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Insulin, glucose and glycated hemoglobin in Alzheimer’s and vascular dementia with and without superimposed Type II diabetes mellitus condition

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Summary.

Increased concentrations of insulin, glucose and glycohemoglobin are associated with Type II diabetes mellitus (DM) and recognized as characteristic markers of the disease; in Alzheimer’s (AD), Vascular dementia (VaD), and both dementia’s with superimposed diabetes (AD + DM, VaD + DM) the knowledge is scarce. The sample (n = 122; males = 60; mean age = 73 ± 7) comprised DM, AD, VaD, AD + DM, and VaD + DM patients, and healthy controls (C). The ANOVA’s yielded significant differences between groups: Insulin p = 3.7 × 10−3; Glucose p < 10−12; Glycohemoglobin p = 9.2×10−4. Comparisons between groups (DM vs. C, AD + DM vs. AD, VaD + DM vs. VaD, and demented DM vs. non-demented DM) resulted significant for all variables (Bonferroni’s statistic, α = 0.05). Diabetic and diabetic demented patients presented significant increases largely different from controls (0.01 < p < 0.001), unlike the non-significant changes in their non-diabetic counterparts; linear relationships were found across all groups. The correlation’s insulin/glucose and insulin/glycohemoglobin change to positive within demented groups, indicating a different performance of insulin in demented and non-demented subjects.

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Authors and Affiliations

  1. Facultad de Medicina, Hospital Sirio-Libanés, UBA, FACENE, Buenos Aires, Argentina

    R. O. Domínguez, A. L. Famulari & J. A. Serra

  2. Facultad de Ciencias Exactas y Naturales, UBA, Buenos Aires, Argentina

    E. R. Marschoff

  3. Laboratorio Especializado para las Investigaciones Clínicas (LEPLIC), Buenos Aires, Argentina

    E. M. Guareschi

  4. Facultad de Farmacia y Bioquímica, UBA, Programa de Radicales Libres (PRALIB), Buenos Aires, Argentina

    M. G. Repetto

  5. Facultad de Medicina, Hospital Juan A. Fernández, UBA, Buenos Aires, Argentina

    M. A. Pagano

Authors
  1. R. O. Domínguez
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  2. E. R. Marschoff
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  3. E. M. Guareschi
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  4. M. G. Repetto
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  5. A. L. Famulari
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  6. M. A. Pagano
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  7. J. A. Serra
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Consortia

The CGSOSRA – Collaborative Group for the Study of the Oxidative Stress and Related Abnormalities

Corresponding author

Correspondence to J. A. Serra.

Additional information

Integrated by the following medical degrees (MD) and psychologists (Ps) from the Neurology Service and the Diabetes Unit of the Hospital General de Agudos Juan A. Fernández, Hospital Sirio-Libanés and the FACENE: Eduardo L. Bartolomé MD, Silvia González MD, Graciela D’Abraccio MD, Marcela Arata Ps, Liliana Oudkerk Ps, Laura Garau MD, Fernando Krinsky MD, Edith Labos Ps, Cecilia Ruiz Ps, Gustavo Frechtel MD, Alejandra Arana MD, and Silvia Lovecchio MD.

Correspondence: Jorge A. Serra, Laboratorio de Estrés Oxidativo, PRALIB-CONICET, Facultad de Farmacia y Bioquímica, UBA; Junín 954; C1113AAD Buenos Aires, Argentina

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Domínguez, R., Marschoff, E., Guareschi, E. et al. Insulin, glucose and glycated hemoglobin in Alzheimer’s and vascular dementia with and without superimposed Type II diabetes mellitus condition. J Neural Transm 115, 77–84 (2008). https://doi.org/10.1007/s00702-007-0804-7

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  • DOI: https://doi.org/10.1007/s00702-007-0804-7

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