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Elevated fecal calprotectin in patients with Alzheimer’s dementia indicates leaky gut

  • Neurology and Preclinical Neurological Studies - Short communication
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Abstract

Fecal concentrations of calprotectin were examined in 22 patients with Alzheimer’s disease (AD) and compared with serum concentrations of aromatic amino acids. Calprotectin concentrations were mean ± SEM 140 ± 31.9 mg/kg, 16 patients (73 %) presented with concentrations outside normal (>50 mg/kg). Concentrations correlated inversely with serum levels of tryptophan, tyrosine and phenylalanine (all p < 0.05). Increased concentrations of fecal calprotectin indicate a disturbed intestinal barrier function in AD patients which could be of relevance for the lowering of essential aromatic amino acids concentrations in the blood.

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Acknowledgments

The authors thank Mr. Simon Geisler and Mr. Thomas Nuener for excellent technical assistance.

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Authors and Affiliations

  1. Department of Gerontology, Landesnervenklinik Wagner-Jauregg Linz, Wagner-Jauregg Weg 15, 4020, Linz, Austria

    Friedrich Leblhuber & Kostja Steiner

  2. Division of Biological Chemistry, Biocenter, Medical University, Innrain 80, 6020, Innsbruck, Austria

    Simon Geisler & Dietmar Fuchs

  3. Biovis Diagnostik MVZ GmbH, Limburg, Germany

    Burkhard Schütz

Authors
  1. Friedrich Leblhuber
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  2. Simon Geisler
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  3. Kostja Steiner
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  4. Dietmar Fuchs
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  5. Burkhard Schütz
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Corresponding author

Correspondence to Dietmar Fuchs.

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Leblhuber, F., Geisler, S., Steiner, K. et al. Elevated fecal calprotectin in patients with Alzheimer’s dementia indicates leaky gut. J Neural Transm 122, 1319–1322 (2015). https://doi.org/10.1007/s00702-015-1381-9

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  • DOI: https://doi.org/10.1007/s00702-015-1381-9

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