Abstract
We retrospectively evaluated the efficacy and safety of high doses of onabotulinumtoxinA (from 600 to 800 units) in 26 patients affected by upper and/or lower limb post-stroke spasticity. They were assessed before, 30 and 90 days after treatment. We observed a significant muscle tone reduction and a significant functional improvement (assessed with the Disability Assessment Scale). No adverse events were reported. In our retrospective analysis the treatment with high doses of onabotulinumtoxinA showed to be effective and safe.
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Conflict of interest
Dr. Baricich, Dr. Cisari and Dr. Invernizzi received educational grants from Allergan, Ipsen and Merz. Dr. Santamato received educational grants from Merz.
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All procedures performed in the study were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.
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Baricich, A., Grana, E., Carda, S. et al. High doses of onabotulinumtoxinA in post-stroke spasticity: a retrospective analysis. J Neural Transm 122, 1283–1287 (2015). https://doi.org/10.1007/s00702-015-1384-6
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DOI: https://doi.org/10.1007/s00702-015-1384-6