Abstract
We examined the correlations between cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) and imaging assessment scores, using 123I-Ioflupane SPECT and 123I-MIBG myocardial scintigraphy in 23 drug naïve PD patients. The CSF 5-HIAA concentration correlated with the H/M ratio of the delayed image (r = 0.458, p < 0.05) and the washout rate (r = − 0.642, p < 0.01) of 123I-MIBG myocardial scintigraphy. These correlations suggest some unclarified pathophysiological links between the central serotonergic and cardiac sympathetic systems.
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Funding
This study was partly supported by a scholarship donation from Nippon Boehringer Ingelheim Co., Ltd., Pfizer Japan Inc., Astellas Pharma Inc., Shionogi & Co., Ltd., FP Pharmaceutical Corporation, MSD K.K. and Takeda Pharmaceutical Co., Ltd. These funders played no role for this study.
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The Ethics Committee of Showa University School of Medicine approved this study, and it was performed in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants.
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Murakami, H., Yamamoto, K., Yasumoto, T. et al. Cerebrospinal fluid 5-HIAA concentrations correlate with cardiac uptake of 123I-MIBG during myocardial scintigraphy in drug naïve Parkinson’s disease. J Neural Transm 125, 1511–1514 (2018). https://doi.org/10.1007/s00702-018-1917-x
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DOI: https://doi.org/10.1007/s00702-018-1917-x