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Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression

Journal of Neural Transmission volume 114, pages 1065–1068 (2007)Cite this article

Summary

Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. We attempt to show that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression. The sample consists of 119 patients with treatment-resistant MDD and 392 controls. 5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.

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Authors and Affiliations

  1. Medical School, University of Tampere, Tampere, Finland

    S. Anttila, K. Huuhka, M. Huuhka, R. Rontu, E. Leinonen & T. Lehtimäki

  2. Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland

    S. Anttila, R. Rontu & T. Lehtimäki

  3. Department of Psychiatry, Tampere University Hospital, Pitkäniemi, Finland

    K. Huuhka, M. Huuhka & E. Leinonen

  4. Department of Microbiology and Immunology, Medical School, University of Tampere, Tampere, Finland

    M. Hurme

  5. The Laboratory Centre, Tampere University Hospital, Tampere, Finland

    M. Hurme

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  1. S. Anttila
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  2. K. Huuhka
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  3. M. Huuhka
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  4. R. Rontu
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  5. M. Hurme
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  6. E. Leinonen
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  7. T. Lehtimäki
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Anttila, S., Huuhka, K., Huuhka, M. et al. Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression. J Neural Transm 114, 1065–1068 (2007). https://doi.org/10.1007/s00702-007-0705-9

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  • DOI: https://doi.org/10.1007/s00702-007-0705-9

  • Keywords: 5-HT1A, BDNF, polymorphism, major depression, treatment-resistant, electroconvulsive therapy