Journal of Neural Transmission

, Volume 120, Issue 4, pp 607–611 | Cite as

The neuropsychiatric profile of Parkinson’s disease subjects with and without mild cognitive impairment

  • Roberto Monastero
  • Paola Di Fiore
  • Giusi D. Ventimiglia
  • Rosolino Camarda
  • Cecilia Camarda
Neurology and Preclinical Neurological Studies - Original Article


Neuropsychiatric symptoms (NPS) are common clinical features of Parkinson’s disease (PD). However, NPS profiles in PD subjects with mild cognitive impairment (MCI) have scarcely been investigated. We aimed to describe the NPS profiles of non-demented PD subjects with and without MCI. A total of 410 non-demented PD subjects were included. Of these, 164 were cognitively normal PD subjects (PD-cn), 142 PD had amnestic MCI (PD-aMCI), and 104 had PD with non-amnestic MCI (PD-naMCI). NPS were evaluated in accordance with the Neuropsychiatric Inventory (NPI). PD-aMCI subjects revealed the highest NPS burden, followed by PD-naMCI and then PD-cn. Overall, the most common NPS in PD-MCI were in order: depression, sleep disturbance, anxiety and apathy. Irritability was significantly associated with PD-aMCI and PD-naMCI. Prospective studies are required to evaluate the significance, clinical correlates and prognostic role of NPS in subject with PD-MCI.


Parkinson’s disease Cognitive impairment Neuropsychiatric symptoms Epidemiology 


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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Roberto Monastero
    • 1
  • Paola Di Fiore
    • 1
  • Giusi D. Ventimiglia
    • 1
  • Rosolino Camarda
    • 1
  • Cecilia Camarda
    • 1
  1. 1.Laboratory of Epidemiology and Psychology of Aging and Dementia (LEPAD), Department of Experimental Biomedicine and Clinical Neuroscience (BioNeC)University of PalermoPalermoItaly

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