Skip to main content
SpringerLink
Log in

Clozapine/olanzapine-induced recurrence or deterioration of binge eating-related eating disorders

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary

Objective. To explore the association between eating disorders (EDs) prior to the use of clozapine/olanzapine (pre-clozapine/olanzapine EDs) and after initiation of these antipsychotics (post-clozapine/olanzapine EDs).

Method. Sixty-four consecutively admitted patients receiving clozapine/olanzapine were screened using the M-Composite International Diagnostic Interview (M-CIDI) to identify subjects with pre-clozapine/olanzapine EDs (DSM-IV criteria). We investigated post-clozapine/olanzapine EDs and binge eating behavior using the Questionnaire on Eating and Weight Patterns (QEWP) and used the Naranjo probability scale as objective causality assessment.

Results. Post-clozapine/olanzapine EDs were significantly more frequent in patients with pre-clozapine/olanzapine EDs (5 of 6) when compared to patients without pre-clozapine/olanzapine EDs (4 of 58) [χ2 = 26.29; df = 1; p < 0.001] [odds ratio (OR) 67.5; 95% CI: 6.3–25.8]. According to the Naranjo probability scale, recurrence or deterioration of EDs in patients with prior EDs was definitely (n = 1) or probably (n = 4) related to the intake of clozapine/olanzapine.

Conclusion. Clozapine/olanzapine may induce recurrence or deterioration of binge eating symptomatology or full-blown EDs in patients with prior EDs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • DB Allison JL Mentore M Heo LP Chandler JC Cappelleri MC Infante PJ Weiden (1999) ArticleTitleAntipsychotic-induced weight gain: a comprehensive research synthesis Am J Psychiatry 156 1686–1696 Occurrence Handle1:STN:280:DC%2BD3c%2FhvFWmug%3D%3D Occurrence Handle10553730

    CAS  PubMed  Google Scholar 

  • TD Brewerton M Shannon (1992) ArticleTitlePossible clozapine exacerbation of bulimia nervosa Am J Psychiatry 149 1408–1409 Occurrence Handle1:STN:280:DyaK38vhtFemsw%3D%3D Occurrence Handle1530082

    CAS  PubMed  Google Scholar 

  • T Brömel WF Blum A Ziegler E Schulz M Bender C Fleischhaker H Remschmidt JC Krieg J Hebebrand (1998) ArticleTitleSerum leptin levels increase rapidly after initiation of clozapine therapy Mol Psychiatry 3 76–80 10.1038/sj.mp.4000352 Occurrence Handle10.1038/sj.mp.4000352 Occurrence Handle9491817

    Article  PubMed  Google Scholar 

  • JA Costa e Silva N Alvarez G Mazzoti WF Gattaz J Ospina V Larach S Starkstein D Oliva L Cousins M Tohen CC Taylor J Wang PV Tran (2001) ArticleTitleOlanzapine as alternative therapy for patients with haloperidol-induced extrapyramidal symptoms: results of a multicenter, collaborative trial in Latin America J Clin Psychopharmacol 21 375–381 10.1097/00004714-200108000-00004 Occurrence Handle10.1097/00004714-200108000-00004 Occurrence Handle11476121

    Article  PubMed  Google Scholar 

  • DN Crockford G Fisher P Barker (1997) ArticleTitleRisperidone, weight gain, and bulimia nervosa Can J Psychiatry 42 326–327 Occurrence Handle1:STN:280:DyaK2s3ntVSktw%3D%3D Occurrence Handle9114956

    CAS  PubMed  Google Scholar 

  • SM Dursun S Devarajan (2000) ArticleTitleClozapine weight gain, plus topiramate weight loss Can J Psychiatry 45 198 Occurrence Handle1:STN:280:DC%2BD3c3gslartA%3D%3D Occurrence Handle10742883

    CAS  PubMed  Google Scholar 

  • CG Fairburn MJ Cooper (1994) ArticleTitleChanges in selective information processing with three psychological treatments for bulimia nervosa Br J Clin Psychol 33 353–356 Occurrence Handle7994221

    PubMed  Google Scholar 

  • C Foulon (2003) ArticleTitleSchizophrenia and eating disorders Encephale 29 463–466 Occurrence Handle1:STN:280:DC%2BD3srktFyhuw%3D%3D Occurrence Handle14615697

    CAS  PubMed  Google Scholar 

  • R Geist R Davis M Heinman (1998) ArticleTitleBinge/purge symptoms and comorbidity in adolescents with eating disorders Can J Psychiatry 43 507–512 Occurrence Handle1:STN:280:DyaK1czhslCiug%3D%3D Occurrence Handle9653536

    CAS  PubMed  Google Scholar 

  • B Herpertz-Dahlmann B Müller S Herpertz N Heussen J Hebebrand H Remschmidt (2001) ArticleTitleProspective 10-year follow-up in adolescent anorexia nervosa — course, outcome, psychiatric comorbidity, and psychosocial adaptation J Child Psychol Psychiatry 42 603–612 10.1017/S0021963001007326 Occurrence Handle10.1111/1469-7610.00756 Occurrence Handle1:STN:280:DC%2BD38%2Fit1eltQ%3D%3D Occurrence Handle11464965

    Article  CAS  PubMed  Google Scholar 

  • A Joos T Steinert (1997) ArticleTitleComorbidity of schizophrenia and bulimic anorexia. A case with forensic implications [German] Nervenarzt 68 417–420 10.1007/s001150050144 Occurrence Handle10.1007/s001150050144 Occurrence Handle1:STN:280:DyaK2szntVartw%3D%3D Occurrence Handle9280852

    Article  CAS  PubMed  Google Scholar 

  • R Leadbetter M Shutty D Pavalonis V Vieweg P Higgins M Downs (1992) ArticleTitleClozapine-induced weight gain: prevalence and clinical relevance Am J Psychiatry 149 68–72 Occurrence Handle1:STN:280:DyaK38%2FpsFCjtw%3D%3D Occurrence Handle1728188

    CAS  PubMed  Google Scholar 

  • E Levy HC Margolese G Chouinard (2002) ArticleTitleTopiramate produced weight loss following olanzapine-induced weight gain in schizophrenia J Clin Psychiatry 63 1045 Occurrence Handle12469686

    PubMed  Google Scholar 

  • SL McElroy LM Arnold NA Shapira PE Keck SuffixJr NR Rosenthal MR Karim M Kamin JI Hudson (2003) ArticleTitleTopiramate in the treatment of binge eating disorder associated with obesity: a randomized, placebo-controlled trial Am J Psychiatry 160 255–261 10.1176/appi.ajp.160.2.255 Occurrence Handle10.1176/appi.ajp.160.2.255 Occurrence Handle12562571

    Article  PubMed  Google Scholar 

  • C Mehler C Wewetzer U Schulze A Warnke F Theisen RW Dittmann (2001) ArticleTitleOlanzapine in children and adolescents with chronic anorexia nervosa. A study of five cases Eur Child Adolesc Psychiatry 10 151–157 10.1007/s007870170039 Occurrence Handle10.1007/s007870170039 Occurrence Handle1:STN:280:DC%2BD38%2FitlCltw%3D%3D Occurrence Handle11469288

    Article  CAS  PubMed  Google Scholar 

  • MP Mussell JE Mitchell M de Zwaan RD Crosby HC Seim SJ Crow (1996) ArticleTitleClinical characteristics associated with binge eating in obese females: a descriptive study Int J Obes Relat Metab Disord 20 324–331 Occurrence Handle1:STN:280:DyaK283ovFOnsQ%3D%3D Occurrence Handle8680459

    CAS  PubMed  Google Scholar 

  • CA Naranjo U Busto EM Sellers P Sandor I Ruiz EA Roberts E Janecek C Domecq DJ Greenblatt (1981) ArticleTitleA method for estimating the probability of adverse drug reactions Clin Pharmacol Ther 30 239–245 Occurrence Handle1:CAS:528:DyaL3MXltVygsLk%3D Occurrence Handle7249508 Occurrence Handle10.1038/clpt.1981.154

    Article  CAS  PubMed  Google Scholar 

  • F Rosenow S Knake J Hebebrand (2002) ArticleTitleTopiramate and anorexia nervosa Am J Psychiatry 159 2112–2113 10.1176/appi.ajp.159.12.2112-a Occurrence Handle10.1176/appi.ajp.159.12.2112-a Occurrence Handle12450969

    Article  PubMed  Google Scholar 

  • JH Rosenvinge M Martinussen E Ostensen (2000) ArticleTitleThe comorbidity of eating disorders and personality disorders: a metaanalytic review of studies published between 1983 and 1998 Eat Weight Disord 5 52–61 Occurrence Handle1:STN:280:DC%2BD3M%2FntlOnsw%3D%3D Occurrence Handle10941603

    CAS  PubMed  Google Scholar 

  • M Schüler-Springorum J Hebebrand PM Wehmeier H Remschmidt (2002) ArticleTitleIs topiramate effective for weight loss in neuroleptic-induced obesity? 2 case reports [German] Z Kinder Jugendpsychiatr Psychother 30 51–58 10.1024//1422-4917.30.1.51 Occurrence Handle10.1024//1422-4917.30.1.51 Occurrence Handle11876083

    Article  PubMed  Google Scholar 

  • NA Shapira TD Goldsmith SL McElroy (2000) ArticleTitleTreatment of binge-eating disorder with topiramate: a clinical case series J Clin Psychiatry 61 368–372 Occurrence Handle1:CAS:528:DC%2BD3cXktFGhtr0%3D Occurrence Handle10847312 Occurrence Handle10.4088/JCP.v61n0508

    Article  CAS  PubMed  Google Scholar 

  • RL Spitzer S Yanovski T Wadden R Wing MD Marcus A Stunkard M Devlin J Mitchell D Hasin RL Horne (1993) ArticleTitleBinge eating disorder: its further validation in a multisite study Int J Eat Disord 13 137–153 10.1002/1098-108X(199303)13:2<161::AID-EAT2260130204>3.0.CO;2-R Occurrence Handle10.1002/1098-108X(199303)13:2<161::AID-EAT2260130204>3.0.CO;2-R Occurrence Handle1:STN:280:DyaK3s3jsl2itg%3D%3D Occurrence Handle8477283

    Article  CAS  PubMed  Google Scholar 

  • RH Striegel-Moore V Garvin FA Dohm RA Rosenheck (1999) ArticleTitlePsychiatric comorbidity of eating disorders in men: a national study of hospitalized veterans Int J Eat Disord 25 399–404 10.1002/(SICI)1098-108X(199905)25:4<399::AID-EAT4>3.0.CO;2-0 Occurrence Handle10.1002/(SICI)1098-108X(199905)25:4<399::AID-EAT4>3.0.CO;2-0 Occurrence Handle1:STN:280:DyaK1M3hvV2ktw%3D%3D Occurrence Handle10202650

    Article  CAS  PubMed  Google Scholar 

  • FM Theisen S Cichon A Linden M Martin H Remschmidt J Hebebrand (2001) ArticleTitleClozapine and weight gain Am J Psychiatry 158 816 10.1176/appi.ajp.158.5.816 Occurrence Handle10.1176/appi.ajp.158.5.816 Occurrence Handle1:STN:280:DC%2BD3M3ovVGltg%3D%3D Occurrence Handle11329412

    Article  CAS  PubMed  Google Scholar 

  • FM Theisen A Linden IR König M Martin H Remschmidt J Hebebrand (2003) ArticleTitleSpectrum of binge eating symptomatology in patients treated with clozapine and olanzapine J Neural Transm 110 111–121 Occurrence Handle1:CAS:528:DC%2BD3sXltlCitw%3D%3D Occurrence Handle12541016

    CAS  PubMed  Google Scholar 

  • HU Wittchen G Lachner U Wunderlich H Pfister (1998a) ArticleTitleTest-retest reliability of the computerized DSM-IV version of the Munich-Composite International Diagnostic Interview (M-CIDI) Soc Psychiatry Psychiatr Epidemiol 33 568–578 10.1007/s001270050095 Occurrence Handle10.1007/s001270050095 Occurrence Handle1:STN:280:DyaK1M%2FitVKltA%3D%3D

    Article  CAS  Google Scholar 

  • HU Wittchen CB Nelson G Lachner (1998b) ArticleTitlePrevalence of mental disorders and psychosocial impairments in adolescents and young adults Psychol Med 28 109–112 10.1017/S0033291797005928 Occurrence Handle10.1017/S0033291797005928 Occurrence Handle1:STN:280:DyaK1c7ksVKrsw%3D%3D

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany

    S. Gebhardt, M. Haberhausen, H. Remschmidt, M. Heinzel-Gutenbrunner & F. M. Theisen

  2. Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany

    S. Gebhardt & J.-C. Krieg

  3. Institute of Medical Biometry and Epidemiology, University of Marburg, Marburg, Germany

    M. Heinzel-Gutenbrunner

  4. Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Duisburg, Germany

    J. Hebebrand

Authors
  1. S. Gebhardt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Haberhausen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J.-C. Krieg
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Remschmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Heinzel-Gutenbrunner
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. Hebebrand
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. F. M. Theisen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gebhardt, S., Haberhausen, M., Krieg, JC. et al. Clozapine/olanzapine-induced recurrence or deterioration of binge eating-related eating disorders. J Neural Transm 114, 1091–1095 (2007). https://doi.org/10.1007/s00702-007-0663-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00702-007-0663-2

Search

Navigation