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Early disturbances of gamma band dynamics in mild cognitive impairment

  • Dementias - Original Article
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Abstract

Recent studies have indicated that gamma band oscillations participate in the temporal binding needed for the synchronization of cortical networks involved in short-term memory and attentional processes. To date, no study has explored the temporal dynamics of gamma band in the early stages of dementia. At baseline, gamma band analysis was performed in 29 cases with mild cognitive impairment (MCI) during the n-back task. Based on phase diagrams, multiple linear regression models were built to explore the relationship between the cognitive status and gamma oscillation changes over time. Individual measures of phase diagram complexity were made using fractal dimension values. After 1 year, all cases were assessed neuropsychologically using the same battery. A total of 16 MCI patients showed progressive cognitive decline (PMCI) and 13 remained stable (SMCI). When adjusted for gamma values at lag −2, and −3 ms, PMCI cases displayed significantly lower average changes in gamma values than SMCI cases both in detection and 2-back tasks. Gamma fractal dimension of PMCI cases displayed significantly higher gamma fractal dimension values compared to SMCI cases. This variable explained 11.8% of the cognitive variability in this series. Our data indicate that the progression of cognitive decline in MCI is associated with early deficits in temporal binding that occur during the activation of selective attention processes.

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Abbreviations

EEG:

Electroencephalography

ERO:

Event-related oscillations

MCI:

Mild cognitive impairment

SMCI or PMCI:

Stable or progressive mild cognitive impairment

MMSE:

Mini-mental state examination

HAD:

Hospital anxiety and depression scale

IADL:

Lawton’s instrumental activities of daily living

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Conflict of interest statement

This study has not been submitted elsewhere for publication, in whole or in part, and all the authors listed have approved the manuscript. The authors declare that there are no actual or potential conflicts of interest. All have read and have abided by the statement of ethical standards for manuscripts submitted to this journal.

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Authors and Affiliations

  1. Clinical Neurophysiology and Neuroimaging Unit, Division of Neuropsychiatry, Department of Psychiatry, Geneva University Hospitals, University of Geneva, 2 chemin du Petit-Bel-Air, Chêne-Bourg, 1225, Geneva, Switzerland

    Pascal Missonnier

  2. Division of Geriatric Psychiatry, Department of Psychiatry, Geneva University Hospitals, University of Geneva, Geneva, Switzerland

    Pascal Missonnier, Agnès Michon & Panteleimon Giannakopoulos

  3. Department of Rehabilitation and Geriatrics, Geneva University Hospitals, University of Geneva, Geneva, Switzerland

    François R. Herrmann, Lara Fazio-Costa & Gabriel Gold

  4. Division of Old Age Psychiatry, University Hospitals of Lausanne, Prilly, Switzerland

    Panteleimon Giannakopoulos

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  1. Pascal Missonnier
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  2. François R. Herrmann
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  3. Agnès Michon
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  4. Lara Fazio-Costa
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  5. Gabriel Gold
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  6. Panteleimon Giannakopoulos
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Correspondence to Pascal Missonnier.

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P. Missonnier and F. R. Herrmann have contributed equally to this work.

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Missonnier, P., Herrmann, F.R., Michon, A. et al. Early disturbances of gamma band dynamics in mild cognitive impairment. J Neural Transm 117, 489–498 (2010). https://doi.org/10.1007/s00702-010-0384-9

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