Abstract
Transcranial direct current stimulation (tDCS) was applied bilaterally over the auditory cortex in 12 schizophrenia patients to modulate early auditory processing. Performance on a tone discrimination task (tone-matching task—TMT) and auditory mismatch negativity were assessed after counterbalanced anodal, cathodal, and sham tDCS. Cathodal stimulation improved TMT performance (p < 0.03) compared to sham condition. Post-hoc analyses revealed a stimulation condition by negative symptom interaction in which greater negative symptoms were associated with a better TMT performance after anodal tDCS.
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This study was funded by the Veterans Administration (VA) Desert Pacific Veterans Integrated Service Network 22 (VISN 22) Mental Illness Research, Education, and Clinical Center (MIRECC).
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Dunn, W., Rassovsky, Y., Wynn, J. et al. The effect of bilateral transcranial direct current stimulation on early auditory processing in schizophrenia: a preliminary study. J Neural Transm 124, 1145–1149 (2017). https://doi.org/10.1007/s00702-017-1752-5
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DOI: https://doi.org/10.1007/s00702-017-1752-5