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A genetic variant in CAMKK2 gene is possibly associated with increased risk of bipolar disorder

  • Psychiatry and Preclinical Psychiatric Studies - Original Article
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Abstract

A recent large-scale study have reported that rs1063843, a single nucleotide polymorphism located in the CAMKK2 gene is highly associated with schizophrenia in European and Han Chinese populations. Increasing evidences show that schizophrenia and bipolar disorder have some common genetic variance. Here, we evaluated the association of this variant with schizophrenia and bipolar disorder in Iranian population. Genomic DNA was extracted from peripheral blood of 500 schizophrenic patients, 500 bipolar patients and 500 normal controls and all were genotyped for the rs1063843 using a PCR–RFLP method. The allele frequency of rs1063843 was significantly different in both schizophrenia and bipolar patients comparing to control group. For the first time, we showed that rs1063843 is highly associated with bipolar disorder, although more replication studies are needed to confirm our findings. Our results also support the findings of previous studies suggesting a significant association between rs1063843 and schizophrenia.

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Acknowledgments

We would like to thank our patients and their families. This study was funded by Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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Authors and Affiliations

  1. Department of Biology, Faculty of Basic Sciences, Islamic Azad University, East Tehran Branch (Ghiamdasht), Tehran, Iran

    Minoo Atakhorrami & Elham Moslemi

  2. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Simin Rahimi-Aliabadi, Abolfazl Movafagh, Babak Emamalizadeh, Hamid Ghaedi, Atena Fazeli, Marzieh Motallebi, Shaghayegh Taghavi, Azadeh Ahmadifard, Amir Ehtesham Shafiei Zarneh, Faranak Madadi, Monavvar Andarva & Hossein Darvish

  3. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran

    Javad Jamshidi

  4. Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

    Mina Ohadi

  5. Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

    Arash Mirabzadeh

  6. Department of Psychiatry, Emam Hossien Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Fatemeh Gholipour

  7. Department of Genetics, School of Medicine, Unit of Medical Sciences, Islamic Azad University, Tehran, Iran

    Saeed Mohammadihosseinabad

  8. Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran

    Neda Shahmohammadibeni

Authors
  1. Minoo Atakhorrami
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  2. Simin Rahimi-Aliabadi
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  3. Javad Jamshidi
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  4. Elham Moslemi
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  5. Abolfazl Movafagh
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  6. Mina Ohadi
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  8. Babak Emamalizadeh
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  9. Hamid Ghaedi
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  10. Fatemeh Gholipour
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  12. Marzieh Motallebi
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  13. Shaghayegh Taghavi
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  14. Azadeh Ahmadifard
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  15. Saeed Mohammadihosseinabad
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  16. Amir Ehtesham Shafiei Zarneh
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  17. Neda Shahmohammadibeni
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  18. Faranak Madadi
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  19. Monavvar Andarva
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  20. Hossein Darvish
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Corresponding author

Correspondence to Hossein Darvish.

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Atakhorrami, M., Rahimi-Aliabadi, S., Jamshidi, J. et al. A genetic variant in CAMKK2 gene is possibly associated with increased risk of bipolar disorder. J Neural Transm 123, 323–328 (2016). https://doi.org/10.1007/s00702-015-1456-7

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  • DOI: https://doi.org/10.1007/s00702-015-1456-7

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