Skip to main content

Advertisement

SpringerLink
Log in

Effect of aldehydes derived from oxidative deamination and oxidative stress on β-amyloid aggregation; pathological implications to Alzheimer’s disease

  • Amine oxidases and disease
  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary

Formaldehyde and methylglyoxal are generated via deamination from methylamine and aminoacetone respectively catalyzed by semicarbazide-sensitive amine oxidase (SSAO). Malondialdehyde (MDA) and 4-hydroxynonenal (HNE) are end products of lipid peroxidation due to oxidative stress. These aldehydes are capable of inducing protein cross-linkage. Elevated levels of aldehydes were found in Alzheimer’s disease (AD). These reactive metabolites may potentially play important roles in β-amyloid (Aβ) aggregation related to the pathology of AD. In the present study thioflavin-T (ThT) fluorometry, an immuno-dot-blot assay and atomic force microscopy (AFM) were employed to reveal the effect of aldehydes on Aβ aggregation in vitro. The target on Aβ for interaction with formaldehyde was identified. The results support the involvement of endogenous aldehydes in amyloid deposition related to AD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • F Boomsma PJ de Kam G Tjeerdsma et al. (2000) ArticleTitlePlasma semicarbazide-sensitive amine oxidase (SSAO) is an independent prognostic marker for mortality in chronic heart failure Eur Heart J 21 1859–1863 10.1053/euhj.2000.2176 Occurrence Handle10.1053/euhj.2000.2176 Occurrence Handle1:CAS:528:DC%2BD3cXos1Ogurw%3D Occurrence Handle11052858

    Article  CAS  PubMed  Google Scholar 

  • F Coria F Prelli EM Castano et al. (1988) ArticleTitleBeta-protein deposition: a pathogenetic link between Alzheimer’s disease and cerebral amyloid angiopathies Brain Res 463 187–191 10.1016/0006-8993(88)90545-8 Occurrence Handle10.1016/0006-8993(88)90545-8 Occurrence Handle1:CAS:528:DyaL1MXjslelsA%3D%3D Occurrence Handle3058268

    Article  CAS  PubMed  Google Scholar 

  • R Dei A Takeda H Niwa M Li Y Nakagomi M Watanabe T Inagaki Y Washimi Y Yasuda K Horie T Miyata G Sobue (2002) ArticleTitleLipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer’s disease Acta Neuropathol (Berl) 104 113–122 10.1007/s00401-002-0523-y Occurrence Handle10.1007/s00401-002-0523-y Occurrence Handle1:CAS:528:DC%2BD38XkvFKqsbw%3D

    Article  CAS  Google Scholar 

  • M del Mar Hernandez M Esteban P Szabo M Boada M Unzeta (2005) ArticleTitleHuman plasma semicarbazide sensitive amine oxidase (SSAO), beta-amyloid protein and aging Neurosci Lett 384 183–187 10.1016/j.neulet.2005.04.074 Occurrence Handle10.1016/j.neulet.2005.04.074 Occurrence Handle15894424 Occurrence Handle1:CAS:528:DC%2BD2MXlt1Kitb0%3D

    Article  PubMed  CAS  Google Scholar 

  • M Dib C Garrel A Favier V Robin C Desnuelle (2002) ArticleTitleCan malondialdehyde be used as a biological marker of progression in neurodegenerative disease? J Neurol 249 367–374 10.1007/s004150200025 Occurrence Handle10.1007/s004150200025 Occurrence Handle1:CAS:528:DC%2BD38XksVGlsLg%3D Occurrence Handle11967639

    Article  CAS  PubMed  Google Scholar 

  • I Ferrer JM Lizcano M Hernandez M Unzeta (2002) ArticleTitleOverexpression of semicarbazide sensitive amine oxidase in the cerebral blood vessels in patients with Alzheimer’s disease and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy Neurosci Lett 321 21–24 10.1016/S0304-3940(01)02465-X Occurrence Handle10.1016/S0304-3940(01)02465-X Occurrence Handle1:CAS:528:DC%2BD38XhsFWgtLk%3D Occurrence Handle11872247

    Article  CAS  PubMed  Google Scholar 

  • D Gubisne-Haberle W Hill M Kazachkov JS Richardson PH Yu (2004) ArticleTitleProtein cross-linkage induced by formaldehyde derived from semicarbazide-sensitive amine oxidase-mediated deamination of methylamine J Pharmacol Exp Therap 310 1125–1132 10.1124/jpet.104.068601 Occurrence Handle10.1124/jpet.104.068601 Occurrence Handle1:CAS:528:DC%2BD2cXnt1eqtbc%3D

    Article  CAS  Google Scholar 

  • KA Jellinger (2002) ArticleTitleAlzheimer disease and cerebrovascular pathology: an update J Neural Trans 109 813–836 10.1007/s007020200068 Occurrence Handle10.1007/s007020200068 Occurrence Handle1:STN:280:DC%2BD38zmt1SitA%3D%3D

    Article  CAS  Google Scholar 

  • M Kawai RN Kalaria P Cras SL Siedlak ME Velasco ER Shelton HW Chan BD Greenberg G Perry (1993) ArticleTitleDegeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease Brain Res 623 142–146 10.1016/0006-8993(93)90021-E Occurrence Handle10.1016/0006-8993(93)90021-E Occurrence Handle1:CAS:528:DyaK3sXmt1egtLs%3D Occurrence Handle8221082

    Article  CAS  PubMed  Google Scholar 

  • R Kayed E Head JL Thompson TM McIntire SC Milton CW Cotman CG Glabe (2003) ArticleTitleCommon structure of soluble amyloid oligomers implies common mechanism of pathogenesis Science 300 486–489 10.1126/science.1079469 Occurrence Handle10.1126/science.1079469 Occurrence Handle1:CAS:528:DC%2BD3sXivFyms7k%3D Occurrence Handle12702875

    Article  CAS  PubMed  Google Scholar 

  • M Kazachkov PH Yu (2005) ArticleTitleA novel HPLC procedure for detection and quantification of aminoacetone, a precursor of methylglyoxal, in biological samples J Chromatogr B 824 116–112 Occurrence Handle10.1016/j.jchromb.2005.07.006 Occurrence Handle1:CAS:528:DC%2BD2MXpslynsb0%3D

    Article  CAS  Google Scholar 

  • WL Klein WB Stine SuffixJr DB Teplow (2004) ArticleTitleSmall assemblies of unmodified amyloid-protein are the proximate neurotoxin in Alzheimer’s disease Neurobiol Aging 25 569–580 10.1016/j.neurobiolaging.2004.02.010 Occurrence Handle10.1016/j.neurobiolaging.2004.02.010 Occurrence Handle1:CAS:528:DC%2BD2cXksVGgt7o%3D Occurrence Handle15172732

    Article  CAS  PubMed  Google Scholar 

  • B Kuhla HJ Luth D Haferburg K Boeck T Arendt G Munch (2005) ArticleTitleMethylglyoxal, glyoxal, and their detoxification in Alzheimer’s disease Ann NY Acad Sci 1043 211–216 10.1196/annals.1333.026 Occurrence Handle10.1196/annals.1333.026 Occurrence Handle1:CAS:528:DC%2BD2MXpvVKqsb8%3D Occurrence Handle16037241

    Article  CAS  PubMed  Google Scholar 

  • DT Loo A Copani CJ Pike ER Whittemore AJ Walencewizcz CW Cotman (1993) ArticleTitleApoptosis is induced by β-amyloid in cultured central nervous system neurons Proc Natl Acad Sci USA 90 7951–7955 10.1073/pnas.90.17.7951 Occurrence Handle10.1073/pnas.90.17.7951 Occurrence Handle1:CAS:528:DyaK3sXmtVWis7Y%3D Occurrence Handle8367446

    Article  CAS  PubMed  Google Scholar 

  • JA Luchsinger MX Tang Y Stern S Shea R Mayeux (2001) ArticleTitleDiabetes mellitus and risk of Alzheimer’s disease and dementia with stroke in a multiethnic cohort Am J Epidemiol 154 635–641 10.1093/aje/154.7.635 Occurrence Handle10.1093/aje/154.7.635 Occurrence Handle1:STN:280:DC%2BD3MrjvVKnsA%3D%3D Occurrence Handle11581097

    Article  CAS  PubMed  Google Scholar 

  • J Ma A Yee HB Brewer SuffixJr S Das H Potter (1994) ArticleTitleAmyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments Nature 372 92–94 10.1038/372092a0 Occurrence Handle10.1038/372092a0 Occurrence Handle1:CAS:528:DyaK2cXmvFygur0%3D Occurrence Handle7969426

    Article  CAS  PubMed  Google Scholar 

  • LT McGrath BM McGleenon S Brennan D McColl S McILroy AP Passmore (2001) ArticleTitleIncreased oxidative stress in Alzheimer-disease as assessed with 4-hydroxynonenal but not malondialdehyde Q J Med 94 485–490 Occurrence Handle1:STN:280:DC%2BD3Mvos1agtw%3D%3D

    CAS  Google Scholar 

  • C Messier (2003) ArticleTitleDiabetes, Alzheimer’s disease and apolipoprotein genotype Exp Gerontol 38 941–946 10.1016/S0531-5565(03)00153-0 Occurrence Handle10.1016/S0531-5565(03)00153-0 Occurrence Handle1:CAS:528:DC%2BD3sXmvVygtrs%3D Occurrence Handle12954480

    Article  CAS  PubMed  Google Scholar 

  • AE Roher JD Lowenson S Clarke AS Woods RJ Cotter E Gowing MJ Ball (1993) ArticleTitlebeta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease Proc Natl Acad Sci USA 90 10836–10840 10.1073/pnas.90.22.10836 Occurrence Handle10.1073/pnas.90.22.10836 Occurrence Handle1:CAS:528:DyaK2cXltFOjtQ%3D%3D Occurrence Handle8248178

    Article  CAS  PubMed  Google Scholar 

  • LM Sayre DA Zelasko PL Harris G Perry RG Salomon MA Smith (1997) ArticleTitle4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer’s disease J Neurochem 68 2092–2097 Occurrence Handle1:CAS:528:DyaK2sXivVSisbw%3D Occurrence Handle9109537 Occurrence Handle10.1046/j.1471-4159.1997.68052092.x

    Article  CAS  PubMed  Google Scholar 

  • DJ Selkoe (2002) ArticleTitleAlzheimer’s disease: genes, protein and therapy Physiol Rev 81 741–766

    Google Scholar 

  • L Stanyer DJ Betteridge CC Smith (2004) ArticleTitleExaggerated polymerisation of beta-amyloid 40 stimulated by plasma lipoproteins results in fibrillar Abeta preparations that are ineffective in promoting ADP-induced platelet aggregation Biochim Biophys Acta 1674 305–311 Occurrence Handle1:CAS:528:DC%2BD2cXpvVygur4%3D Occurrence Handle15541300

    CAS  PubMed  Google Scholar 

  • KV Subbarao JS Richardson LC Ang (1990) ArticleTitleAutopsy samples of Alzheimer’s cortex show increased peroxidation in vitro J Neurochem 55 342–345 10.1111/j.1471-4159.1990.tb08858.x Occurrence Handle10.1111/j.1471-4159.1990.tb08858.x Occurrence Handle1:CAS:528:DyaK3cXksFKrs78%3D Occurrence Handle2355227

    Article  CAS  PubMed  Google Scholar 

  • PJ Thornalley (2002) ArticleTitleGlycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic options Int Rev Neurobiol 50 37–57 10.1016/S0074-7742(02)50072-6 Occurrence Handle10.1016/S0074-7742(02)50072-6 Occurrence Handle1:CAS:528:DC%2BD38XotFaqur8%3D Occurrence Handle12198817

    Article  CAS  PubMed  Google Scholar 

  • PH Yu YL Deng (1998) ArticleTitleEndogenous formaldehyde as a potential factor of vulnerability of atherosclerosis: Involvement of semicarbazide-sensitive amine oxidase-mediated methylamine turnover Atherosclerosis 140 357–363 10.1016/S0021-9150(98)00142-7 Occurrence Handle10.1016/S0021-9150(98)00142-7 Occurrence Handle1:CAS:528:DyaK1cXms1Srsbo%3D Occurrence Handle9862279

    Article  CAS  PubMed  Google Scholar 

  • PH Yu S Wright EH Fan ZR Lun D Gubisne-Haberle (2003) ArticleTitlePhysiological and pathological implications of semicarbazide-sensitive amine oxidase Biochim Biophys Acta 1647 193–199 Occurrence Handle1:CAS:528:DC%2BD3sXislCisrY%3D Occurrence Handle12686132

    CAS  PubMed  Google Scholar 

  • PH Yu DM Zuo (1993) ArticleTitleOxidative deamination of methylamine by semicarbazide-sensitive amine oxidase leads to cytotoxic damage in endothelial cells; Possible consequence for diabetes Diabetes 42 594–603 10.2337/diabetes.42.4.594 Occurrence Handle10.2337/diabetes.42.4.594 Occurrence Handle1:CAS:528:DyaK3sXktVKhu7Y%3D Occurrence Handle8454111

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    K. Chen, M. Kazachkov & P. H. Yu

Authors
  1. K. Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Kazachkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. H. Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, K., Kazachkov, M. & Yu, P. Effect of aldehydes derived from oxidative deamination and oxidative stress on β-amyloid aggregation; pathological implications to Alzheimer’s disease. J Neural Transm 114, 835–839 (2007). https://doi.org/10.1007/s00702-007-0697-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00702-007-0697-5

Search

Navigation