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Possible association between DBH 19 bp insertion/deletion polymorphism and clinical symptoms in schizophrenia with tardive dyskinesia

  • Psychiatry and Preclinical Psychiatric Studies - Original Article
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Abstract

Overactivity of dopaminergic neurotransmission is a putative mechanism of tardive dyskinesia (TD). Previous studies have found dysfunction in plasma dopamine beta-hydoxylase (DBH) in schizophrenia with TD. Moreover, DBH, whose activity and levels are strongly controlled by the DBH gene, is a key enzyme in the conversion of dopamine (DA) to norepinephrine (NE) associated with excited behavior. This study examined whether the DBH5′-insertion/deletion (Ins/Del) polymorphism was associated with excited behavior in schizophrenia with TD. The presence of the DBH5′-Ins/Del polymorphism was determined in 741 schizophrenia with TD (n = 345) and without TD (n = 396). The Abnormal Involuntary Movement Scale and Positive and Negative Syndrome Scale were used to assess the severity of TD and psychopathology of schizophrenia. There was no significant difference in the allelic and genotypic frequencies of the DBH5′-Ins/Del polymorphism between schizophrenia with and without TD (both p > 0.05). However, the excited symptoms score was significantly different to the DBH5′-Ins/Del genotypic groups in schizophrenia with TD (p < 0.05) but not in the two groups of non-TD and total patients (both p > 0.05). The excited symptoms score was higher in TD patients with the Del/Del genotype than those with Ins alleles (p = 0.015). Our findings suggest that the DBH5′-Ins/Del polymorphism may not contribute directly to the development of TD in schizophrenia, but it may be involved in the excited behavior of TD patients.

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Acknowledgments

This study was funded by grants from the Beijing Municipal Natural Science Foundation (7132063 and 7072035), National Natural Science Foundation of China (81371477), NARSAD Independent Investigator Grant (20314), the National Key Technology R&D Program in the 11th Five Year Plan of China (2009BAI77B06), and the Wenzhou Municipal Sci-Tech Bureau Program (H20100021). These sources had no further role in study design, data collection and analysis, decision to publish, or preparation of the article.

Conflict of interest

No conflict of interest was disclosed for each author.

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Authors and Affiliations

  1. Institute of Wenzhou Kangning Mental Health, Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China

    Li Hui, Min Jie Ye & Ke Zheng

  2. School of Medicine, IHMRI, University of Wollongong, Wollongong, NSW, Australia

    Mei Han & Xu Feng Huang

  3. Schizophrenia Research Institute, Sydney, NSW, Australia

    Mei Han & Xu Feng Huang

  4. Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China

    Ke Zheng & Jin Cai He

  5. Beijing HuiLongGuan Hospital, Peking University, Beijing, People’s Republic of China

    Meng Han Lv, Bao Hua Zhang & Xiang Yang Zhang

  6. Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX, USA

    Jair C. Soares & Xiang Yang Zhang

  7. Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, Chang-Ping District, Beijing, 100096, People’s Republic of China

    Xiang Yang Zhang

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  1. Li Hui
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Correspondence to Xiang Yang Zhang.

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Hui, L., Han, M., Huang, X.F. et al. Possible association between DBH 19 bp insertion/deletion polymorphism and clinical symptoms in schizophrenia with tardive dyskinesia. J Neural Transm 122, 907–914 (2015). https://doi.org/10.1007/s00702-014-1327-7

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