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Effects of oxytocin and arginine vasopressin on the proliferation and differentiation of a serotonergic cell line

  • Translational Neurosciences - Short communication
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Abstract

The neuropeptides oxytocin and arginine vasopressin (AVP) are involved in the regulation of social behavior and cognition. The current study analyzed the effect of oxytocin and AVP on proliferation and differentiation of serotonergic neurons (RN46A cells). Oxytocin did not affect, while 5–10 μM AVP decreased RN46A proliferation. Oxytocin did not significantly alter, while 10 μM AVP decreased the number of cells extending neurites. We found divergent effects of oxytocin and AVP in serotonergic neurons, underscoring their functional differences.

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Acknowledgements

We thank Prof. Scott Whittemore for kindly providing us the RN46A cell line and Ms. Angela Aeschbach and Ms. Cristina Miralpeix Monclus for their excellent technical assistance with the experimental work. Zoya Marinova reports a Marie Heim-Vögtlin Fellowship from the Swiss Science National Foundation. Funding was provided by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Grant no. 134106).

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Authors and Affiliations

  1. Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zürich, Wagistrasse 12, 8952, Schlieren, Switzerland

    Zoya Marinova, Susanne Walitza & Edna Grünblatt

  2. Neuroscience Center Zürich, University of Zürich and ETH Zürich, Zurich, Switzerland

    Susanne Walitza & Edna Grünblatt

  3. Zürich Center for Integrative Human Physiology, University of Zürich, Zurich, Switzerland

    Susanne Walitza & Edna Grünblatt

Authors
  1. Zoya Marinova
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  2. Susanne Walitza
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  3. Edna Grünblatt
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Correspondence to Zoya Marinova or Edna Grünblatt.

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Marinova, Z., Walitza, S. & Grünblatt, E. Effects of oxytocin and arginine vasopressin on the proliferation and differentiation of a serotonergic cell line. J Neural Transm 125, 103–106 (2018). https://doi.org/10.1007/s00702-017-1778-8

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  • DOI: https://doi.org/10.1007/s00702-017-1778-8

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