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Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression

Summary

Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. We attempt to show that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression. The sample consists of 119 patients with treatment-resistant MDD and 392 controls. 5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.

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Anttila, S., Huuhka, K., Huuhka, M. et al. Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression. J Neural Transm 114, 1065–1068 (2007). https://doi.org/10.1007/s00702-007-0705-9

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  • DOI: https://doi.org/10.1007/s00702-007-0705-9

  • Keywords: 5-HT1A, BDNF, polymorphism, major depression, treatment-resistant, electroconvulsive therapy