The effect of bilateral transcranial direct current stimulation on early auditory processing in schizophrenia: a preliminary study

  • Walter Dunn
  • Yuri Rassovsky
  • Jonathan Wynn
  • Allan D. Wu
  • Marco Iacoboni
  • Gerhard Hellemann
  • Michael F. Green
Psychiatry and Preclinical Psychiatric Studies - Short communication

Abstract

Transcranial direct current stimulation (tDCS) was applied bilaterally over the auditory cortex in 12 schizophrenia patients to modulate early auditory processing. Performance on a tone discrimination task (tone-matching task—TMT) and auditory mismatch negativity were assessed after counterbalanced anodal, cathodal, and sham tDCS. Cathodal stimulation improved TMT performance (p < 0.03) compared to sham condition. Post-hoc analyses revealed a stimulation condition by negative symptom interaction in which greater negative symptoms were associated with a better TMT performance after anodal tDCS.

Keywords

Schizophrenia Transcranial direct current stimulation tDCS Auditory processing Mismatch negativity Tone-matching task 

Supplementary material

702_2017_1752_MOESM1_ESM.docx (164 kb)
Supplementary material 1 (DOCX 163 kb)

Copyright information

© Springer-Verlag GmbH Austria (outside the USA) 2017

Authors and Affiliations

  • Walter Dunn
    • 1
    • 2
    • 6
  • Yuri Rassovsky
    • 3
    • 2
  • Jonathan Wynn
    • 1
    • 2
  • Allan D. Wu
    • 4
  • Marco Iacoboni
    • 2
    • 5
  • Gerhard Hellemann
    • 2
  • Michael F. Green
    • 1
    • 2
  1. 1.Department of Veterans Affairs VISN-22 Mental Illness Research, Education and Clinical CenterLos AngelesUSA
  2. 2.Department of Psychiatry and Biobehavioral SciencesUCLA Semel Institute for Neuroscience and Human BehaviorLos AngelesUSA
  3. 3.Department of Psychology and Gonda Multidisciplinary Brain Research CenterBar-Ilan UniversityRamat-GanIsrael
  4. 4.Department of NeurologyUniversity of CaliforniaLos AngelesUSA
  5. 5.Ahmanson-Lovelace Brain Mapping CenterUniversity of CaliforniaLos AngelesUSA
  6. 6.West Los Angeles VA Medical CenterLos AngelesUSA

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