Abstract
Patients with Parkinson’s disease receive selective irreversible monoamine oxidase (MAO)-B inhibitors, but their effects on MAO-A activity are not known during long-term application. We determined MAO-A inhibition in plasma samples from patients with MAO-B inhibitor intake or without MAO-B inhibitor treatment and from healthy controls. We detected a 70 % reduction of MAO-A activity in patients with MAO-B inhibitor therapy in comparison to the other groups. Our results suggest that treatment with MAO-B inhibitor may also influence MAO-A activity in vivo, when administered daily.
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Acknowledgments
We would like to thank the patients and Gabi Öhm, Marion Marg, Hartmut Rothe, Matthias Küchler, Claudia Kraitzizek, Sven Lütge, Thomas Haas.
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The authors declare neither competing financial interests regarding this research project nor conflicts of interest with respect to the content of the article.
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J. Bartl and T. Müller contributed equally. M. Gerlach and P. Riederer contributed equally.
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Bartl, J., Müller, T., Grünblatt, E. et al. Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity. J Neural Transm 121, 379–383 (2014). https://doi.org/10.1007/s00702-013-1120-z
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DOI: https://doi.org/10.1007/s00702-013-1120-z