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Evidence for the effectiveness of botulinum toxin for sialorrhoea

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Summary

Sialorrhoea is a common symptom in many neurological disorders. Recently, botulinum toxin has been introduced as a treatment for sialorrhoea, and in this paper, we review the evidence for its effectiveness. The publications on the topic were searched and reviewed independently by two authors using the scale developed by the Therapeutics and Technology Assessment subcommittee for the American Academy of Neurology. All papers identified in our search fulfilled were evaluated, and classified into 1 of the 4 levels of evidence. According to this scheme, the effectiveness of botulinum toxin A in the treatment of sialorrhoea is considered established (level A). Botulinum toxin B is considered probably effective in the treatment of sialorrhoea (level B).

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Authors and Affiliations

  1. The Parkinson’s and Movement Disorder Institute, Fountain Valley, CA, USA

    D. D. Truong & R. Bhidayasiri

  2. Movement Disorders Group, Division of Neurology, Chulalongkorn University Hospital, Bangkok, Thailand

    R. Bhidayasiri

  3. UCLA Medical Center, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    R. Bhidayasiri

Authors
  1. D. D. Truong
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  2. R. Bhidayasiri
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Correspondence to D. D. Truong.

Additional information

Correspondence: Daniel D. Truong, The Parkinson’s and Movement Disorder Institute, 9940 Talbert Ave., Fountain Valley, CA 92708, USA

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Truong, D., Bhidayasiri, R. Evidence for the effectiveness of botulinum toxin for sialorrhoea. J Neural Transm 115, 631–635 (2008). https://doi.org/10.1007/s00702-007-0861-y

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  • DOI: https://doi.org/10.1007/s00702-007-0861-y

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