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Modulation of antidepressant-like activity of magnesium by serotonergic system

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Summary

The influence of magnesium on the action of antidepressants drugs with different pharmacological profiles citalopram, reboxetine and tianeptine, was investigated in the forced swim test (FST) in mice. Magnesium (10 mg Mg/kg) given with reboxetine (2.5 mg/kg) did not change the behavior of animals in the FST. A synergistic effect was seen when magnesium (10 mg Mg/kg) was given jointly with citalopram (15 mg/kg) or tianeptine (20 mg/kg) in the FST, without accompanying changes in locomotor activity. Moreover, the antidepressant-like effect of magnesium (30 mg Mg/kg) was significantly reduced by pretreatment of mice with an inhibitor of serotonin synthesis, p-chlorophenylalanine (pCPA, 200 mg/kg). Thus, the antidepressant-like action of magnesium in the FST seems to involve an interaction with serotonergic system.

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References

  • CA Altamura MC Mauri A Ferrara AR Moro G D’Andrea F Zamberlan (1993) ArticleTitlePlasma and platelet excitatory amino acids in psychiatric disorders Am J Psychiatry 150 1731–1733 Occurrence Handle1:STN:280:DyaK2c%2FislCktA%3D%3D Occurrence Handle8214185

    CAS  PubMed  Google Scholar 

  • BM Altura (1994) ArticleTitleIntroduction: importance of Mg in physiology and medicine and the need for ion selective electrodes Scand J Clin Lab Invest Suppl 217 5–9 Occurrence Handle10.3109/00365519409095206 Occurrence Handle1:STN:280:DyaK2M%2FisFKisA%3D%3D Occurrence Handle7939385

    Article  CAS  PubMed  Google Scholar 

  • CM Banki M Vojnik Z Papp KZ Balla M Arato (1985) ArticleTitleCerebrospinal fluid magnesium and calcium related to amine metabolites, diagnosis, and suicide attempts Biol Psychiatry 20 163–171 10.1016/0006-3223(85)90076-9 Occurrence Handle10.1016/0006-3223(85)90076-9 Occurrence Handle1:STN:280:DyaL2M7it12ruw%3D%3D Occurrence Handle2578829

    Article  CAS  PubMed  Google Scholar 

  • RM Berman A Cappiello A Anand DA Oren GR Heninger DS Charney JH Krystal (2000) ArticleTitleAntidepressant effect of ketamine in depressed patients Biol Psychiatry 47 351–354 10.1016/S0006-3223(99)00230-9 Occurrence Handle10.1016/S0006-3223(99)00230-9 Occurrence Handle1:CAS:528:DC%2BD3cXht1KqtrY%3D Occurrence Handle10686270

    Article  CAS  PubMed  Google Scholar 

  • JFJ Cade (1964) ArticleTitleA significant elevation of plasma magnesium levels in schizophrenia and depressive states Med J Austr 1 195–196 Occurrence Handle1:STN:280:DyaF2c%2FosVWjuw%3D%3D

    CAS  Google Scholar 

  • Cooper JR, Bloom FE, Roth RH (1996) The Biochemical Basis of Neuropharmacology. Oxford, New York

  • R Dall’Olio O Gandolgi R Gaggi (2000) ArticleTitleD-Cycloserine a positive modulator of NMDA receptors, inhibits serotonergic function Behav Pharmacol 11 631–637 Occurrence Handle11198134

    PubMed  Google Scholar 

  • JW Fawcett EJ Haxby DA Male (1999) ArticleTitleMagnesium: physiology and pharmacology Brit J Anaesth 83 302–320 Occurrence Handle1:CAS:528:DyaK1MXlslSnu70%3D Occurrence Handle10618948

    CAS  PubMed  Google Scholar 

  • A Frazer TA Ramsey A Swann C Bowden D Brunswick D Garver S Secunda (1983) ArticleTitlePlasma and erythrocyte electrolytes in affective disorders J Affect Disord 5 103–113 10.1016/0165-0327(83)90003-4 Occurrence Handle10.1016/0165-0327(83)90003-4 Occurrence Handle1:CAS:528:DyaL3sXkt1Smur8%3D Occurrence Handle6222090

    Article  CAS  PubMed  Google Scholar 

  • D Frizel A Coppen V Marks (1969) ArticleTitlePlasma magnesium and calcium in depression Br J Psychiatry 115 1375–1377 Occurrence Handle10.1192/bjp.115.529.1375 Occurrence Handle1:STN:280:DyaE3c%2FlvV2jtg%3D%3D Occurrence Handle5358528

    Article  CAS  PubMed  Google Scholar 

  • GM Hasey E D’Aleksandro RG Cooke JJ Warsh (1993) ArticleTitleThe interface between thyroid activity, magnesium, and depression: a pilot study Biol Psychiatry 33 133–135 10.1016/0006-3223(93)90314-4 Occurrence Handle10.1016/0006-3223(93)90314-4 Occurrence Handle1:CAS:528:DyaK3sXitFSltb4%3D Occurrence Handle8439603

    Article  CAS  PubMed  Google Scholar 

  • N Hashizume M Mori (1990) ArticleTitleAn analysis of hypermagnesemia and hypomagnesemia Jpn J Med 29 368–372 Occurrence Handle1:STN:280:DyaK3M7gvFSntw%3D%3D Occurrence Handle2273620

    CAS  PubMed  Google Scholar 

  • JG Henrotte G Franck M Santarromana H Frances D Mouton R Motta (1997) ArticleTitleMice selected for low and high blood magnesium levels: a new model of stress studies Physiol Behav 61 653–658 10.1016/S0031-9384(96)00506-9 Occurrence Handle10.1016/S0031-9384(96)00506-9 Occurrence Handle1:CAS:528:DyaK2sXjtVGnsr0%3D Occurrence Handle9145932

    Article  CAS  PubMed  Google Scholar 

  • J Hyttel (1994) ArticleTitlePharmacological characterization of selective serotonin reuptake inhibitors (SSRIs) Int Clin Psychopharmacol 9 IssueIDSuppl 1 19–26 Occurrence Handle8021435 Occurrence Handle10.1097/00004850-199403001-00004

    Article  PubMed  Google Scholar 

  • K Kamei O Tabata SI Muneoka R Tomiyoshi M Takigawa (1988) ArticleTitleElectrolytes in erythrocytes of patients with depressive disorders Psychiat Clin Neurosci 52 529–533 10.1046/j.1440-1819.1998.00426.x Occurrence Handle10.1046/j.1440-1819.1998.00426.x

    Article  Google Scholar 

  • KM Kantak (1988) ArticleTitleMagnesium deficiency alters aggressive behavior and catecholamine function Behav Neurosci 102 304–311 10.1037/0735-7044.102.2.304 Occurrence Handle10.1037/0735-7044.102.2.304 Occurrence Handle1:CAS:528:DyaL1cXkt1ajs7k%3D Occurrence Handle3365326

    Article  CAS  PubMed  Google Scholar 

  • S Kasper JP Olie (2002) ArticleTitleA meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression Eur Psychiatry 17 331–340 10.1016/S0924-9338(02)00651-X Occurrence Handle10.1016/S0924-9338(02)00651-X Occurrence Handle15177089

    Article  PubMed  Google Scholar 

  • MB Keller (2000) ArticleTitleCitalopram therapy of depression: a review of 10 years of European experience and data from U.S. clinical trials J Clin Psychiatry 61 896–908 Occurrence Handle1:CAS:528:DC%2BD3MXhtVChtrw%3D Occurrence Handle11206593 Occurrence Handle10.4088/JCP.v61n1202

    Article  CAS  PubMed  Google Scholar 

  • DK Kirov NJ Birch P Steadman RG Ramsey (1994) ArticleTitlePlasma magnesium levels in a populations of psychiatric patients: correlations with symptoms Neurobiology 30 73–78 Occurrence Handle1:STN:280:DyaK2M%2FpvVaksg%3D%3D

    CAS  Google Scholar 

  • BK Koe A Weissmen (1966) ArticleTitlep-Chlorophenylalanine: a specific depletory of brain serotonin J Pharmacol Exp Ther 154 499–516 Occurrence Handle1:CAS:528:DyaF2sXpvVSj Occurrence Handle5297133

    CAS  PubMed  Google Scholar 

  • MHP Kole L Swan E Fuchs (2002) ArticleTitleThe antidepressant tianeptine persistently modulates glutamate receptor currents of the hippocampal CA3 commissural associational synapse in chronically stressed rats Eur J Neurosci 16 807–816 10.1046/j.1460-9568.2002.02136.x Occurrence Handle10.1046/j.1460-9568.2002.02136.x Occurrence Handle12372016

    Article  PubMed  Google Scholar 

  • AJ Law JF Deakin (2001) ArticleTitleAsymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychosis Neuroreport 12 2971–2974 10.1097/00001756-200109170-00043 Occurrence Handle10.1097/00001756-200109170-00043 Occurrence Handle1:CAS:528:DC%2BD3MXnsFSlt74%3D Occurrence Handle11588613

    Article  CAS  PubMed  Google Scholar 

  • J Levine K Panchalingam A Rapoport S Gershon RJ McClure JW Pettegrew (2000) ArticleTitleIncreased cerebrospinal fluid glutamine levels in depressed patients Biol Psychiatry 47 586–593 10.1016/S0006-3223(99)00284-X Occurrence Handle10.1016/S0006-3223(99)00284-X Occurrence Handle1:CAS:528:DC%2BD3cXitVSku7s%3D Occurrence Handle10745050

    Article  CAS  PubMed  Google Scholar 

  • J Linder K Brismar J Beck-Friis J Sääf L Wetterberg (1989) ArticleTitleCalcium and magnesium concentrations in affective disorder: difference between plasma and serum in relation to symptoms Acta Psychiatry Scand 80 527–537 Occurrence Handle10.1111/j.1600-0447.1989.tb03021.x Occurrence Handle1:STN:280:DyaK3c7ksVShuw%3D%3D

    Article  CAS  Google Scholar 

  • W Löscher R Annies D Hönack (1991) ArticleTitleThe N-methyl-D-aspartate receptor antagonist MK-801 induces increases in dopamine and serotonin metabolism in several brain regions Neurosci Lett 128 191–194 10.1016/0304-3940(91)90258-U Occurrence Handle10.1016/0304-3940(91)90258-U Occurrence Handle1834964

    Article  PubMed  Google Scholar 

  • W Löscher R Annies D Hönack (1993) ArticleTitleComparison of competitive and uncompetitive NMDA receptor antagonists with regard to monoaminergic neuronal activity and behavioral effects in rats Eur J Pharmacol 242 263–274 10.1016/0014-2999(93)90250-L Occurrence Handle10.1016/0014-2999(93)90250-L Occurrence Handle7904243

    Article  PubMed  Google Scholar 

  • J Maj Z Rogóż G Skuza H Sowińska (1992) ArticleTitleEffects of MK-801 and antidepressant drugs in the forced swimming test in rats Eur Neuropsychopharm 2 37–41 10.1016/0924-977X(92)90034-6 Occurrence Handle10.1016/0924-977X(92)90034-6 Occurrence Handle1:CAS:528:DyaK38XmtVGjtLg%3D

    Article  CAS  Google Scholar 

  • P Martin ML Carlson S Hjorth (1988) ArticleTitleSystemic PCP treatment elevates brain extracellular 5-HT: a microdialysis study in awake rats Neuroreport 9 2985–2988 Occurrence Handle10.1097/00001756-199809140-00012

    Article  Google Scholar 

  • R Mathis L Schmitt M Benatia F Granier J Ghisolfi P Moron (1988) ArticleTitlePlasma amino acid disturbances and depression Encephale 14 77–82 Occurrence Handle1:CAS:528:DyaL1cXkslWmsr8%3D Occurrence Handle3391131

    CAS  PubMed  Google Scholar 

  • BS McEwen AM Magarinos LP Reagan (2002) ArticleTitleStructural plasticy and tianeptine: cellular and molecular targets Eur Psychiatry 17 318–330 10.1016/S0924-9338(02)00650-8 Occurrence Handle10.1016/S0924-9338(02)00650-8 Occurrence Handle15177088

    Article  PubMed  Google Scholar 

  • E Mocaer MC Rettori A Kamoun (1988) ArticleTitlePharmacological antidepressive effects and tianeptine-induced 5-HT uptake increase Clinl Neuropharmacol 11 32–42

    Google Scholar 

  • H Mori H Masaki T Yamakura M Mishina (1992) ArticleTitleIdentification by mutagenesis of a Mg2+ — block site of the NMDA receptor channel Nature 358 673–675 10.1038/358673a0 Occurrence Handle10.1038/358673a0 Occurrence Handle1:CAS:528:DyaK38XlsVCisLg%3D Occurrence Handle1386653

    Article  CAS  PubMed  Google Scholar 

  • H Murck (2002) ArticleTitleMagnesium and affective disorders Nutr Neurosci 5 375–389 10.1080/1028415021000039194 Occurrence Handle10.1080/1028415021000039194 Occurrence Handle1:CAS:528:DC%2BD3sXovFWisg%3D%3D Occurrence Handle12509067

    Article  CAS  PubMed  Google Scholar 

  • G Nowak B Szewczyk (2002) ArticleTitleMechanisms contributing to antidepressant zinc action Pol J Pharmacol 54 587–592 Occurrence Handle1:CAS:528:DC%2BD3sXit1yhsrs%3D Occurrence Handle12866713

    CAS  PubMed  Google Scholar 

  • G Nowak R Trullas RT Layer P Skolnick IA Paul (1993) ArticleTitleAdaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-amino-cyclopropnecarboxylic acid J Pharmacol Exp Ther 265 1380–1386 Occurrence Handle1:CAS:528:DyaK3sXltVyru7c%3D Occurrence Handle8099620

    CAS  PubMed  Google Scholar 

  • G Nowak GA Ordway IA Paul (1995) ArticleTitleAlterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims Brain Res 675 157–164 10.1016/0006-8993(95)00057-W Occurrence Handle10.1016/0006-8993(95)00057-W Occurrence Handle1:CAS:528:DyaK2MXksVylu70%3D Occurrence Handle7796124

    Article  CAS  PubMed  Google Scholar 

  • G Nowak B Legutko P Skolnick P Popik (1998) ArticleTitleAdaptation of cortical NMDA receptors by chronic treatment with specific serotonin reuptake inhibitors Eur J Pharmacol 342 367–370 10.1016/S0014-2999(97)01589-6 Occurrence Handle10.1016/S0014-2999(97)01589-6 Occurrence Handle1:CAS:528:DyaK1cXhvFKktLs%3D Occurrence Handle9548410

    Article  CAS  PubMed  Google Scholar 

  • G Nowak B Szewczyk A Pilc (2005) ArticleTitleZinc and depression. An update Pharmacol Rep 57 713–718 Occurrence Handle1:CAS:528:DC%2BD28XjtlCksrg%3D Occurrence Handle16382189

    CAS  PubMed  Google Scholar 

  • E Poleszak G Nowak (2006) ArticleTitleMagnesium in pathophysiology and therapy of affective disorders J Elementol 11 389–397

    Google Scholar 

  • E Poleszak B Szewczyk E Kędzierska P Wlaź A Pilc G Nowak (2004) ArticleTitleAntidepressant-like activity of magnesium in mice Pharm Biochem Behav 78 7–12 10.1016/j.pbb.2004.01.006 Occurrence Handle10.1016/j.pbb.2004.01.006 Occurrence Handle1:CAS:528:DC%2BD2cXkt1Srs7k%3D

    Article  CAS  Google Scholar 

  • E Poleszak P Wlaź B Szewczyk E Kędzierska E Wyska T Librowdki J Szymura-Oleksiak S Fidecka A Pilc G Nowak (2005a) ArticleTitleEnhancement of antidepressant-like activity by joint administration if imipramine and magnesium in the forced swim test: behavioral and pharmacokinetic studies in mice Pharm Biochem Behav 81 524–529 10.1016/j.pbb.2005.03.017 Occurrence Handle10.1016/j.pbb.2005.03.017 Occurrence Handle1:CAS:528:DC%2BD2MXmt1arsbk%3D

    Article  CAS  Google Scholar 

  • E Poleszak P Wlaź E Kędzierska M Radziwon-Zaleska A Pilc S Fidecka G Nowak (2005b) ArticleTitleEffects of acute and chronic treatment with magnesium in the forced swim test in rats Pharmacol Rep 57 654–658 Occurrence Handle1:CAS:528:DC%2BD28XktVCmuw%3D%3D

    CAS  Google Scholar 

  • HH Rasmussen PB Mortensen IW Jensen (1989) ArticleTitleDepression and magnesium deficiency Int J Psychiat Med 19 57–63 Occurrence Handle1:STN:280:DyaL1M3lsVartw%3D%3D Occurrence Handle10.2190/NKCD-1RB1-QMA9-G1VN

    Article  CAS  Google Scholar 

  • N Singewald C Sinner A Hetzenauer SB Saroti H Murck (2004) ArticleTitleMagnesium-deficient diet alters depressio- and anxiety-related behavior in mice — influence of desipramine and Hypericum perforatum extract Neuropharmacology 47 1189–1197 Occurrence Handle1:CAS:528:DC%2BD2cXhtVahurfK Occurrence Handle15567428

    CAS  PubMed  Google Scholar 

  • P Skolnick (1999) ArticleTitleAntidepressants for the new millennium Eur J Pharmacol 375 31–40 10.1016/S0014-2999(99)00330-1 Occurrence Handle10.1016/S0014-2999(99)00330-1 Occurrence Handle1:CAS:528:DyaK1MXks1Cku7c%3D Occurrence Handle10443562

    Article  CAS  PubMed  Google Scholar 

  • P Skolnick RT Layer P Popik G Nowak IA Paul R Trullas (1996) ArticleTitleAdaptation of N-methyl-D-aspartate receptors following antidepressant treatment: implications for the pharmacotherapy of depression Pharmacopsychiatry 29 23–26 10.1055/s-2007-979537 Occurrence Handle10.1055/s-2007-979537 Occurrence Handle1:CAS:528:DyaK2sXjs1Cgu7Y%3D Occurrence Handle8852530

    Article  CAS  PubMed  Google Scholar 

  • P Skolnick B Legutko X Li FP Bymaster (2001) ArticleTitleCurrent perspectives on the development of non-biogenic amine-based antidepressants Pharmacol Res 43 411–422 10.1006/phrs.2000.0806 Occurrence Handle10.1006/phrs.2000.0806 Occurrence Handle1:CAS:528:DC%2BD3MXktFWhtbg%3D Occurrence Handle11394932

    Article  CAS  PubMed  Google Scholar 

  • R Trullas P Skolnick (1990) ArticleTitleFunctional antagonists at the NMDA receptor complex exhibit antidepressant action Eur J Pharmacol 185 1–10 10.1016/0014-2999(90)90204-J Occurrence Handle10.1016/0014-2999(90)90204-J Occurrence Handle1:CAS:528:DyaK3cXls1Gqtbk%3D Occurrence Handle2171955

    Article  CAS  PubMed  Google Scholar 

  • M Versiani L Mehilane P Gaszner R Arnaud-Castiglioni (1999) ArticleTitleReboxetine, a unique selective NRI, prevent relapse and recurrence in long-term treatment of major depressive disorder J Clin Psychiatry 60 400–406 Occurrence Handle1:CAS:528:DyaK1MXktlegsbw%3D Occurrence Handle10401920

    CAS  PubMed  Google Scholar 

  • AJ Wagstaff D Ormrod CM Spencer (2001) ArticleTitleTianptine: a review of its use in depressive disorders CNS Drugs 15 231–259 10.2165/00023210-200115030-00006 Occurrence Handle10.2165/00023210-200115030-00006 Occurrence Handle1:CAS:528:DC%2BD3MXislyktb0%3D Occurrence Handle11463130

    Article  CAS  PubMed  Google Scholar 

  • K Wędzony M Mackowiak A Czyrak K Fijal B Michalska (1997) ArticleTitleSingle doses of MK-801, a non-competitive antagonist of NMDA receptors, increase the number of 5-HT1A serotonin receptors in the rat brain Brain Res 756 84–91 10.1016/S0006-8993(97)00159-5 Occurrence Handle10.1016/S0006-8993(97)00159-5 Occurrence Handle9187317

    Article  PubMed  Google Scholar 

  • J Widmer P Bovier F Karege Y Raffin H Hildret JM Gaillard R Tissot (1992) ArticleTitleEvolution of blood magnesium, sodium and potassium in depressed patients followed for three months Neuropsychpharmacology 26 173–179 Occurrence Handle1:STN:280:DyaK3s3jtl2ksA%3D%3D

    CAS  Google Scholar 

  • J Widmer N Stella Y Raffin P Bovier JM Gaillard H Hillert R Tissot (1993) ArticleTitleBlood magnesium, potassium, sodium, calcium and cortisol in drug-free depressed patients Magnesium Res 6 33–41 Occurrence Handle1:STN:280:DyaK3sznvVyhuw%3D%3D

    CAS  Google Scholar 

  • J Widmer JG Henrotte Y Raffin P Bovier H Hillert JM Gaillard (1995) ArticleTitleRelationship between erythrocyte magnesium, plasma electrolytes and cortisol and intensity of symptoms in major depressed patients J Affect Disord 34 201–209 10.1016/0165-0327(95)00018-I Occurrence Handle10.1016/0165-0327(95)00018-I Occurrence Handle1:STN:280:DyaK28%2FktVSmsw%3D%3D Occurrence Handle7560548

    Article  CAS  PubMed  Google Scholar 

  • Q Yan MEA Reith PC Jobe JW Dailey (1997) ArticleTitleDizocilpine (MK-801) increases not only dopamine but also serotonin and norepinephrine transmissions in the nucleus accumbens as measured by microdialysis in freely moving rats Brain Res 765 149–158 10.1016/S0006-8993(97)00568-4 Occurrence Handle10.1016/S0006-8993(97)00568-4 Occurrence Handle1:CAS:528:DyaK2sXksFamu78%3D Occurrence Handle9310406

    Article  CAS  PubMed  Google Scholar 

  • LT Young JC Robb AJ Levitt RG Cooke RT Joffe (1996) ArticleTitleSerum Mg2 and Ca2/Mg2 ratio in major depressive disorder Neuropsychobiology 34 26–28 10.1159/000119287 Occurrence Handle10.1159/000119287 Occurrence Handle1:CAS:528:DyaK28Xmtl2ju78%3D Occurrence Handle8884756

    Article  CAS  PubMed  Google Scholar 

  • CA Zarate SuffixJr JB Singh PJ Carlson NE Brutsche R Ameli DA Luckenbaugh DS Charney HK Manji (2006) ArticleTitleA randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression Arch Gen Psychiatry 63 856–864 10.1001/archpsyc.63.8.856 Occurrence Handle10.1001/archpsyc.63.8.856 Occurrence Handle1:CAS:528:DC%2BD28XovF2lsLo%3D Occurrence Handle16894061

    Article  CAS  PubMed  Google Scholar 

  • A Zięba R Kata D Dudek M Schlegel-Zawadzka G Nowak (2000) ArticleTitleSerum Trace Elements in Animal Models and Human Depression: Part III. Magnesium. Relationship with copper Hum Psychopharm Clin 15 631–635 10.1002/hup.231 Occurrence Handle10.1002/hup.231

    Article  Google Scholar 

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  1. Department of Pharmacology and Pharmacodynamics, Skubiszewski Medical University of Lublin, Lublin, Poland

    E. Poleszak

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Poleszak, E. Modulation of antidepressant-like activity of magnesium by serotonergic system. J Neural Transm 114, 1129–1134 (2007). https://doi.org/10.1007/s00702-007-0714-8

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