Abstract
Wechsler adult intelligence scale-revised was performed in 576 healthy adults to examine whether a functional polymorphism (Asp358Ala) of the IL-6 receptor (IL-6R) gene is associated with cognitive performance. Verbal intelligence quotient in Asp homozygotes was significantly higher compared to Ala carriers (P = 0.005). Compared to Ala carriers, Asp homozygotes performed better in the verbal subtests requiring long-term memory stores. Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory.
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Acknowledgments
This study was supported by Health and Labor Sciences Research Grants (Comprehensive Research on Disability, Health, and Welfare), Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS), Core Research of Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), the Strategic Research Program for Brain Sciences by the Ministry of Education, Culture, Sports, Science and Technology of Japan (Understanding of molecular and environmental bases for brain health), and Intramural Research Grant for Neurological and Psychiatric Disorders of NCNP (H.K.).
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Sasayama, D., Hori, H., Teraishi, T. et al. Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults. J Neural Transm 119, 313–318 (2012). https://doi.org/10.1007/s00702-011-0709-3
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DOI: https://doi.org/10.1007/s00702-011-0709-3