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Journal of Neural Transmission

, Volume 122, Issue 9, pp 1319–1322 | Cite as

Elevated fecal calprotectin in patients with Alzheimer’s dementia indicates leaky gut

  • Friedrich Leblhuber
  • Simon Geisler
  • Kostja Steiner
  • Dietmar Fuchs
  • Burkhard Schütz
Neurology and Preclinical Neurological Studies - Short communication

Abstract

Fecal concentrations of calprotectin were examined in 22 patients with Alzheimer’s disease (AD) and compared with serum concentrations of aromatic amino acids. Calprotectin concentrations were mean ± SEM 140 ± 31.9 mg/kg, 16 patients (73 %) presented with concentrations outside normal (>50 mg/kg). Concentrations correlated inversely with serum levels of tryptophan, tyrosine and phenylalanine (all p < 0.05). Increased concentrations of fecal calprotectin indicate a disturbed intestinal barrier function in AD patients which could be of relevance for the lowering of essential aromatic amino acids concentrations in the blood.

Keywords

Alzheimer disease Calprotectin Leaky gut Phenylalanine Tryptophan Tyrosine 

Notes

Acknowledgments

The authors thank Mr. Simon Geisler and Mr. Thomas Nuener for excellent technical assistance.

Conflict of interest

None.

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Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  • Friedrich Leblhuber
    • 1
  • Simon Geisler
    • 2
  • Kostja Steiner
    • 1
  • Dietmar Fuchs
    • 2
  • Burkhard Schütz
    • 3
  1. 1.Department of GerontologyLandesnervenklinik Wagner-Jauregg LinzLinzAustria
  2. 2.Division of Biological Chemistry, BiocenterMedical UniversityInnsbruckAustria
  3. 3.Biovis Diagnostik MVZ GmbHLimburgGermany

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