Abstract
Motor imagery is thought to involve the same processes of movement preparation as actual movement. Imagination of a simple repetitive movement significantly decreased the firing rate of extracellular micro recording at sensorimotor neurons of globus pallidus internus in three patients with Parkinson’s disease, who underwent microelectrode-guided posteroventral pallidotomy. These findings suggest, in agreement with previous clinical and functional neuroimaging studies that the motor corticostriatal circuit could be engaged in mental simulation.
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Boraud T, Bezard E, Bioulac B, Gross CE (2000) Ratio of inhibited-to-activated pallidal neurons decreases dramatically during passive limb movement in the MPTP-treated monkey. J Neurophysiol 83:1760–1763
Brotchie P, Lansek R, Horne M (1991) Motor functions of the monkey globus pallidus. 2 cognitive aspects of movement and phasic neuronal activity. Brain 114:1685–1702
DeLong MR (1990) Primate models of movement disorders of basal ganglia origin. Trends Neurosci 13:281–285
DeLong MR, Crutcher MD, Georgopoulos AP (1985) Primate globus pallidus and subthalamic nucleus: functional organization. J Neurophysiol 53:530–543
Dominey P, Decety J, Broussolle E, Chazot G, Jeanneroad M (1995) Motor imagery of a lateralized sequential task is asymmetrically slowed in hemi-Parkinson patients. Neuropsychologia 33:727–741
Filion M, Tremblay L (1991) Abnormal spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonism. Brain Res 547:142–151
Frak V, Cohen H, Pourcher E (2004) A dissociation between real and simulated movements in Parkinson’s disease. Neuroreport 15:1489–1492
Gerardin E, Sirigu A, Lehéricy S, Poline JB, Gaymard B, Marsault C, Agid Y, Le Bihan D (2000) Partially overlapping neural networks for real and imagined hand movements. Cereb Cortex 10:1093–1104
Hutchison WD, Lozano CA, Davis KD et al (1994) Differential neuronal activity in segments of globus pallidus in Parkinson’s disease patients. Neuroreport 5:1533–1537
Jeanneroad M (1995) Mental imagery in the motor context. Neurophysiologia 33:1419–1432
Leblois A, Boraud T, Meissner W, Bergman H, Hansel D (2006) Competition between feedback loops underlies normal and pathological dynamics in the basal ganglia. J Neurosci 26:3567–3583
Leblois A, Meissner W, Bioulac B, Gross CE, Hansel D, Boraud T (2007) Late emergence of synchronized oscillatory activity in the pallidum during progressive Parkinsonism. Eur J Neurosci 26:1701–1713
Nambu A, Yoshida S, Jinnai K (1990) Discharge patterns of pallidal neurons with inputs from various cortical areas during movement in monkeys. Brain Res 519:181–191
Person AL, Perkel DJ (2007) Pallidal neuron activity increases during sensory relay through thalamus in a songbird circuit essential for learning. J Neurosci 27:8687–8698
Sterio D, Berio A, Dogali M, Frazzini E, Alfaro G, Devinsky O (1994) Neurophysiological properties of pallidal neurons in Parkinson’s disease. Ann Neurol 35:585–591
Watts RL, Mandir AS (1992) The role of motor cortex in the pathophysiology of voluntary movement deficits associated with parkinsonism. Neurol Clin 10:451–469
Zaidel A, Moran A, Marjan G, Bergman H, Israel Z (2008) Prior pallidotomy reduces and modifies neuronal activity in the subthalamic nucleus of Parkinson’s disease patients. Eur J Neurosci 27:483–491
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Leiguarda, R., Cerquetti, D., Tenca, E. et al. Globus pallidus internus firing rate modification after motor-imagination in three Parkinson’s disease patients. J Neural Transm 116, 451–455 (2009). https://doi.org/10.1007/s00702-009-0203-3
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DOI: https://doi.org/10.1007/s00702-009-0203-3