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The involvement of cerebellar dopamine D3 receptors in locomotor activity of rats

  • Basic Neurosciences, Genetics and Immunology - Short Communication
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Abstract

A preferential agonist of dopamine D3 receptors, 7-hydroxy-N-N-di-n-propyl-2-aminotetralin (7-OH-DPAT), injected into the cerebellar lobules 9 and 10 (0.001–10 μg/0.5 μl) dose-dependently reduced locomotor activity of rats. 7-OH-DPAT injections into the lobule 8 were ineffective. The 7-OH-DPAT-induced hypolocomotion was inhibited by intracerebellar (0.9 μg/0.5 μl) or systemic (0.2 mg/kg sc) injection of a selective D3 receptor antagonist, (3aR,9bS)-N-[4-(8-cyano-1,3a,4,9b-tetrahydro-3H-benzopyrano[3,4-c]pyrrole-2-yl)-butyl]-(4-phenyl) benzamide (S33084). The present results indicate that dopamine D3 receptors in lobules 9 and 10 contribute to 7-OH-DPAT-induced hypolocomotion.

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Acknowledgments

This study was supported by the statutory funds of the Institute of Pharmacology. The authors are very grateful to Dr. Mark J. Millan (Institut de Recherches Sevier Centre de Recherches de Croissy) for a generous gift of S33084.

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Authors and Affiliations

  1. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., 31-343, Kraków, Poland

    W. Kolasiewicz & K. Ossowska

  2. Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., 31-343, Kraków, Poland

    J. Maj

Authors
  1. W. Kolasiewicz
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  2. J. Maj
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  3. K. Ossowska
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Correspondence to K. Ossowska.

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J. Maj is now deceased.

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Kolasiewicz, W., Maj, J. & Ossowska, K. The involvement of cerebellar dopamine D3 receptors in locomotor activity of rats. J Neural Transm 115, 677–681 (2008). https://doi.org/10.1007/s00702-007-0009-0

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  • DOI: https://doi.org/10.1007/s00702-007-0009-0

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