Effects of theta-rhythm transcranial alternating current stimulation (4.5 Hz-tACS) in patients with clozapine-resistant negative symptoms of schizophrenia: a case series

Abstract

Our aim was to assess the efficacy and safety of theta-rhythm transcranial Alternating Current Stimulation (4.5 Hz-tACS) in patients with clozapine-resistant symptoms of schizophrenia. In an open case series, 3 patients received 20 sessions of 4.5 Hz-tACS (20 min, 2 mA) applied over the dorsolateral prefrontal cortex. The patients exhibited a decrease of negative symptoms (−10 %), general symptoms (−18 %) and an improvement of insight into the illness (−25 %). 4.5 Hz-tACS might be a suitable alternative treatment for clozapine-resistant symptoms of schizophrenia.

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Correspondence to Jerome Brunelin.

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Kallel, L., Mondino, M. & Brunelin, J. Effects of theta-rhythm transcranial alternating current stimulation (4.5 Hz-tACS) in patients with clozapine-resistant negative symptoms of schizophrenia: a case series. J Neural Transm 123, 1213–1217 (2016). https://doi.org/10.1007/s00702-016-1574-x

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Keywords

  • tACS
  • tDCS
  • Schizophrenia
  • Insight
  • Prefrontal cortex
  • DLPFC