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CSF cholecystokinin, γ-aminobutyric acid and neuropeptide Y in pathological gamblers and healthy controls

Journal of Neural Transmission volume 114, pages 499–503 (2007)Cite this article

An Erratum to this article was published on 01 May 2007

Summary

The sulphated cholecystokinin (CCK) octapeptide (CCK-8S), the CCK tetrapeptide (CCK-4), neuropeptide Y (NPY) and γ-aminobutyric acid (GABA) were determined in cerebrospinal fluid (CSF) obtained from 11 pathological male gamblers and 11 healthy male controls. Compared with healthy controls, pathological male gamblers displayed higher concentrations of CCK-8S, CCK-4 and GABA (but not NPY). A gradient with decreasing concentrations from the first to the third 6-ml CSF fraction was found for CCK-8S, CCK-4 and NPY, but only in pathological gamblers. Disrupted gradients were found for GABA and for NPY in healthy controls.

Given that CCK is a modulator of dopamine in the reward process, the increase in CCK-8S and CCK-4 is not unexpected. The high level of GABA in pathological gamblers is in conformity with a compensatory inhibitory action on noradrenergic neurons. The CSF gradient of CCK-8S and CCK-4 in pathological male gamblers (but not healthy controls) might indicate a difference in diurnal variation. The results obtained are in line with an altered CCK and GABA function in pathological gambling.

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Affiliations

  1. Department of Neuroscience and Locomotion, Psychiatry Section, Faculty of Health Sciences, Linköping University, Linköping, Sweden

    C. Nordin & I. Sjödin

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  1. C. Nordin
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  2. I. Sjödin
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An erratum to this article is available at http://dx.doi.org/10.1007/s00702-007-0736-2.

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Nordin, C., Sjödin, I. CSF cholecystokinin, γ-aminobutyric acid and neuropeptide Y in pathological gamblers and healthy controls. J Neural Transm 114, 499–503 (2007). https://doi.org/10.1007/s00702-006-0593-4

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  • DOI: https://doi.org/10.1007/s00702-006-0593-4

  • Keywords: Pathological gambling, CSF, cholecystokinin, NPY, GABA