Abstract
To investigate the vasomotor regulation in multiple system atrophy (MSA), we simultaneously recorded muscle sympathetic nerve activity (MSNA), heart rate, and blood pressure in 14 MSA patients without syncope and 18 healthy subjects. Resting MSNA bursts were significantly less frequent in MSA patients than healthy subjects (p < 0.001), while the increase of MSNA bursts with head-up tilt was significantly greater in MSA patients (p < 0.01). In patients with MSA, orthostatic hypotension may be prevented by an augmented MSNA response.
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Abbreviations
- MSA:
-
Multiple system atrophy
- HR:
-
Heart rate
- MBP:
-
Mean blood pressure
- MSNA:
-
Muscle sympathetic nerve activity
- OH:
-
Orthostatic hypotension
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The study protocol and procedure were approved by the appropriate local ethics committee. Ethical standards were consistent with the 1964 Declaration of Helsinki and its later amendments.
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Shindo, K., Tsuchiya, M., Ichinose, Y. et al. Vasomotor regulation in patients with multiple system atrophy. J Neural Transm 124, 477–481 (2017). https://doi.org/10.1007/s00702-016-1644-0
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DOI: https://doi.org/10.1007/s00702-016-1644-0