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Alteration of serum semicarbazide-sensitive amine oxidase activity in chronic renal failure

  • Amine oxidases and disease
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Summary

Despite recent intensive investigations, physiological and pathological role of semicarbazide-sensitive amine oxidase (SSAO) is far from clear. In this study, serum SSAO activity was determined, radiochemically, in various groups of uremic patients: haemodialysed (HD), peritoneally dialysed (PD) and those receiving conservative treatment but still not dialysed (ND), as well as in controls. Reduced enzyme activity was found in HD uremic patients before and after dialysis treatment, compared to controls (5260 ± 862 and 6011 ± 958 pmol/h/ml vs. 8601 ± 283 pmol/h/ml, p < 0.01 and p < 0.05, respectively). The activity was slightly lower in PD, and normal in ND patients. In HD patients SSAO activity was also determined by an assay based on the formation of hydrogen peroxide, and was found to be elevated compared to controls (2384 ± 323 pmol/h/ml vs. 1437 ± 72 pmol/h/ml, p < 0.05). The elevated serum SSAO activity measured through the detection of the enzyme-generated hydrogen peroxide in HD patients might indicate its contribution to the accelerated atherosclerotic disease observed in uremia.

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Abbreviations

HD:

haemodialysed

MA:

methylamine

ND:

not dialysed

PD:

peritoneally dialysed

SSAO:

semicarbazide-sensitive amine oxidase

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Authors and Affiliations

  1. Angiology and Nephrology Division, Institute of Internal Medicine, St. Imre Teaching Hospital, Budapest, Hungary

    J. Nemcsik, L. Toth, J. Egresits & I. Kiss

  2. Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary

    É. Szökö, Zs. Soltész, T. Tábi & K. Magyar

  3. 1st Department of Eurocare Dialysis Centers, Budapest, Hungary

    E. Fodor

Authors
  1. J. Nemcsik
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  2. É. Szökö
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  3. Zs. Soltész
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  4. E. Fodor
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  5. L. Toth
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  6. J. Egresits
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  7. T. Tábi
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  8. K. Magyar
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  9. I. Kiss
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Nemcsik, J., Szökö, É., Soltész, Z. et al. Alteration of serum semicarbazide-sensitive amine oxidase activity in chronic renal failure. J Neural Transm 114, 841–843 (2007). https://doi.org/10.1007/s00702-007-0698-4

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  • DOI: https://doi.org/10.1007/s00702-007-0698-4

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