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Nocturnal manifestations of atypical and vascular parkinsonism: How do they differ from Parkinson’s disease?

  • Neurology and Preclinical Neurological Studies - Original Article
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Abstract

While nocturnal disturbances of Parkinson’s disease (PD) are increasingly recognized as being part of a continuum that includes daytime manifestations, there is still little analysis in the medical literature that assesses these complex phenomena in patients with atypical (AP) and vascular parkinsonisms (VP). The objective of our study was to determine the prevalence of these disturbances in patients with AP and VP and to determine the range of nighttime symptoms that occur compared with those in patients with PD. This comparison was done using a semi-structured interview and self-rated questionnaires in 63 AP and VP patients (PSP 24, MSA 24, CBD 5, and VP 10), and 208 PD patients. 61 AP and VP patients (96.8 %) and 201 PD patients (96.6 %) reported at least one nocturnal symptom with a score of less than 6 on the Modified Parkinson’s Disease Sleep Scale (MPDSS). Nocturnal akinesia, as measured on the Nocturnal Akinesia, Dystonia, and Cramp Score, was found to be significantly greater in patients with PSP (p = 0.006), MSA (p = 0.002), and CBD (p = 0.012) than PD patients, but not VP patients (p = 0.428). Like those with PD, patients with AP and VP identified the problem of getting up at night to urinate (MPDSS item 8) as being the most frequent and troublesome nocturnal symptom. MSA and PSP patients reported more frequent (p = 0.001) and troublesome (p < 0.001) urinary incontinence (MPDSS item 9) than PD patients and MSA patients had more severe problems with unexpectedly falling asleep during the day (MPDSS item 15) than PD patients (p = 0.003). In summary, our study determined that nocturnal manifestations are commonly experienced by patients with AP and VP and highlighted specific nocturnal symptoms, which are more prevalent and troublesome in certain AP syndromes. The concept of 24-h control of symptoms should not be limited to only PD and we recommend that all who are involved in the care of AP and VP patients should realize that many nocturnal symptoms are experienced by these patients and a multidisciplinary approach should be utilized to address these problems.

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References

  • Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J (2003) Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4(2):101–119

    Article  PubMed  Google Scholar 

  • Asahina M, Young TM, Bleasdale-Barr K, Mathias CJ (2005) Differences in overshoot of blood pressure after head-up tilt in two groups with chronic autonomic failure: pure autonomic failure and multiple system atrophy. J Neurol 252(1):72–77. doi:10.1007/s00415-005-0609-2

    Article  PubMed  Google Scholar 

  • Benarroch EE (2013) Pedunculopontine nucleus: functional organization and clinical implications. Neurology 80(12):1148–1155. doi:10.1212/WNL.0b013e3182886a76

    Article  PubMed  Google Scholar 

  • Bhidayasiri R, Truong DD (2012) Therapeutic strategies for nonmotor symptoms in early Parkinson’s disease: the case for a higher priority and stronger evidence. Parkinsonism Relat Disord 18(Suppl 1):S110–S113. doi:10.1016/S1353-8020(11)70035-9

    Article  PubMed  Google Scholar 

  • Bhidayasiri R, Saksornchai K, Kaewwilai L, Phanthumchinda K (2011) A census of movement disorders at a Thai university hospital. J Neurol Sci 301(1–2):31–34. doi:10.1016/j.jns.2010.11.010

    Article  PubMed  Google Scholar 

  • Chaudhuri KR (2002) The basis for day and night-time control of symptoms of Parkinson’s disease. Eur J Neurol 9(Suppl 3):40–43

    Article  PubMed  Google Scholar 

  • Chaudhuri KR, Martinez-Martin P (2004) Clinical assessment of nocturnal disability in Parkinson’s disease: the Parkinson’s Disease Sleep Scale. Neurology 63(8 Suppl 3):S17–S20

    Article  PubMed  Google Scholar 

  • Chaudhuri KR, Pal S, DiMarco A, Whately-Smith C, Bridgman K, Mathew R, Pezzela FR, Forbes A, Hogl B, Trenkwalder C (2002) The Parkinson’s disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson’s disease. J Neurol Neurosurg Psychiatry 73(6):629–635

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Chaudhuri KR, Martinez-Martin P, Schapira AH, Stocchi F, Sethi K, Odin P, Brown RG, Koller W, Barone P, MacPhee G, Kelly L, Rabey M, MacMahon D, Thomas S, Ondo W, Rye D, Forbes A, Tluk S, Dhawan V, Bowron A, Williams AJ, Olanow CW (2006) International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson’s disease: the NMSQuest study. Mov Disord 21(7):916–923. doi:10.1002/mds.20844

    Article  PubMed  Google Scholar 

  • Colosimo C, Morgante L, Antonini A, Barone P, Avarello TP, Bottacchi E, Cannas A, Ceravolo MG, Ceravolo R, Cicarelli G, Gaglio RM, Giglia L, Iemolo F, Manfredi M, Meco G, Nicoletti A, Pederzoli M, Petrone A, Pisani A, Pontieri FE, Quatrale R, Ramat S, Scala R, Volpe G, Zappulla S, Bentivoglio AR, Stocchi F, Trianni G, Del Dotto P, Simoni L, Marconi R; Priamo Study G (2010) Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study. J Neurol 257 (1):5–14. doi:10.1007/s00415-009-5255-7

  • De Bruin VS, Machado C, Howard RS, Hirsch NP, Lees AJ (1996) Nocturnal and respiratory disturbances in Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). Postgrad Med J 72(847):293–296

    Article  PubMed Central  PubMed  Google Scholar 

  • Donker Kaat L, Boon AJ, Kamphorst W, Ravid R, Duivenvoorden HJ, van Swieten JC (2007) Frontal presentation in progressive supranuclear palsy. Neurology 69(8):723–729. doi:10.1212/01.wnl.0000267643.24870.26

    Article  CAS  PubMed  Google Scholar 

  • Gibb WR, Lees AJ (1988) The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease. J Neurol Neurosurg Psychiatry 51(6):745–752

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Durr A, Fowler CJ, Kaufmann H, Klockgether T, Lees A, Poewe W, Quinn N, Revesz T, Robertson D, Sandroni P, Seppi K, Vidailhet M (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71(9):670–676. doi:10.1212/01.wnl.0000324625.00404.15

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Glass PG, Lees AJ, Bacellar A, Zijlmans J, Katzenschlager R, Silveira-Moriyama L (2012) The clinical features of pathologically confirmed vascular parkinsonism. J Neurol Neurosurg Psychiatry 83(10):1027–1029. doi:10.1136/jnnp-2012-302828

    Article  PubMed  Google Scholar 

  • Grandas F, Iranzo A (2004) Nocturnal problems occurring in Parkinson’s disease. Neurology 63(8 Suppl 3):S8–S11

    Article  CAS  PubMed  Google Scholar 

  • Guy W (1976) Clinical global impression. In: ECDEU Assessment Manual for Psychopharmacology-revised. National Institute of Mental Health, Rockville, MD

  • Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17(5):427–442

    Article  CAS  PubMed  Google Scholar 

  • Jenkinson C, Fitpatrick R, Peto V, Dummett S, Morley D, Saunders P (2012) The Parkinson’s disease questionnaire. Health Services Research Unit, Univerisity of Oxford, Oxford

    Google Scholar 

  • Lee CN, Kim M, Lee HM, Jang JW, Lee SM, Kwon DY, Park KW, Koh SB (2013) The interrelationship between non-motor symptoms in Atypical Parkinsonism. J Neurol Sci 327(1–2):15–21. doi:10.1016/j.jns.2013.01.034

    Article  PubMed  Google Scholar 

  • Lees AJ, Blackburn NA, Campbell VL (1988) The nighttime problems of Parkinson’s disease. Clin Neuropharmacol 11(6):512–519

    Article  CAS  PubMed  Google Scholar 

  • Litvan I (2005) What is an atypical parkinsonian disorder? In: Litvan I (ed) Atypical parkinsonian disorders: clinical and research aspects. Humana Press, Totowa, pp 1–10

    Chapter  Google Scholar 

  • Litvan I, Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC, Goetz CG, Golbe LI, Grafman J, Growdon JH, Hallett M, Jankovic J, Quinn NP, Tolosa E, Zee DS (1996) Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 47(1):1–9

    CAS  PubMed  Google Scholar 

  • Mackenzie IRA (2005) Neuropathology of atypical parkinsonian disorders. In: Litvan I (ed) Atypical parkinsonian disorders: clinical and research aspects. Humana Press, Totowa, pp 33–64

    Chapter  Google Scholar 

  • Moreno-Lopez C, Santamaria J, Salamero M, Del Sorbo F, Albanese A, Pellecchia MT, Barone P, Overeem S, Bloem B, Aarden W, Canesi M, Antonini A, Duerr S, Wenning GK, Poewe W, Rubino A, Meco G, Schneider SA, Bhatia KP, Djaldetti R, Coelho M, Sampaio C, Cochen V, Hellriegel H, Deuschl G, Colosimo C, Marsili L, Gasser T, Tolosa E (2011) Excessive daytime sleepiness in multiple system atrophy (SLEEMSA study). Arch Neurol 68(2):223–230. doi:10.1001/archneurol.2010.359

    Article  PubMed  Google Scholar 

  • Reimann M, Schmidt C, Herting B, Prieur S, Junghanns S, Schweitzer K, Globas C, Schoels L, Reichmann H, Berg D, Ziemssen T (2010) Comprehensive autonomic assessment does not differentiate between Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy. J Neural Transm 117(1):69–76. doi:10.1007/s00702-009-0313-y

    Article  PubMed  Google Scholar 

  • Riley DE, Lang AE (2000) Clinical diagnostic criteria of corticobasal degeneration. Adv Neurol 82:29–34

    CAS  PubMed  Google Scholar 

  • Roche S, Jacquesson JM, Destee A, Defebvre L, Derambure P, Monaca C (2007) Sleep and vigilance in corticobasal degeneration: a descriptive study. Neurophysiol Clin 37(4):261–264. doi:10.1016/j.neucli.2007.05.002

    Article  CAS  PubMed  Google Scholar 

  • Silber MH, Levine S (2000) Stridor and death in multiple system atrophy. Mov Disord 15(4):699–704

    Article  CAS  PubMed  Google Scholar 

  • Stocchi F, Barbato L, Nordera G, Berardelli A, Ruggieri S (1998) Sleep disorders in Parkinson’s disease. J Neurol 245(Suppl 1):S15–S18

    Article  PubMed  Google Scholar 

  • Tanasanvimon S, Ayuthaya NI, Phanthumchinda K (2007) Modified Parkinson’s disease sleep scale (MPDSS) in Thai Parkinson’s disease patients. J Med Assoc Thai 90(11):2277–2283

    PubMed  Google Scholar 

  • Train the Brain Forum Committee (1993) Thai mental state examination. Siriraj Hosp Gaz 45(6):359–374

    Google Scholar 

  • Trenkwalder C, Kies B, Rudzinska M, Fine J, Nikl J, Honczarenko K, Dioszeghy P, Hill D, Anderson T, Myllyla V, Kassubek J, Steiger M, Zucconi M, Tolosa E, Poewe W, Surmann E, Whitesides J, Boroojerdi B, Chaudhuri KR; Recover Study G (2011) Rotigotine effects on early morning motor function and sleep in Parkinson’s disease: a double-blind, randomized, placebo-controlled study (RECOVER). Mov Disord 26 (1):90–99. doi:10.1002/mds.23441

    Google Scholar 

  • Wenning GK Geser F, Krismer F, Seppi K, Duerr S, Boesch S, Kollensperger M, Goebel G, Pfeiffer KP, Barone P, Pellecchia MT, Quinn NP, Koukouni V, Fowler CJ, Schrag A, Mathias CJ, Giladi N, Gurevich T, Dupont E, Ostergaard K, Nilsson CF, Widner H, Oertel W, Eggert KM, Albanese A, del Sorbo F, Tolosa E, Cardozo A, Deuschl G, Hellriegel H, Klockgether T, Dodel R, Sampaio C, Coelho M, Djaldetti R, Melamed E, Gasser T, Kamm C, Meco G, Colosimo C, Rascol O, Meissner WG, Tison F, Poewe W, European Multiple System Atrophy Study G (2013) The natural history of multiple system atrophy: a prospective European cohort study. Lancet Neurol 12 (3):264–274. doi:10.1016/S1474-4422(12)70327-7

    Google Scholar 

  • Wenning GK, Litvan I, Tolosa E (2011) Milestones in atypical and secondary parkinsonisms. Mov Disord 26(6):1083–1095. doi:10.1002/mds.23713

    Article  PubMed  Google Scholar 

  • Zijlmans JC, Daniel SE, Hughes AJ, Revesz T, Lees AJ (2004) Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis. Mov Disord 19(6):630–640. doi:10.1002/mds.20083

    Article  PubMed  Google Scholar 

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Acknowledgments

The study was supported by the Rachadaphiseksomphot Endowment Fund of the “Strengthen CU’s Researcher’s Project” and research unit (RU) Grant number GRU 56-012-30-002 of Chulalongkorn Center of Excellence on Parkinson’s Disease and Related Disorders, Chulalongkorn University, Bangkok, Thailand. We would like to thank Ratanaruedee Devahastin, Onnalin Jandaew, and Kamolwan Boonpeng for their assistance in patient recruitment and data assortment.

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Authors and Affiliations

  1. Chulalongkorn Center of Excellence on Parkinson’s Disease and Related Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University Hospital and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama 4 Road, Bangkok, 10330, Thailand

    Roongroj Bhidayasiri, Onanong Jitkritsadakul, Sitthi Petchrutchatachart, Lalita Kaewwilai, Pattamon Panyakaew & Nonglak Boonrod

  2. Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, 90095, USA

    Roongroj Bhidayasiri

  3. Dipartimento di Scienze Neurologische, Sapienza Universita di Roma, 00185, Rome, Italy

    Carlo Colosimo

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  1. Roongroj Bhidayasiri
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  7. Carlo Colosimo
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Correspondence to Roongroj Bhidayasiri.

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Bhidayasiri, R., Jitkritsadakul, O., Petchrutchatachart, S. et al. Nocturnal manifestations of atypical and vascular parkinsonism: How do they differ from Parkinson’s disease?. J Neural Transm 121 (Suppl 1), 69–77 (2014). https://doi.org/10.1007/s00702-014-1198-y

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  • DOI: https://doi.org/10.1007/s00702-014-1198-y

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