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The dopamine receptor D1 gene is associated with the length of interval between first heroin use and onset of dependence in Chinese Han heroin addicts

  • Psychiatry and Preclinical Psychiatric Studies - Original Article
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Abstract

Previous researches showed that the dopamine receptor D1 (DRD1) may play a critical role in drug dependence. This research aimed to determine whether DRD1 played a role in development of heroin dependence in Chinese heroin-dependent patients. 465 Chinese Han heroin-dependent subjects and 379 healthy controls were recruited in the Shanghai region. Five single-nucleotide-polymorphisms (SNPs) of the DRD1 gene were genotyped in all subjects. The results found that the frequencies of DRD1 SNP genotypes or haplotypes were not different between heroin-dependent patients and controls. Among heroin-dependent patients, subjects with rs5326CC and/or rs6882300AA genotypes develop to heroin-dependent more rapidly than those without rs5326CC and/or rs6882300AA genotypes. The results indicated that DRD1 gene polymorphism may not play an important role in the susceptibility of heroin dependence in the Chinese Han population, but it may be associated with the rapidity of heroin dependence development from first drug use.

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Acknowledgments

This study was supported by a grant from the Chinese National Basic Science Foundation (30971048, 81271468, 81130020), Shanghai One Hundred Talent Project (XBR2011015). The authors wish to thank Professor Walter Ling (Integrated Substance Abuse Programs, Department Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA) for his help on language improvement.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, 200030, China

    Sufang Peng, Jiang Du, Haifeng Jiang, Yingmei Fu, Hanhui Chen, Haiming Sun, Dongxiang Wang, Shunying Yu & Min Zhao

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  1. Sufang Peng
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  2. Jiang Du
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  3. Haifeng Jiang
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  4. Yingmei Fu
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  5. Hanhui Chen
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  6. Haiming Sun
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  7. Dongxiang Wang
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  8. Shunying Yu
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  9. Min Zhao
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Corresponding authors

Correspondence to Shunying Yu or Min Zhao.

Additional information

M. Zhao and S. Yu contributed equally to this work.

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Peng, S., Du, J., Jiang, H. et al. The dopamine receptor D1 gene is associated with the length of interval between first heroin use and onset of dependence in Chinese Han heroin addicts. J Neural Transm 120, 1591–1598 (2013). https://doi.org/10.1007/s00702-013-1029-6

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  • DOI: https://doi.org/10.1007/s00702-013-1029-6

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