Advertisement

Journal of Neural Transmission

, Volume 120, Issue 5, pp 799–806 | Cite as

Age-related changes in parietal lobe activation during an episodic memory retrieval task

  • Christiane S. H. Oedekoven
  • Andreas Jansen
  • Tilo T. Kircher
  • Dirk T. Leube
Neurology and Preclinical Neurological Studies - Original Article

Abstract

The crucial role of lateral parietal regions in episodic memory has been confirmed in previous studies. While aging has an influence on retrieval of episodic memory, it remains to be examined how the involvement of lateral parietal regions in episodic memory changes with age. We investigated episodic memory retrieval in two age groups, using faces as stimuli and retrieval success as a measure of episodic memory. Young and elderly participants showed activation within a similar network, including lateral and medial parietal as well as prefrontal regions, but elderly showed a higher level of brain activation regardless of condition. Furthermore, we examined functional connectivity in the two age groups and found a more extensive network in the young group, including correlations of parietal and prefrontal regions. In the elderly, the overall stronger activation related to memory performance may indicate a compensatory process for a less extensive functional network.

Keywords

Aging Parietal cortex Episodic memory retrieval Functional connectivity 

References

  1. Andersen RA, Buneo CA (2002) Intentional maps in posterior parietal cortex. Annu Rev Neurosci 25:189–220PubMedCrossRefGoogle Scholar
  2. Andrews-Hanna JR, Snyder AZ, Vincent JL, Lustig C, Head D, Raichle ME et al (2007) Disruption of large-scale brain systems in advanced aging. Neuron 56:924–935PubMedCrossRefGoogle Scholar
  3. Bedenbender J, Paulus FM, Krach S, Pyka M, Sommer J, Krug A et al. (2011) Functional connectivity analyses in imaging genetics: considerations on methods and data interpretation. Plos One 6:(12)Google Scholar
  4. Berryhill ME, Phuong L, Picasso L, Cabeza R, Olson IR (2007) Parietal lobe and episodic memory: bilateral damage causes impaired free recall of autobiographical memory. J Neurosci 27:14415–14423PubMedCrossRefGoogle Scholar
  5. Cabeza R, Nyberg L (2000) Imaging cognition: II an empirical review of 275 PET and fMRI studies. J Cog Neurosci 12:1–47CrossRefGoogle Scholar
  6. Cabeza R, Anderson ND, Locantore JK, McIntosh AR (2002) Aging gracefully: compensatory brain activity in high-performing older adults. Neuroimage 17:1394–1402PubMedCrossRefGoogle Scholar
  7. Cabeza R, Ciaramelli E, Olson IR, Moscovitch M (2008) The parietal cortex and episodic memory: an attentional account. Nat Rev Neurosci 9:613–625PubMedCrossRefGoogle Scholar
  8. Ciaramelli E, Grady C, Moscovitch M (2008) Top-down and bottom-up attention to memory: a hypothesis (AtoM) on the role of the posterior parietal cortex in memory retrieval. Neuropsychologia 46:1828–1851PubMedCrossRefGoogle Scholar
  9. Corbetta M, Shulman GL (2002) Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci 3:201–215PubMedCrossRefGoogle Scholar
  10. Craik FIM, Rose NS (2012) Memory encoding and aging: a neurocognitive perspective. Neurosci Biobehav Rev 36:1729–1739PubMedCrossRefGoogle Scholar
  11. Daselaar SM, Prince SE, Dennis NA, Hayes SM, Kim H, Cabeza R (2009) Posterior midline and ventral parietal activity is associated with retrieval success and encoding failure. Front Hum Neurosci 3:1–10CrossRefGoogle Scholar
  12. Duarte A, Henson RN, Graham KS (2008) The Effects of Aging on the Neural Correlates of Subjective and Objective Recollection. Cereb Cortex 18:2169–2180PubMedCrossRefGoogle Scholar
  13. Grady CL (2008) Cognitive neuroscience of aging. Ann N Y AcadSci 1124:127–144CrossRefGoogle Scholar
  14. Grady CL, Bernstein LJ, Beig S, Siegenthaler AL (2002) The effects of encoding strategy on age-related changes in the functional neuroanatomy of face memory. Psychol Aging 17:7–23PubMedCrossRefGoogle Scholar
  15. Grady CL, Springer MV, Hongwanishkul D, McIntosh AR, Winocur G (2006) Age-related changes in brain activity across the adult lifespan. J Cog Neurosci 18:227–241CrossRefGoogle Scholar
  16. Grady CL, Protzner AB, Kovacevic N, Strother SC, Afshin-Pour B, Wojtowicz M et al (2009) A multivariate analysis of age-related differences in default mode and task-positive networks across multiple cognitive domains. Cereb Cortex 20:1432–1447PubMedCrossRefGoogle Scholar
  17. Haramati S, Soroker N, Dudai Y, Levy DA (2008) The posterior parietal cortex in recognition memory: a neuropsychological study. Neuropsychologia 46:1756–1766PubMedCrossRefGoogle Scholar
  18. Hedden T, Gabrieli JDE (2004) Insights into the ageing mind: a view from cognitive neuroscience. Nat Rev Neurosci 5:87–96PubMedCrossRefGoogle Scholar
  19. Henson RN, Rugg MD, Shallice T, Josephs O, Dolan RJ (1999) Recollection and familiarity in recognition memory: an event-related functional magnetic resonance imaging study. J Neurosci 19:3962–3972PubMedGoogle Scholar
  20. Huang CH, Polk TA, Goh JO, Park DC (2012) Both left and right posterior parietal activations contribute to compensatory processes in normal aging. Neuropsychologia 50:55–66PubMedCrossRefGoogle Scholar
  21. Hutchinson JB, Uncapher MR, Wagner AD (2009) Posterior parietal cortex and episodic retrieval: convergent and divergent effects of attentionand memory. Learn Mem 16:343–356PubMedCrossRefGoogle Scholar
  22. Ishai A, Yago E (2006) Recognition memory of newly learned faces. Brain Res Bull 71:167–173PubMedCrossRefGoogle Scholar
  23. Jonker C, Geerlings MI, Schmand B (2000) Are memory complaints predictive for dementia? A review of clinical and population-based studies. Int J Geriatr Psychiatry 15:983–991PubMedCrossRefGoogle Scholar
  24. Koch W, Teipel S, Mueller S, Benninghoff J, Wagner M, Bokde ALW et al (2012) Diagnostic power of default mode network resting state fMRI in the detection of Alzheimer’s disease. Neurobiol Aging 33:466–478PubMedCrossRefGoogle Scholar
  25. Leube DT, Erb M, Grodd W, Bartels M, Kircher TT (2003) Successful episodicmemory retrieval of newly learned faces activates a left fronto-parietal network. Cog Brain Res 18:97–101CrossRefGoogle Scholar
  26. Lustig C, Snyder AZ, Bhakta M, O’Brien KC, McAvoy M, Raichle ME et al (2003) Functional deactivations: change with age and dementia of the Alzheimer type. Proc Natl Acad Sci USA 100:14504–14509PubMedCrossRefGoogle Scholar
  27. McDermott KB, Szpunar KK, Christ SE (2009) Laboratory-based and autobiographical retrieval tasks differ substantially in their neural substrates. Neuropsychologia 47:2290–2298PubMedCrossRefGoogle Scholar
  28. Miller SL, Celone K, DePeau K, Diamond E, Dickerson BC, Rentz D, Pihlajamaki M, Sperling RA (2008) Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation. Proc Natl Acad Sci USA 105:2181–2186PubMedCrossRefGoogle Scholar
  29. Minear M, Park DC (2004) A lifespan database of adult facial stimuli. Behav Res Methods Instrum Comput 36:630–633PubMedCrossRefGoogle Scholar
  30. Nelson SM, Cohen AL, Power JD, Wig GS, Miezin FM, Wheeler ME et al (2010) A parcellation scheme for human left lateral parietal cortex. Neuron 67:156–170PubMedCrossRefGoogle Scholar
  31. Price CJ, Friston KJ (1999) Scanning patients with tasks they can perform. Hum Brain Mapp 8:102–108PubMedCrossRefGoogle Scholar
  32. Reuter-Lorenz PA, Park DC (2010) Human neuroscience and the aging mind: a new look at old problems. J Gerontol Psychol Sci 65:405–415CrossRefGoogle Scholar
  33. Shannon BJ, Buckner RL (2004) Functional-anatomic correlates of memory retrieval that suggest nontraditional processing roles for multiple distinct regions within posterior parietal cortex. J Neurosci 24:10084–10092PubMedCrossRefGoogle Scholar
  34. Simons JS, Peers PV, Hwang DY, Ally BA, Fletcher PC, Budson AE (2008) Is the parietal lobe necessary for recollection in humans? Neuropsychologia 46:1185–1191PubMedCrossRefGoogle Scholar
  35. Spaniol J, Davidson PSR, Kim ASN, Han H, Moscovitch M, Grady CL (2009) Event-related fMRI studies of episodic encoding and retrieval: meta-analyses using activation likelihood estimation. Neuropsychologia 47:1765–1779PubMedCrossRefGoogle Scholar
  36. Stevens WD, Hasher L, Chiew KS, Grady CL (2008) A neural mechanism underlying memory failure in older adults. J Neurosci 28:12820–12824PubMedCrossRefGoogle Scholar
  37. Tulving E (1985) Memory and consciousness. Can Psychol 26:1–12CrossRefGoogle Scholar
  38. Vannini P, O’Brien J, O’Keefe K, Pihlajamaki M, LaViolette P, Sperling RA (2011) What goes down must come up: role of the posteromedial cortices in encoding and retrieval. Cereb Cortex 21:22–34PubMedCrossRefGoogle Scholar
  39. Viard A, Desgranges B, Eustache F, Piolino P (2012) Factors affecting medial temporal lobe engagement for past and future episodic events: an ALE meta-analysis of neuroimaging studies. Brain Cog 80:111–125CrossRefGoogle Scholar
  40. Vilberg KL, Rugg MD (2008) Memory retrieval and the parietal cortex: a review of evidence from a dual-process perspective. Neuropsychologia 46:1787–1799PubMedCrossRefGoogle Scholar
  41. Voss MW, Prakash RS, Erickson KI, Basak C, Chaddock L, Kim JS et al (2010) Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Front Aging Neurosci 2:1–17Google Scholar
  42. Wang L, LaViolette P, O’Keefe K, Putcha D, Bakkour A, Van Dijk KR et al (2010) Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals. Neuroimage 51:910–917PubMedCrossRefGoogle Scholar
  43. Wheeler ME, Buckner RL (2004) Functional-anatomic correlates of remembering and knowing. Neuroimage 21:1337–1349PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  • Christiane S. H. Oedekoven
    • 1
  • Andreas Jansen
    • 1
  • Tilo T. Kircher
    • 1
  • Dirk T. Leube
    • 1
  1. 1.Department of Psychiatry and Psychotherapy, Clinic of Psychiatry and PsychotherapyPhilipps-University MarburgMarburgGermany

Personalised recommendations