Abstract
The purpose of this study was to test for association between Borderline personality disorder (BPD) and variants of the HTR1B and the brain-derived neurotrophic factor (BDNF) gene. We genotyped four HTR1B and the functional BDNF G196A marker in 161 Caucasian BPD patients and 156 healthy controls. There were no significant differences between groups in genotype or haplotype distribution of HTR1B markers or in genotype distribution of the BDNF marker. Logistic regression analyses revealed an over-representation of the BDNF 196A allele in HTR1B A-161 allele carrying BPD patients.
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Acknowledgments
AT received a grant from the University of Mainz (MAIFOR 2007/08). We are grateful to all participants as well as to our cooperating clinical partners (Dr. Guth and Dr. Krafczyk at the Clinic for Psychiatry in Alzey, Dr. Lehr at the Center for Social Psychiatry in Eltville) for study support. The present article is part of the doctoral thesis of Robert von Cube.
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Tadić, A., Elsäßer, A., Victor, A. et al. Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in borderline personality disorder. J Neural Transm 116, 1185–1188 (2009). https://doi.org/10.1007/s00702-009-0264-3
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DOI: https://doi.org/10.1007/s00702-009-0264-3