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Methylphenidate (MPH) promotes visual cortical activation in healthy adults in a cued visuomotor task

  • Biological Psychiatry - Original Article
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Abstract

Seeking for the mechanisms by which methylphenidate (MPH) improves behavior has demonstrated that MPH modulates excitability in the primary motor cortex. However, little is known about the influence of MPH on top-down controlled mechanisms in the sensory domain. The present study explored the effects of MPH on the activation of visual cortices in healthy adults who performed a cued visuo-motor task in a double-blind placebo-controlled crossover design. Two distinct measures, posterior alpha power and occipital slow cortical potentials (SCPs), were used to reflect raise in excitability and attention-based activation of visual cortical areas. According to the results, performance parameters (reaction time, response variance and error rate) were not affected by MPH. At the neurophysiologic level reflected by reduced alpha power, MPH increased the overall excitability of the occipital cortex, but not the parietal cortex. Before the cued response, MPH reduced alpha power and increased SCPs only before right hand responses, mostly at the right occipital location. It can be concluded that in visuo-motor tasks, MPH has the potency of adjusting the background excitation/inhibition balance of visual areas. Additionally, MPH may raise the attention controlled activation of visual cortical regions, especially during increased response control.

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Acknowledgments

The study was supported by EU COST action B27 ENOC (Electric Neuronal Oscillations and Cognition). The authors are thankful to Martin Deinzer for technical assistance and data recording.

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Authors and Affiliations

  1. Institute of Neurobiology, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

    Yordan Hodzhev, Juliana Yordanova & Vasil Kolev

  2. Child and Adolescent Psychiatry, University of Erlangen, 91054, Erlangen, Germany

    Martin Diruf, Oliver Kratz, Gunter H. Moll & Hartmut Heinrich

  3. Heckscher-Klinikum, 81539, Munich, Germany

    Hartmut Heinrich

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  1. Yordan Hodzhev
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  2. Juliana Yordanova
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  3. Martin Diruf
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  4. Oliver Kratz
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  5. Gunter H. Moll
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  6. Vasil Kolev
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  7. Hartmut Heinrich
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Correspondence to Hartmut Heinrich.

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Hodzhev, Y., Yordanova, J., Diruf, M. et al. Methylphenidate (MPH) promotes visual cortical activation in healthy adults in a cued visuomotor task. J Neural Transm 119, 1455–1464 (2012). https://doi.org/10.1007/s00702-012-0799-6

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  • DOI: https://doi.org/10.1007/s00702-012-0799-6

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