) The effects of sleep deprivation on pain inhibition and spontaneous pain in women. Sleep 30(4):494–505

    PubMed  Google Scholar 

  • Smith MT Jr, Remeniuk B, Finan PH et al (2019) Sex differences in measures of central sensitization and pain sensitivity to experimental sleep disruption: implications for sex differences in chronic pain. Sleep 42(2):zsy209

    Google Scholar 

  • Staud R (2012) Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions. Expert Rev Neurother 12(5):577–585

    PubMed Central  PubMed  Google Scholar 

  • Taylor AM, Becker S, Schweinhardt P, Cahill C (2016) Mesolimbic dopamine signaling in acute and chronic pain: implications for motivation, analgesia, and addiction. Pain 157(6):1194–1198

    PubMed Central  PubMed  Google Scholar 

  • Tiede W, Magerl W, Baumgartner U, Durrer B, Ehlert U, Treede RD (2010) Sleep restriction attenuates amplitudes and attentional modulation of pain-related evoked potentials, but augments pain ratings in healthy volunteers. Pain 148(1):36–42

    PubMed  Google Scholar 

  • Treede RD (2018) The International Association for the Study of Pain definition of pain: as valid in 2018 as in 1979, but in need of regularly updated footnotes. Pain Rep 3(2):e643

    PubMed Central  PubMed  Google Scholar 

  • Treede RD, Rief W, Barke A et al (2015) A classification of chronic pain for ICD-11. Pain 156(6):1003–1007

    PubMed Central  PubMed  Google Scholar 

  • Treede RD, Rief W, Barke A et al (2019) Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). Pain 160(1):19–27

    PubMed  Google Scholar 

  • Turk DC, Fillingim RB, Ohrbach R, Patel KV (2016) Assessment of psychosocial and functional impact of chronic pain. J Pain 17(9 Suppl):T21–T49

    PubMed  Google Scholar 

  • Valeriani M (2015) Increased habituation to painful stimuli: a self-protective mechanism during prolonged wakefulness? Eur J Pain 19(8):1055–1056

    CAS  PubMed  Google Scholar 

  • Valrie CR, Bromberg MH, Palermo T, Schanberg LE (2013) A systematic review of sleep in pediatric pain populations. J Dev Behav Pediatr JDBP 34(2):120–128

    PubMed  Google Scholar 

  • Valrie CR, Kilpatrick RL, Alston K et al (2019) Investigating the sleep-pain relationship in youth with sickle cell utilizing mHealth technology. J Pediatr Psychol 44(3):323–332

    PubMed Central  PubMed  Google Scholar 

  • Venner A, Todd WD, Fraigne J et al (2019) Newly identified sleep-wake and circadian circuits as potential therapeutic targets. Sleep 42(5):zsz023

    PubMed Central  PubMed  Google Scholar 

  • Vgontzas AN, Papanicolaou DA, Bixler EO et al (1999) Circadian interleukin-6 secretion and quantity and depth of sleep. J Clin Endocrinol Metab 84(8):2603–2607

    CAS  PubMed  Google Scholar 

  • Volkow ND, Tomasi D, Wang GJ et al (2012) Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain. J Neurosci 32(19):6711–6717

    CAS  PubMed Central  PubMed  Google Scholar 

  • von Kanel R, Muller-Hartmannsgruber V, Kokinogenis G, Egloff N (2014) Vitamin D and central hypersensitivity in patients with chronic pain. Pain Med 15(9):1609–1618

    Google Scholar 

  • Walker MP, Stickgold R (2006) Sleep, memory, and plasticity. Annu Rev Psychol 57:139–166

    PubMed  Google Scholar 

  • Watkins LR, Milligan ED, Maier SF (2003) Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol 521:1–21

    CAS  PubMed  Google Scholar 

  • Web statement on pain management guidance (2019) https://www.who.int/medicines/areas/quality_safety/guide_on_pain/en/. Accessed 24 Aug 2019

  • Whibley D, AlKandari N, Kristensen K et al (2019) Sleep and pain: a systematic review of studies of mediation. Clin J Pain 20:S19–S20

    Google Scholar 

  • Wiech K, Tracey I (2009) The influence of negative emotions on pain: behavioral effects and neural mechanisms. Neuroimage 47(3):987–994

    PubMed  Google Scholar 

  • Williams AC, Craig KD (2016) Updating the definition of pain. Pain 157(11):2420–2423

    PubMed  Google Scholar 

  • Wilt JA, Davin S, Scheman J (2016) A multilevel path model analysis of the relations between sleep, pain, and pain catastrophizing in chronic pain rehabilitation patients. Scand J Pain 10:122–129

    PubMed  Google Scholar 

  • Wood PB, Patterson JC 2nd, Sunderland JJ, Tainter KH, Glabus MF, Lilien DL (2007) Reduced presynaptic dopamine activity in fibromyalgia syndrome demonstrated with positron emission tomography: a pilot study. J Pain 8(1):51–58

    CAS  PubMed  Google Scholar 

  • Woolf CJ (2010) What is this thing called pain? J Clin Investig 120(11):3742–3744

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wu YL, Chang LY, Lee HC, Fang SC, Tsai PS (2017) Sleep disturbances in fibromyalgia: a meta-analysis of case–control studies. J Psychosom Res 96:89–97

    PubMed  Google Scholar 

  • Wu Z, Malihi Z, Stewart AW, Lawes CM, Scragg R (2018) The association between vitamin D concentration and pain: a systematic review and meta-analysis. Public Health Nutr 21(11):2022–2037

    PubMed  Google Scholar 

  • Yarnitsky D (2015) Role of endogenous pain modulation in chronic pain mechanisms and treatment. Pain 156(Suppl 1):S24–S31

    PubMed  Google Scholar 

  • Yarnitsky D, Granot M, Granovsky Y (2014) Pain modulation profile and pain therapy: between pro- and antinociception. Pain 155(4):663–665

    PubMed  Google Scholar 

  • Yin J, Jin X, Shan Z et al (2017) Relationship of sleep duration with all-cause mortality and cardiovascular events: a systematic review and dose–response meta-analysis of prospective cohort studies. J Am Heart Assoc 6(9):e005947

    PubMed Central  PubMed  Google Scholar 

  • Zhai L, Zhang H, Zhang D (2015) Sleep duration and depression among adults: a meta-analysis of prospective studies. Depress Anxiety 32(9):664–670

    PubMed  Google Scholar 

  • Zhang JM, An J (2007) Cytokines, inflammation, and pain. Int Anesthesiol Clin 45(2):27–37

    CAS  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Research Center, Hôpital Du Sacré-Coeur de Montréal, CIUSSS Du Nord-de-l’Île-de-Montréal, Université De Montréal, Montreal, Canada

    Alberto Herrero Babiloni, Beatrice P. De Koninck, Gabrielle Beetz, Louis De Beaumont & Gilles J. Lavigne

  2. Faculté de Médecine Dentaire, Université de Montréal, Montreal, Canada

    Alberto Herrero Babiloni & Gilles J. Lavigne

  3. Experimental Medicine Division, McGill University, Montreal, Canada

    Alberto Herrero Babiloni, Marc O. Martel & Gilles J. Lavigne

  4. Department of Dentistry and Anesthesia, McGill University, Montreal, Canada

    Marc O. Martel

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  1. Alberto Herrero Babiloni
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  2. Beatrice P. De Koninck
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Herrero Babiloni, A., De Koninck, B.P., Beetz, G. et al. Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship. J Neural Transm 127, 647–660 (2020). https://doi.org/10.1007/s00702-019-02067-z

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