Journal of Neural Transmission

, Volume 123, Issue 10, pp 1213–1217 | Cite as

Effects of theta-rhythm transcranial alternating current stimulation (4.5 Hz-tACS) in patients with clozapine-resistant negative symptoms of schizophrenia: a case series

  • Lassaad Kallel
  • Marine Mondino
  • Jerome BrunelinEmail author
Psychiatry and Preclinical Psychiatric Studies - Short communication


Our aim was to assess the efficacy and safety of theta-rhythm transcranial Alternating Current Stimulation (4.5 Hz-tACS) in patients with clozapine-resistant symptoms of schizophrenia. In an open case series, 3 patients received 20 sessions of 4.5 Hz-tACS (20 min, 2 mA) applied over the dorsolateral prefrontal cortex. The patients exhibited a decrease of negative symptoms (−10 %), general symptoms (−18 %) and an improvement of insight into the illness (−25 %). 4.5 Hz-tACS might be a suitable alternative treatment for clozapine-resistant symptoms of schizophrenia.


tACS tDCS Schizophrenia Insight Prefrontal cortex DLPFC 


Compliance with ethical standards

Conflict of interest

No conflicts to disclose.


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Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  • Lassaad Kallel
    • 1
  • Marine Mondino
    • 2
  • Jerome Brunelin
    • 2
    • 3
    Email author
  1. 1.Résidence ENNESRINE, Cab G12La SoukraTunisia
  2. 2.Centre Interdisciplinaire de Recherche en Réadaptation et en Intégration Sociale, Centre de Recherche de l’Institut Universitaire en Santé Mentale, Medical SchoolUniversité LavalQuébecCanada
  3. 3.INSERM U1028, CNRS UMR5292, Lyon University, University Lyon 1, Lyon Neuroscience Research Center, PSYR2 team: Psychiatric Disorders: from Resistance to Response Team, Centre Hospitalier Le VinatierBronFrance

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