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Association of antinociceptive action of botulinum toxin type A with GABA-A receptor

  • Neurology and Preclinical Neurological Studies - Short communication
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Abstract

The mechanism of botulinum toxin type A (BTX-A) antinociceptive action in the central nervous system is little known. The potential interaction between BTX-A and GABAergic system has not been investigated previously. In the present study, we demonstrate prevention of BTX-A antinociceptive effect on formalin-induced inflammatory pain and partial sciatic nerve transection-induced mechanical allodynia by GABA-A antagonist bicuculline, thus suggesting association of the GABA-A receptors and antinociceptive action of BTX-A.

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Authors and Affiliations

  1. Department of Pharmacology, University of Zagreb Faculty of Pharmacy and Biochemistry, Domagojeva 2, 10000, Zagreb, Croatia

    V. Drinovac & L. Bach-Rojecky

  2. Laboratory of Molecular Neuropharmacology, Department of Pharmacology and Croatian Brain Research Institute, University of Zagreb School of Medicine, Šalata 11, 10000, Zagreb, Croatia

    Z. Lacković

Authors
  1. V. Drinovac
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  2. L. Bach-Rojecky
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  3. Z. Lacković
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Correspondence to Z. Lacković.

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Drinovac, V., Bach-Rojecky, L. & Lacković, Z. Association of antinociceptive action of botulinum toxin type A with GABA-A receptor. J Neural Transm 121, 665–669 (2014). https://doi.org/10.1007/s00702-013-1150-6

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  • DOI: https://doi.org/10.1007/s00702-013-1150-6

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