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Weight gain associated with clozapine, olanzapine and risperidone in children and adolescents

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Summary.

The study was aimed at the evaluation of weight gain associated with atypical antipsychotics and its clinical risk factors in children and adolescents. Weight and body mass index (BMI) of initially hospitalised patients treated with clozapine (n = 15), olanzapine (n = 15), and risperidone (n = 15) were prospectively monitored on a weekly basis for the first 6 weeks. Different clinical risk factors were tested for their association with weight gain in the three groups. All three groups experienced significant weight gain between baseline and endpoint (p < 0.0001). For all weight measures, planned comparisons were all significant between olanzapine vs. clozapine and risperidone, respectively. Average weight gain was significantly higher for the olanzapine group (mean = 4.6 kg, SD = 1.9) than for the risperidone (mean = 2.8 kg, SD = 1.3) and clozapine (mean = 2.5 kg, SD = 2.9) groups. Olanzapine and risperidone, but not clozapine, caused a disproportionately higher weight gain in children and adolescents in comparison to adults.

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Authors and Affiliations

  1. Department of Child and Adolescent Psychiatry and Psychotherapy, Albert Ludwig University, Freiburg, Germany

    C. Fleischhaker, K. Hennighausen, R. Rauh & E. Schulz

  2. Clinic and Polyclinic for Psychiatry and Psychotherapy for Child and Adolescent Age Groups, Philipp University, Marburg, Germany

    P. Heiser & H. Remschmidt

  3. Clinic for Child and Adolescent Psychiatry, University Clinic, RWTH Aachen, Aachen, Germany

    B. Herpertz-Dahlmann & K. Holtkamp

  4. Clinic and Polyclinic for Child and Adolescent Psychiatry, Julius Maximilian University, Wuerzburg, Germany

    C. Mehler-Wex & A. Warnke

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  1. C. Fleischhaker
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  2. P. Heiser
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  3. K. Hennighausen
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  4. B. Herpertz-Dahlmann
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Fleischhaker, C., Heiser, P., Hennighausen, K. et al. Weight gain associated with clozapine, olanzapine and risperidone in children and adolescents. J Neural Transm 114, 273–280 (2007). https://doi.org/10.1007/s00702-006-0602-7

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