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Association of antinociceptive action of botulinum toxin type A with GABA-A receptor

Abstract

The mechanism of botulinum toxin type A (BTX-A) antinociceptive action in the central nervous system is little known. The potential interaction between BTX-A and GABAergic system has not been investigated previously. In the present study, we demonstrate prevention of BTX-A antinociceptive effect on formalin-induced inflammatory pain and partial sciatic nerve transection-induced mechanical allodynia by GABA-A antagonist bicuculline, thus suggesting association of the GABA-A receptors and antinociceptive action of BTX-A.

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Correspondence to Z. Lacković.

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Drinovac, V., Bach-Rojecky, L. & Lacković, Z. Association of antinociceptive action of botulinum toxin type A with GABA-A receptor. J Neural Transm 121, 665–669 (2014). https://doi.org/10.1007/s00702-013-1150-6

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Keywords

  • Botulinum toxin type A
  • Neuropathic pain
  • Formalin-induced pain
  • GABA
  • c-Fos