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Biomarkers of cognitive dysfunction in traumatic brain injury

  • Neurology and Preclinical Neurological Studies - Review Article
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Abstract

Acetylcholine, glutamate, dopamine, serotonin (5-HT), gamma-aminobutyric acid, substance P (SP), amyloid-β (Aβ) and neurotrophic protein S100B are arguably the most important cognition-related biomarkers in the brain. Among this list are five neurotransmitters that signal through postsynaptic receptors. Our knowledge of cognition-related biomarkers has been advanced through translational experiments and clinical case-study data. Although these biomarkers are widespread in the brain and pronounced individual variations exist, these biomarkers can be used to identify both acute and chronic abnormalities following traumatic brain injury. Changes in these biomarkers likely indicate damage to brain networks or to key brain cell types that support cognitive functions. Identification of such biomarker abnormalities could result in earlier diagnoses, improved prognoses and therapies that enable neurotransmitters to return to normal levels.

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Acknowledgments

This study was supported by grants from the Shanghai Committee of Science and Technology (No. 114119a8300), Shanghai Health Bureau (No. 2010167) and BaoShan Scientific and Technological Development Fund (11-E-1).

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  1. Department of Neurosurgery, No. 3 People’s Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China

    Zhao-Liang Sun & Dong-Fu Feng

  2. Institute of Traumatic Medicine, Shanghai Jiaotong University School of Medicine, 280 Mo-He Road, Shanghai, 201900, China

    Dong-Fu Feng

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Correspondence to Dong-Fu Feng.

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Sun, ZL., Feng, DF. Biomarkers of cognitive dysfunction in traumatic brain injury. J Neural Transm 121, 79–90 (2014). https://doi.org/10.1007/s00702-013-1078-x

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