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The dopamine-related polymorphisms BDNF, COMT, DRD2, DRD3, and DRD4 are not linked with changes in CSF dopamine levels and frequency of HIV infection

  • Psychiatry and Preclinical Psychiatric Studies - Original Article
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Abstract

We showed previously that higher levels in CSF dopamine in HIV patients are associated with the presence of the dopamine transporter (DAT) 10/10-repeat allele which was also detected more frequently in HIV-infected individuals compared to uninfected subjects. In the current study, we investigated further whether other genetic dopamine (DA)-related polymorphisms may be related with changes in CSF DA levels and frequency of HIV infection in HIV-infected subjects. Specifically, we studied genetic polymorphisms of brain-derived neurotrophic factor, catechol-O-methyltransferase, and dopamine receptors DRD2, DRD3, and DRD4 genetic polymorphisms in uninfected and HIV-infected people in two different ethnical groups, a German cohort (Caucasian, 72 individuals with HIV infection and 22 individuals without HIV infection) and a South African cohort (Xhosan, 54 individuals with HIV infection and 19 individuals without HIV infection). We correlated the polymorphisms with CSF DA levels, HIV dementia score, CD4+ T cell counts, and HIV viral load. None of the investigated DA-related polymorphisms was associated with altered CSF DA levels, CD4+ T cell count, viral load, and HIV dementia score. The respective allele frequencies were equally distributed between HIV-infected patients and controls. Our findings do not show any influence of the studied genetic polymorphisms on CSF DA levels and HIV infection. This is in contrast to what we found previously for the DAT 3′UTR VNTR and highlights the specific role of the DAT VNTR in HIV infection and disease.

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Acknowledgements

We are grateful for the study management of Teboho Linda as well as the technical support from Lena Ruthardt. The study was supported by Grants from “Bundesministerium für Bildung und Forschung” (BMBF-KI0211 Competence Network HIV/AIDS) and “Deutsche Forschungsgemeinschaft” (DFG-GRK 1522). Anne Horn had a fellowship for the last year of her PhD Thesis from the “Qualifikationsprogramm für Wissenschaftlerinnen der Universitaet Wuerzburg” (supported by the Bavarian Government).

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Authors and Affiliations

  1. Institute of Virology and Immunobiology, University of Wuerzburg, Versbacher Str. 7, 97078, Wuerzburg, Germany

    Anne Horn, C. Scheller & E. Koutsilieri

  2. Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa

    S. du Plessis

  3. Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany

    R. Burger

  4. Department of Neurology, University Hospital of Duesseldorf, Duesseldorf, Germany

    G. Arendt

  5. Department of Psychiatry, University of Cape Town, Cape Town, South Africa

    J. Joska

  6. IFTZ, Medical University Innsbruck, Innsbruck, Austria

    S. Sopper

  7. Department of Neurology, University Hospital of Duisburg-Essen, Duisburg-Essen, Germany

    C. M. Maschke & M. Obermann

  8. Department of Neurology, University Hospital of Muenster, Muenster, Germany

    I. W. Husstedt

  9. Institute of Mathematics and Informatics, Chair of Mathematics VIII (Statistics), University of Wuerzburg, Wuerzburg, Germany

    J. Hain

  10. Center of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany

    P. Riederer

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  1. Anne Horn
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The German Competence Network HIV/AIDS

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Correspondence to Anne Horn.

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Horn, A., Scheller, C., du Plessis, S. et al. The dopamine-related polymorphisms BDNF, COMT, DRD2, DRD3, and DRD4 are not linked with changes in CSF dopamine levels and frequency of HIV infection. J Neural Transm 124, 501–509 (2017). https://doi.org/10.1007/s00702-016-1659-6

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