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Kainate receptor-mediated presynaptic inhibition converges with presynaptic inhibition mediated by Group II mGluRs and long-term depression at the hippocampal mossy fiber-CA3 synapse

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Summary

Kainate receptors (KARs) effect depression of glutamate release at hippocampal mossy fiber-CA3 (MF-CA3) synapses by a metabotropic action involving adenylyl cyclase (AC) inhibition, cAMP reduction, and diminished protein kinase A (PKA) activation. Using hippocampal slices, we show here that KAR activation interferes with the depression of glutamate release produced by Group II metabotropic glutamate receptor stimulation and low frequency stimulation (LFS)-induced long-term depression (LTD), also expressed through presynaptic AC/cAMP/PKA at MF-CA3 synapses. The mutual occlusion of depression mediated by presynaptic KARs, Group II mGluR and LFS-induced LTD suggests their mechanistic convergence at the MF-CA3 synapse and thus invokes KARs in synaptic plasticity manifest in LTD.

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Authors and Affiliations

  1. División de Neurociencias, Universidad Pablo de Olavide, Seville, Spain

    J. V. Negrete-Díaz, J. M. Delgado-García & A. Rodríguez-Moreno

  2. Department of Pharmacology, University College London, London, UK

    T. S. Sihra

Authors
  1. J. V. Negrete-Díaz
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  2. T. S. Sihra
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  3. J. M. Delgado-García
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  4. A. Rodríguez-Moreno
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Negrete-Díaz, J., Sihra, T., Delgado-García, J. et al. Kainate receptor-mediated presynaptic inhibition converges with presynaptic inhibition mediated by Group II mGluRs and long-term depression at the hippocampal mossy fiber-CA3 synapse. J Neural Transm 114, 1425–1431 (2007). https://doi.org/10.1007/s00702-007-0750-4

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  • DOI: https://doi.org/10.1007/s00702-007-0750-4

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