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What can Drosophila teach us about iron-accumulation neurodegenerative disorders?

  • Basic Neurosciences, Genetics and Immunology - Review Article
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Abstract

The present review focuses on the development and use of Drosophila for modeling neurodegenerative disorders that involve iron accumulation, in particular Friedrich’s Ataxia (FRDA) and Neurodegeneration with Iron accumulation (NBIA). Several Drosophila models of such disorders have been introduced successfully in the last few years. Here we review these models and note on the feasibility and advantages of using fly models for understanding the molecular and cellular bases of these devastating diseases.

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Acknowledgments

We thank R. Weiss AND M. Hanan for helpful discussions and suggestions. U.B. is funded by the Eric Roland Interdisciplinary Program in Neurodegenerative Diseases. S. K. is a recipient of a HFSP Career Development Award. The work is supported by HSFP, the Abisch-Frenkel Foundation, Fritz-Thyssen Foundation, German-Israeli Foundation Young Investigator Grant, The Legacy Found from the Israel Science Foundation and Marie Curie International Reintegration Grant (EU), to SK.

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  1. Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat-Ram, 91904, Jerusalem, Israel

    Uriya Bekenstein & Sebastian Kadener

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  1. Uriya Bekenstein
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  2. Sebastian Kadener
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Correspondence to Sebastian Kadener.

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Bekenstein, U., Kadener, S. What can Drosophila teach us about iron-accumulation neurodegenerative disorders?. J Neural Transm 118, 389–396 (2011). https://doi.org/10.1007/s00702-010-0511-7

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  • DOI: https://doi.org/10.1007/s00702-010-0511-7

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