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Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer’s disease

  • Translational Neurosciences - Review Article
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Abstract

It is increasingly recognized that astrocytes and microglia-associated dysfunction contribute to AD pathology. In addition, glial nicotinic acetylcholine receptors (nAChRs) play a role in AD-related phenomena, such as neuron survival, synaptic plasticity, and memory. From mechanistic point of view, the glial regulation of pro-inflammatory cytokines, as common contributors in AD, is modulated by nAChRs. Astrocytic and microglial nAChRs contribute to Aβ metabolism, including Aβ phagocytosis and degradation as well as Aβ-related oxidative stress and neurotoxicity. These receptors are also involved in neurotransmission and gliotransmission through indirect interaction with N-Methyl-d-aspartate (NMDA) and a-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA) receptors as well as gamma-aminobutyric acid (GABA) and intracellular calcium regulation. In addition, glial nAChRs participate in trophic factors-induced neuroprotection. This review gathers the most recent advances along with the previous data on astrocytic and microglial nAChRs role in AD pathogenesis.

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Acknowledgments

The authors would like to express their gratitude to Dr. Mehdi Farhoudi, director of Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.

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  1. Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran

    Saeed Sadigh-Eteghad, Alireza Majdi, Javad Mahmoudi & Mahnaz Talebi

  2. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Samad E. J. Golzari

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  1. Saeed Sadigh-Eteghad
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  2. Alireza Majdi
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Correspondence to Alireza Majdi.

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Sadigh-Eteghad, S., Majdi, A., Mahmoudi, J. et al. Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer’s disease. J Neural Transm 123, 1359–1367 (2016). https://doi.org/10.1007/s00702-016-1580-z

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