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RETRACTED ARTICLE: Monoallelic expression of MAO-A in skin fibroblasts

  • Amine oxidase structure and function
  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

This article was retracted on 26 August 2009

Summary

X chromosome inactivation in mammalian females occurs early in embryonic development and renders most genes on the inactive X chromosome transcriptionally silenced. As a consequence, females will display an X chromosomal parent-of-origin mosaicism with regard to which parental allele that is expressed. Some genes however, escape inactivation and will therefore be expressed from both alleles. In this study we have investigated if the X-linked MAO-A gene have bi- or mono-allelic expression. This information would indicate whether or not MAO-A gene dosage could potentially explain the observed gender differences that show functional connections to the serotonin system, such as aggression and impulsiveness. To investigate the X inactivation status of MAO-A we have used primary clonal cell cultures, on which allelic expression was assessed with RFLP analysis. Our results show that the MAO-A gene has mono-allelic expression in these cells. This could have important implications for understanding traits that display gender differences.

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References

  • B Af Klinteberg L von Knorring L Oreland (2004) On the psychobiology of impulsivity: On the psychobiology of personality R Mack (Eds) Essays in honour of Marvin Zuckerman Elsevier Amsterdam 455–478

    Google Scholar 

  • Z Bhagwagar PJ Cowen GM Goodwin CJ Harmer (2004) ArticleTitleNormalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression Am J Psychiatry 161 166–168 10.1176/appi.ajp.161.1.166 Occurrence Handle14702268 Occurrence Handle10.1176/appi.ajp.161.1.166

    Article  PubMed  Google Scholar 

  • CJ Brown L Carrel HF Willard (1997) ArticleTitleExpression of genes from the human active and inactive X chromosomes Am J Hum Genet 60 1333–1343 Occurrence Handle9199554 Occurrence Handle10.1086/515488 Occurrence Handle1:CAS:528:DyaK2sXktlOqtLk%3D

    Article  PubMed  CAS  Google Scholar 

  • HG Brunner M Nelen XO Breakefield HH Ropers BA van Oost (1993) ArticleTitleAbnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A Science 262 578–580 10.1126/science.8211186 Occurrence Handle8211186 Occurrence Handle10.1126/science.8211186 Occurrence Handle1:CAS:528:DyaK3sXms1yjs7Y%3D

    Article  PubMed  CAS  Google Scholar 

  • L Carrel AA Cottle KC Goglin HF Willard (1999) ArticleTitleA first-generation X-inactivation profile of the human X chromosome Proc Natl Acad Sci USA 96 14440–14444 10.1073/pnas.96.25.14440 Occurrence Handle10588724 Occurrence Handle10.1073/pnas.96.25.14440 Occurrence Handle1:CAS:528:DyaK1MXnvFKksr8%3D

    Article  PubMed  CAS  Google Scholar 

  • L Carrel HF Willard (2005) ArticleTitleX-inactivation profile reveals extensive variability in X-linked gene expression in females Nature 434 400–404 10.1038/nature03479 Occurrence Handle15772666 Occurrence Handle10.1038/nature03479 Occurrence Handle1:CAS:528:DC%2BD2MXit1yqsrY%3D

    Article  PubMed  CAS  Google Scholar 

  • O Cases I Seif J Grimsby P Gaspar K Chen S Pournin U Muller M Aguet C Babinet JC Shih et al. (1995) ArticleTitleAggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAO-A Science 268 1763–1766 10.1126/science.7792602 Occurrence Handle7792602 Occurrence Handle10.1126/science.7792602 Occurrence Handle1:CAS:528:DyaK2MXmsFCitrY%3D

    Article  PubMed  CAS  Google Scholar 

  • A Caspi J McClay TE Moffitt J Mill J Martin IW Craig A Taylor R Poulton (2002) ArticleTitleRole of genotype in the cycle of violence in maltreated children Science 297 851–854 10.1126/science.1072290 Occurrence Handle12161658 Occurrence Handle10.1126/science.1072290 Occurrence Handle1:CAS:528:DC%2BD38XlvV2jsbg%3D

    Article  PubMed  CAS  Google Scholar 

  • IW Craig J Mill GM Craig C Loat LC Schalkwyk (2004) ArticleTitleApplication of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes Eur J Hum Genet 12 639–646 10.1038/sj.ejhg.5201212 Occurrence Handle15114374 Occurrence Handle10.1038/sj.ejhg.5201212 Occurrence Handle1:CAS:528:DC%2BD2cXlvVeiu7o%3D

    Article  PubMed  CAS  Google Scholar 

  • RM Denney A Sharma SK Dave A Waguespack (1994) ArticleTitleA new look at the promoter of the human monoamine oxidase A gene: mapping transcription initiation sites and capacity to drive luciferase expression J Neurochem 63 843–856 Occurrence Handle7519662 Occurrence Handle10.1046/j.1471-4159.1994.63030843.x Occurrence Handle1:CAS:528:DyaK2cXlvFOlsL8%3D

    Article  PubMed  CAS  Google Scholar 

  • P Gaspar O Cases L Maroteaux (2003) ArticleTitleThe developmental role of serotonin: news from mouse molecular genetics Nat Rev Neurosci 4 1002–1012 10.1038/nrn1256 Occurrence Handle14618156 Occurrence Handle10.1038/nrn1256 Occurrence Handle1:CAS:528:DC%2BD3sXovFeit7s%3D

    Article  PubMed  CAS  Google Scholar 

  • J Hallman M Persson B af Klinteberg (2001) ArticleTitleFemale alcoholism: differences between female alcoholics with and without a history of additional substance misuse Alcohol Alcohol 36 564–571 Occurrence Handle11704623 Occurrence Handle10.1093/alcalc/36.6.564 Occurrence Handle1:STN:280:DC%2BD3MnltF2nsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • SG Kornstein (1997) ArticleTitleGender differences in depression: implications for treatment J Clin Psychiatry 58 IssueIDSuppl 15 12–18 Occurrence Handle9427872

    PubMed  Google Scholar 

  • A Meyer-Lindenberg JW Buckholtz BARH Kolachana L Pezawas G Blasi A Wabnitz R Honea B Verchinski JH Callicott et al. (2006) ArticleTitleNeural mechanisms of genetic risk for impulsivity and violence in humans Proc Natl Acad Sci USA 103 6269–6274 10.1073/pnas.0511311103 Occurrence Handle16569698 Occurrence Handle10.1073/pnas.0511311103 Occurrence Handle1:CAS:528:DC%2BD28XktFamsLc%3D

    Article  PubMed  CAS  Google Scholar 

  • DK Nguyen CM Disteche (2006) ArticleTitleDosage compensation of the active X chromosome in mammals Nat Genet 38 47–53 10.1038/ng1705 Occurrence Handle16341221 Occurrence Handle10.1038/ng1705 Occurrence Handle1:CAS:528:DC%2BD2MXhtlCmtrzM

    Article  PubMed  CAS  Google Scholar 

  • CA Olsson GB Byrnes M Lotfi-Miri V Collins R Williamson C Patton RJ Anney (2005) ArticleTitleAssociation between 5-HTTLPR genotypes and persisting patterns of anxiety and alcohol use: results from a 10-year longitudinal study of adolescent mental health Mol Psychiatry 10 868–876 10.1038/sj.mp.4001677 Occurrence Handle15852063 Occurrence Handle10.1038/sj.mp.4001677 Occurrence Handle1:CAS:528:DC%2BD2MXovVOguro%3D

    Article  PubMed  CAS  Google Scholar 

  • NK Popova YA Skrinskaya TG Amstislavskaya GB Vishnivetskaya I Seif E de Meier (2001) ArticleTitleBehavioral characteristics of mice with genetic knockout of monoamine oxidase type A Neurosci Behav Physiol 31 597–602 10.1023/A:1012364910091 Occurrence Handle11766896 Occurrence Handle10.1023/A:1012364910091 Occurrence Handle1:STN:280:DC%2BD38%2FktFeitQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • J Samochowiec A Hajduk A Samochowiec J Horodnicki G Stepien A Grzywacz J Kucharska-Mazur (2004) ArticleTitleAssociation studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum Psychiatry Res 128 21–26 10.1016/j.psychres.2004.05.012 Occurrence Handle15450911 Occurrence Handle10.1016/j.psychres.2004.05.012 Occurrence Handle1:CAS:528:DC%2BD2cXnvV2ku7o%3D

    Article  PubMed  CAS  Google Scholar 

  • I Seif E De Maeyer (1999) ArticleTitleKnockout Corner: knockout mice for monoamine oxidase A Int J Neuropsychopharmcol 2 241–243 10.1017/S1461145799001534 Occurrence Handle10.1017/S1461145799001534

    Article  Google Scholar 

  • B Silverstein (2002) ArticleTitleGender differences in the prevalence of somatic versus pure depression: a replication Am J Psychiatry 159 1051–1052 10.1176/appi.ajp.159.6.1051 Occurrence Handle12042198 Occurrence Handle10.1176/appi.ajp.159.6.1051

    Article  PubMed  Google Scholar 

  • DH Skuse (2000) ArticleTitleImprinting, the X-chromosome, and the male brain: explaining sex differences in the liability to autism Pediatr Res 47 9–16 10.1203/00006450-200001000-00006 Occurrence Handle10625077 Occurrence Handle10.1203/00006450-200001000-00006 Occurrence Handle1:STN:280:DC%2BD3c%2FovVCitw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • KD Tsuchiya JM Greally Y Yi KP Noel JP Truong CM Disteche (2004) ArticleTitleComparative sequence and x-inactivation analyses of a domain of escape in human xp11.2 and the conserved segment in mouse Genome Res 14 1275–1284 10.1101/gr.2575904 Occurrence Handle15197169 Occurrence Handle10.1101/gr.2575904 Occurrence Handle1:CAS:528:DC%2BD2cXlvFWjtrw%3D

    Article  PubMed  CAS  Google Scholar 

  • J Xu R Watkins AP Arnold (2006) ArticleTitleSexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain Gene Expr Patterns 6 146–155 10.1016/j.modgep.2005.06.011 Occurrence Handle16325480 Occurrence Handle10.1016/j.modgep.2005.06.011 Occurrence Handle1:CAS:528:DC%2BD28XhsFaqtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • YW Yu SJ Tsai CJ Hong TJ Chen MC Chen CW Yang (2005) ArticleTitleAssociation study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response Neuropsychopharmacology 30 1719–1723 10.1038/sj.npp.1300785 Occurrence Handle15956990 Occurrence Handle10.1038/sj.npp.1300785 Occurrence Handle1:CAS:528:DC%2BD2MXotFegu70%3D

    Article  PubMed  CAS  Google Scholar 

  • Q Zhu JC Shih (1997) ArticleTitleAn extensive repeat structure down-regulates human monoamine oxidase A promoter activity independent of an initiator-like sequence J Neurochem 69 1368–1373 Occurrence Handle9326264 Occurrence Handle10.1046/j.1471-4159.1997.69041368.x Occurrence Handle1:CAS:528:DyaK2sXmsVCksrc%3D

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neuroscience, Uppsala University, Uppsala, Sweden

    N. Nordquist & L. Oreland

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  1. N. Nordquist
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  2. L. Oreland
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Additional information

This article has been retracted as it represents a duplicate publication of another article.

An erratum to this article is available at http://dx.doi.org/10.1007/s00702-009-0279-9.

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Nordquist, N., Oreland, L. RETRACTED ARTICLE: Monoallelic expression of MAO-A in skin fibroblasts. J Neural Transm 114, 713–716 (2007). https://doi.org/10.1007/s00702-007-0676-x

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  • DOI: https://doi.org/10.1007/s00702-007-0676-x

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