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Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome

  • Neurology and Preclinical Neurological Studies - Original Article
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Abstract

A recent meta-analysis suggests an association between the rs11558538 single nucleotide polymorphism in the histamine-N-methyl-transferase (HNMT) gene and the risk for Parkinson’s disease. Based on the possible relationship between PD and restless legs syndrome (RLS), we tried to establish whether rs11558538 SNP is associated with the risk for RLS. We studied the genotype and allelic variant frequencies of HNMT rs11558538 SNP 205 RLS patients and 410 healthy controls using a TaqMan assay. The frequencies of the HNMT rs11558538 genotypes allelic variants were similar between RLS patients and controls, and were not influenced by gender, family history of RLS, or RLS severity. RLS patients carrying the genotype rs11558538TT had an earlier age at onset, but this finding was based on three subjects only. These results suggest a lack of major association between HNMT rs11558538 SNP and the risk for RLS.

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Acknowledgements

This work was supported in part by Grants PI12/00241, PI12/00324, PI15/00303, and RETICS RD12/0013/0002 from Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Madrid, Spain; GR15026 from Junta de Extremadura, Mérida, Spain; PRIS10016 (Fundesalud, Mérida,Spain); grants from the Spanish Ministry of Science and Innovation SAF2006-10126 (2006-2009) and SAF2010-22329-C02-01 (2011-2013) to P.P and by the “Unión Técnica de Empresas” (UTE) project FIMA to P.P. and project from the Centro de Investigaciones Médicas Aplicadas (CIMA), Spain. The study was partially funded by FEDER funds.

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Authors and Affiliations

  1. Section of Neurology, Hospital Universitario del Sureste, C/Marroquina 14, 3º B, 28030, Arganda del Rey, Madrid, Spain

    Félix Javier Jiménez-Jiménez, Hortensia Alonso-Navarro, Francisco Navacerrada, Marisol Calleja, José Francisco Plaza-Nieto, Belén Pilo-de-la-Fuente & Margarita Arroyo-Solera

  2. Department of Medicine-Neurology, Hospital “Príncipe de Asturias”, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain

    Félix Javier Jiménez-Jiménez, Hortensia Alonso-Navarro, Ana Rojo-Sebastián, Lluisa Rubio & Esteban García-Albea

  3. Department of Pharmacology, Universidad de Extremadura, Cáceres, Spain

    Elena García-Martín & José A. G. Agúndez

  4. Department of Pharmacology, University of Extremadura, Badajoz, Spain

    Carmen Martínez

  5. Section of Neurology, Hospital Virgen del Puerto, Plasencia, Cáceres, Spain

    Martín Zurdo

  6. Section of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Ciudad Real, Spain

    Laura Turpín-Fenoll & Jorge Millán-Pascual

  7. Unit of Neurology, Clínica Recoletas, Zamora, Spain

    Teresa Adeva-Bartolomé

  8. Section of Neurology, Hospital Universitario de Burgos, Burgos, Spain

    Esther Cubo

  9. CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Monforte de Lemos Street, Madrid, Spain

    Sara Ortega-Cubero & Pau Pastor

  10. Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, Universidad de Navarra, Pamplona, Spain

    Sara Ortega-Cubero & Pau Pastor

  11. Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain

    Sara Ortega-Cubero & Pau Pastor

  12. Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain

    Pau Pastor

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  1. Félix Javier Jiménez-Jiménez
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  2. Elena García-Martín
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  3. Hortensia Alonso-Navarro
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  18. Margarita Arroyo-Solera
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  19. Esteban García-Albea
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  20. José A. G. Agúndez
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Correspondence to Félix Javier Jiménez-Jiménez.

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Jiménez-Jiménez, F.J., García-Martín, E., Alonso-Navarro, H. et al. Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome. J Neural Transm 124, 285–291 (2017). https://doi.org/10.1007/s00702-016-1645-z

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