Abstract
Fluctuating body weight is a commonly reported nonmotor feature in patients with Parkinson’s disease (PD). We hypothesised that striatal dopamine transporter (DAT) density at the time of diagnosis might play an important role in weight regulation in patients with PD. DAT density was measured from 123I-FP-CIT single-photon emission computed tomography. Region-of-interest analyses were performed to measure the specific binding of 123I-FP-CIT to DAT, and the putamen-to-caudate nucleus ratio (PCR) was calculated. Body weight was measured at baseline (W0) and at 48 months (W48). We classified subjects into three groups: weight loss, stable, and weight gain. In final analyses, 163 patients (106 men, 57 women) were included. PCR significantly differed by group in men, but not in women or across all patients. In men, PCR was slightly negatively associated with the percentage change in weight. No such correlation was found across all patients or in women. In univariate and multivariate logistic regression analyses, low PCR was associated with future weight gain in men with PD but not in women. In conclusion, striatal DAT availability at the time of diagnosis could predict subsequent weight change in men with PD.
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03 May 2023
A Correction to this paper has been published: https://doi.org/10.1007/s00702-023-02637-2
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Acknowledgements
PPMI, a public–private partnership, is funded by the Michael J. Fox Foundation for Parkinson’s Research and funding partners, including AbbVie, Avid, Biogen, Bristol-Myers Squibb, COVANCE, GE Healthcare, Genentech, GlaxoSmithKline, Lundbeck, Lilly, Merck, Meso Scale Discovery, Pfizer, Piramal, Roche, Sanofi Genzyme, Servier, TEVA, and UCB. This work was supported by a 2-Year Research Grant of Pusan National University.
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Kyoungjune Pak, Heeyoung Kim and Youngduk Seo contributed equally as first authors. Kyoungjune Pak and Myung Jun Lee contributed equally as corresponding authors.
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Pak, K., Kim, H., Seok, J.W. et al. Prediction of future weight change with dopamine transporter in patients with Parkinson’s disease. J Neural Transm 126, 723–729 (2019). https://doi.org/10.1007/s00702-019-02016-w
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DOI: https://doi.org/10.1007/s00702-019-02016-w