Journal of Neural Transmission

, Volume 125, Issue 5, pp 875–881 | Cite as

Interleukin 6 and complement serum level study in Parkinson’s disease

  • Branislav Veselý
  • Michal Dufek
  • Vojtech Thon
  • Miroslav Brozman
  • Silvia Királová
  • Tatiana Halászová
  • Eva Koriťáková
  • Ivan Rektor
Neurology and Preclinical Neurological Studies - Original Article


The objective of this study is to assess whether elevation of serum inflammatory markers levels may indicate the progression of clinical impairment in Parkinson’s disease (PD) patients. In 47 PD patients, the serum levels of the C3 and C4 part of the complement and Interleukin-6 (IL-6) were measured. The results at baseline and after 2 years were correlated with scales measuring memory, depression, motor symptoms, and quality of life. Patients with higher levels of C3 and C4 at baseline had decreased quality of life, verbal ability, and memory. Patients with higher IL-6 at baseline showed worse depression scores at 2 years. Patients with persistently higher levels of C3 and C4 at 2 years had worse quality of life and memory ability. Uncorrected p values are reported due to the exploratory nature of the study. The results indicate an impact of inflammation on non-motor signs and quality of life in PD. The increase of levels of serum inflammatory biomarkers may indicate the progression of non-motor impairment in PD.


Complement Interleukin 6 Parkinson’s disease 



Addenbrooke’s cognitive examination


Activity of Daily Living Scale


Barthel Index


Benton visual retention test


Clock drawing test


Cerebrospinal fluid


Electrochemiluminescence immunoassay


Hoehn–Yahr Scale


Interleukin 6


Montgomery Asberg Depression Rating Scale


Mini-mental state examination


Parkinson’s disease


Unified Parkinson’s Disease Rating Scale


Verbal fluency test


Wechsler Memory Scale



We would like to thank to Prof. Egon Kurča, M.D., Ph.D., FESO, Prof. Peter Valkovič, M.D., Ph.D., and Ján Necpal, M.D., for kindly referring their patients for participation in this study and to Anne Johnson for grammatical assistance.

Author contributions

BV: research project: conception, organization, execution; statistical analysis: review and critique; manuscript: writing of the first draft. MD: research project: execution; manuscript: review and critique. VT: research project: execution; manuscript: review and critique. EK: statistical analysis: design, execution, review and critique. MB: research project: execution. SK: research project: execution. TH: research project: execution. IR: research project: conception, organization, execution; statistical analysis: design; manuscript: review and critique.


The study was supported by the Ministry of Education, Youth and Sports of the Czech Republic under the Project CEITEC 2020 (LQ1601).

Compliance with ethical standards

Conflict of interest

None of the authors report any conflict of interest or financial disclosure.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Branislav Veselý
    • 1
    • 3
  • Michal Dufek
    • 2
  • Vojtech Thon
    • 4
  • Miroslav Brozman
    • 1
  • Silvia Királová
    • 5
  • Tatiana Halászová
    • 5
  • Eva Koriťáková
    • 6
  • Ivan Rektor
    • 2
    • 3
  1. 1.Department of Neurology, Faculty HospitalConstantine the Philosopher UniversityNitraSlovak Republic
  2. 2.Movement Disorders Center, First Department of NeurologyMasaryk University, St. Anne’s University HospitalBrnoCzech Republic
  3. 3.Central European Institute of Technology (CEITEC), Brain and Mind Research ProgrammeBrnoCzech Republic
  4. 4.Department of Clinical Immunology and Allergy, Faculty of MedicineMasaryk University, St. Anne’s University HospitalBrnoCzech Republic
  5. 5.Department of Clinical Psychology, Faculty HospitalConstantine the Philosopher UniversityNitraSlovak Republic
  6. 6.Institute of Biostatistics and Analyses, Faculty of MedicineMasaryk UniversityBrnoCzech Republic

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