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Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview

Abstract

Multiple lines of evidence suggest that vascular alterations contribute to Alzheimer’s disease (AD) pathogenesis. It is also well established that mitochondrial abnormalities occur early in course of AD. Here, we give an overview of the vascular and mitochondrial abnormalities occurring in AD, including mitochondrial alterations in vascular endothelial cells within the brain, which is emerging as a common feature that bridges cerebral vasculature and mitochondrial metabolism.

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Acknowledgements

The authors’ work is supported by Quadro de Referência Estratégico Nacional (QREN DO-IT) and Alzheimer’s Association (NIRG-13-282387), by the Semmes Foundation, and by a grant from the National Institute on Minority Health and Health Disparities (G12MD007591) from the National Institutes of Health.

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Correspondence to George Perry or Paula I. Moreira.

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Carvalho, C., Correia, S.C., Perry, G. et al. Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview. J Neural Transm 123, 107–111 (2016). https://doi.org/10.1007/s00702-015-1367-7

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Keywords

  • Alzheimer’s disease
  • Brain vasculature
  • Mitochondria
  • Oxidative stress